Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Diana Schenkwein"'
Autor:
Farhana Jahan, Jan Koski, Diana Schenkwein, Seppo Ylä-Herttuala, Helka Göös, Sini Huuskonen, Markku Varjosalo, Pilvi Maliniemi, Judith Leitner, Peter Steinberger, Hans-Jörg Bühring, Kim Vettenranta, Matti Korhonen
Publikováno v:
Frontiers in Molecular Medicine, Vol 3 (2023)
Background: T cells that are genetically modified with chimeric antigen receptor (CAR) hold promise for immunotherapy of cancer. Currently, there are intense efforts to improve the safety and efficacy of CAR T cell therapies against liquid and solid
Externí odkaz:
https://doaj.org/article/99b6cf95a3c24eb697aeaeaaf665b268
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0280894 (2023)
Targeting transgene integration into a safe genomic locus would be very important for gene therapy. We have generated lentivirus vectors containing the ribosomal RNA-recognising I-PpoI endonuclease fused to viral integrase, and transgene cassettes wi
Externí odkaz:
https://doaj.org/article/e36aaf9d6aab417dafc5f7ea4d070bf3
Autor:
Jan Koski, Farhana Jahan, Annu Luostarinen, Diana Schenkwein, Seppo Ylä-Herttuala, Helka Göös, Hector Monzo, Päivi M. Ojala, Pilvi Maliniemi, Matti Korhonen
Publikováno v:
Frontiers in Molecular Medicine, Vol 2 (2022)
Background: T cells equipped with chimeric antigen receptors (CAR) have shown remarkable efficacy in targeting B lineage malignancies. Improvement of the CAR structure is needed, however, with a view to developing flexibly modifiable spacers that are
Externí odkaz:
https://doaj.org/article/3970041dcbc24907a9291c98de9f005e
Publikováno v:
Molecular Therapy
Publikováno v:
Mol Ther
Lentivirus vectors (LVs) are efficient tools for gene transfer, but the non-specific nature of transgene integration by the viral integration machinery carries an inherent risk for genotoxicity. We modified the integration machinery of LVs and harnes
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1448
The method in this chapter describes the design of human immunodeficiency virus type 1 (HIV-1) integrase (IN)-fusion proteins which we have developed to transport different proteins into the nuclei of lentiviral vector (LV)-transduced cells. The IN-f
Autor:
Diana Schenkwein, Seppo Ylä-Herttuala
Publikováno v:
Lentiviral Vectors and Exosomes as Gene and Protein Delivery Tools ISBN: 9781493937516
The method in this chapter describes the design of human immunodeficiency virus type 1 (HIV-1) integrase (IN)-fusion proteins which we have developed to transport different proteins into the nuclei of lentiviral vector (LV)-transduced cells. The IN-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::537c6cb909fe5182396e393bf371ef25
https://doi.org/10.1007/978-1-4939-3753-0_14
https://doi.org/10.1007/978-1-4939-3753-0_14
Publikováno v:
Human Gene Therapy. 21:589-602
Lentiviral vectors have broad target cell tropism and efficient machinery to integrate transgenes into the host genome. Modification of these vectors by incorporating heterologous proteins into virions has relied mostly on the fusion of proteins into
Autor:
Diana Schenkwein, Riikka Kivelä, Eija Pirinen, Jenni Huusko, Seppo Ylä-Herttuala, Marike H. Dijkstra, Kari Alitalo
Publikováno v:
Scientific Reports
Vascular endothelial growth factor-B (VEGF-B) has been implicated to play a significant role in coronary vessel growth and endothelial uptake and transport of fatty acids in heart and skeletal muscle. Additionally, recent studies have shown that Vegf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b9ab1cae5efb658c30a57c2e70be76
http://hdl.handle.net/10138/162554
http://hdl.handle.net/10138/162554