Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Diana Rafael"'
Autor:
Mar Gil, Lareen Khouri, Imma Raurell, Diana Rafael, Fernanda Andrade, Ibane Abasolo, Simo Schwartz, María Martínez-Gómez, María Teresa Salcedo, Juan Manuel Pericàs, Diana Hide, Mingxing Wei, Norman Metanis, Joan Genescà, María Martell
Publikováno v:
Pharmaceutics, Vol 15, Iss 10, p 2463 (2023)
In this study, we developed functionalized polymeric micelles (FPMs) loaded with simvastatin (FPM-Sim) as a drug delivery system to target liver sinusoidal endothelial cells (LSECs) for preserving liver function in chronic liver disease (CLD). Polyme
Externí odkaz:
https://doaj.org/article/e603b3eed6d04f5284bf5147d9e90211
Autor:
Fernanda Andrade, Júlia German-Cortés, Sara Montero, Pilar Carcavilla, Diego Baranda-Martínez-Abascal, Marc Moltó-Abad, Joaquín Seras-Franzoso, Zamira Vanessa Díaz-Riascos, Diana Rafael, Ibane Abasolo
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1686 (2023)
Kirsten rat sarcoma (KRAS) is a small GTPase which acts as a molecular switch to regulate several cell biological processes including cell survival, proliferation, and differentiation. Alterations in KRAS have been found in 25% of all human cancers,
Externí odkaz:
https://doaj.org/article/dd8ca0bab8c34b6b8981820db0488c52
Autor:
Diana Rafael, Marcelo Guerrero, Adolfo Marican, Diego Arango, Bruno Sarmento, Roser Ferrer, Esteban F. Durán-Lara, Simon J. Clark, Simo Schwartz
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1484 (2023)
Slow-release delivery systems are needed to ensure long-term sustained treatments for retinal diseases such as age-related macular degeneration and diabetic retinopathy, which are currently treated with anti-angiogenic agents that require frequent in
Externí odkaz:
https://doaj.org/article/54122d48dbdd4939bc52a5a5f7edf6e0
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 831 (2023)
Despite all the advances seen in recent years, the severe adverse effects and low specificity of conventional chemotherapy are still challenging problems regarding cancer treatment. Nanotechnology has helped to address these questions, making importa
Externí odkaz:
https://doaj.org/article/d1d3e3162cf847afb59f712497d5d60c
Autor:
Alfredo Pereira, Elizabeth Valdés-Muñoz, Adolfo Marican, Gustavo Cabrera-Barjas, Sekar Vijayakumar, Oscar Valdés, Diana Rafael, Fernanda Andrade, Paulina Abaca, Daniel Bustos, Esteban F. Durán-Lara
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 474 (2023)
In light of the growing bacterial resistance to antibiotics and in the absence of the development of new antimicrobial agents, numerous antimicrobial delivery systems over the past decades have been developed with the aim to provide new alternatives
Externí odkaz:
https://doaj.org/article/b0034121d5a04576982295b37001e6da
Autor:
Diana Rafael, Petra Gener, Fernanda Andrade, Joaquin Seras-Franzoso, Sara Montero, Yolanda Fernández, Manuel Hidalgo, Diego Arango, Joan Sayós, Helena F. Florindo, Ibane Abasolo, Simó Schwartz, Mafalda Videira
Publikováno v:
Drug Delivery, Vol 25, Iss 1, Pp 961-972 (2018)
Development of RNA interference-based therapies with appropriate therapeutic window remains a challenge for advanced cancers. Because cancer stem cells (CSC) are responsible of sustaining the metastatic spread of the disease to distal organs and the
Externí odkaz:
https://doaj.org/article/063d196c54e043fe992d7e4cc0565e88
Autor:
Fernanda Andrade, Maria Mercé Roca-Melendres, Esteban F. Durán-Lara, Diana Rafael, Simó Schwartz
Publikováno v:
Cancers, Vol 13, Iss 5, p 1164 (2021)
Cancer remains as the second leading cause of death, worldwide. Despite the enormous important advances observed in the last decades, advanced stages of the disease remain incurable. The severe side effects associated to systemic high doses of chemot
Externí odkaz:
https://doaj.org/article/5a417fa91e9b4c47bb48d95ca4a9126c
Autor:
Laia Hernandez-Oller, Joaquin Seras-Franzoso, Fernanda Andrade, Diana Rafael, Ibane Abasolo, Petra Gener, Simo Schwartz Jr.
Publikováno v:
Pharmaceutics, Vol 12, Iss 12, p 1146 (2020)
Within tumors, Cancer Stem Cell (CSC) subpopulation has an important role in maintaining growth and dissemination while preserving high resistance against current treatments. It has been shown that, when CSCs are eliminated, the surrounding Different
Externí odkaz:
https://doaj.org/article/0339bf81df4d4515934fb1ae89483aff
Autor:
Laia Gifre-Renom, Joaquin Seras-Franzoso, Diana Rafael, Fernanda Andrade, Olivia Cano-Garrido, Francesc Martinez-Trucharte, Estefania Ugarte-Berzal, Erik Martens, Lise Boon, Antonio Villaverde, Ghislain Opdenakker, Simó Schwartz, Anna Arís, Elena Garcia-Fruitós
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 157 (2020)
Inclusion bodies (IBs) are protein nanoclusters obtained during recombinant protein production processes, and several studies have demonstrated their potential as biomaterials for therapeutic protein delivery. Nevertheless, IBs have been, so far, exc
Externí odkaz:
https://doaj.org/article/24defb96d43a4bfa8cbcff300c34d9ed
Autor:
Sara Montero, Joaquin Seras-Franzoso, Fernanda Andrade, Francesc Martinez-Trucharte, Mireia Vilar-Hernández, Manuel Quesada, Helena Xandri, Diego Arango, Ibane Abasolo, Diana Rafael, Simo Schwartz
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 185 (2020)
Structural maintenance of chromosomes protein 2 (SMC2) is a central component of the condensin complex involved in DNA supercoiling, an essential process for embryonic stem cell survival. SMC2 over-expression has been related with tumorigenesis and c
Externí odkaz:
https://doaj.org/article/b622e52b18ce44d4ba9955ecd7298334