Výsledky vyhledávání - "Diana Quinonez"

Akademický článek

Comparative histopathological analysis of age‐associated intervertebral disc degeneration in CD‐1 and C57BL/6 mice: Anatomical and sex‐based differences

Autor: Jeffrey L. Hutchinson, Matthew A. Veras, Meghan E. Serjeant, Matthew R. McCann, Ashley L. Kelly, Diana Quinonez, Frank Beier, Cheryle A. Séguin

Publikováno v: JOR Spine, Vol 6, Iss 4, Pp n/a-n/a (2023)

Abstract Background Intervertebral disc (IVD) degeneration is a major contributor to back pain and disability. The cause of IVD degeneration is multifactorial, with no disease‐modifying treatments. Mouse models are commonly used to study IVD degene

Externí odkaz: https://doaj.org/article/3349046b68c24b59ae972a07348cb7a3

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Akademický článek

Glycerol induced paraspinal muscle degeneration leads to hyper-kyphotic spinal deformity in wild-type mice

Autor: Alex M. Noonan, Emily Buliung, K. Josh Briar, Diana Quinonez, Cheryle A. Séguin, Stephen H. M. Brown

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract Degenerative spinal disorders, including kyphotic deformity, are associated with a range of degenerative characteristics of the paraspinal musculature. It has therefore been hypothesized that paraspinal muscular dysfunction is a causative fa

Externí odkaz: https://doaj.org/article/357201b5751a4d58a1c647c671be8dd6

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Akademický článek

Stiffness and axial pain are associated with the progression of calcification in a mouse model of diffuse idiopathic skeletal hyperostosis

Autor: Dale E. Fournier, Matthew A. Veras, Courtney R. Brooks, Diana Quinonez, Magali Millecamps, Laura S. Stone, Cheryle A. Séguin

Publikováno v: Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-14 (2023)

Abstract Background Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by progressive calcification of spinal tissues; however, the impact of calcification on pain and function is poorly understood. This study examined the association b

Externí odkaz: https://doaj.org/article/cd320cdadedb4674991a74c50029c2df

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The Role of Panx3 in Age-Associated and Injury-Induced Intervertebral Disc Degeneration

Autor: Frank Beier, Diana Quinonez, Paxton M. Moon, Meaghan E. Serjeant, Cheryle A. Séguin, Silvia Penuela

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 3
Physiology and Pharmacology Publications
International Journal of Molecular Sciences, Vol 22, Iss 1080, p 1080 (2021)

Pannexin 3 (Panx3) is a mechanosensitive, channel-forming glycoprotein implicated in the progression of post-traumatic osteoarthritis. Despite evidence for Panx3 expression in the intervertebral disc (IVD), its function in this cartilaginous joint st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776640edc5c9e744db25648f87f45ffb
http://europepmc.org/articles/PMC7865929

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Disruption of biomineralization pathways in spinal tissues of a mouse model of diffuse idiopathic skeletal hyperostosis

Autor: Sumeeta Warraich, Cheryle A. Séguin, James R. Hammond, S. Jeffrey Dixon, Neil A. Tenn, Diana Quinonez, Hisataka, David W. Holdsworth

Publikováno v: Bone and Joint Institute

Equilibrative nucleoside transporter 1 (ENT1) mediates passage of adenosine across the plasma membrane. We reported previously that mice lacking ENT1 (ENT1(-/-)) exhibit progressive ectopic mineralization of spinal tissues resembling diffuse idiopath

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d04a2700b525c84f19f984f742b203
https://ir.lib.uwo.ca/boneandjointpub/1184

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Targeting the annulus fibrosus of the intervertebral disc: Col1a2-Cre(ER)T mice show specific activity of Cre recombinase in the outer annulus fibrosus

Autor: Cheryle A. Séguin, Diana Quinonez, Andrew Leask, Katherine Quesnel, Jake Bedore

Publikováno v: Bone and Joint Institute

© 2016, The International CCN Society. Degeneration of the intervertebral disc (IVD) is a major underlying contributor to back pain—the single leading cause of disability worldwide. However, we possess a limited understanding of the etiology under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b393428fbf2c0207f0a2af01282ae53
https://europepmc.org/articles/PMC4882308/

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Hypoxanthine uptake by skeletal muscle microvascular endothelial cells from equilibrative nucleoside transporter 1 (ENT1)-null mice: effect of oxidative stress

Autor: Diana Quinonez, Derek B.J. Bone, James R. Hammond, M. Antic

Publikováno v: Microvascular research. 98

Adenosine is an endogenous regulator of vascular tone. This activity of adenosine is terminated by its uptake and metabolism by microvascular endothelial cells (MVEC). The predominant transporter involved is ENT1 (equilibrative nucleoside transporter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c25429c70047de769fcf9e59c6926a
https://pubmed.ncbi.nlm.nih.gov/25448155

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Loss of equilibrative nucleoside transporter 1 in mice leads to progressive ectopic mineralization of spinal tissues resembling diffuse idiopathic skeletal hyperostosis in humans

Autor: James R. Hammond, Maria Drangova, Derek B.J. Bone, Diana Quinonez, Hisataka, David W. Holdsworth, Sumeeta Warraich, Cheryle A. Séguin, S. Jeffrey Dixon, Doo Sup Choi

Publikováno v: Paediatrics Publications

Diffuse idiopathic skeletal hyperostosis (DISH) is a noninflammatory spondyloarthropathy, characterized by ectopic calcification of spinal tissues. Symptoms include spine pain and stiffness, and in severe cases dysphagia and spinal cord compression.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9774c14bafb1ae1741c6317dd2072389
https://pubmed.ncbi.nlm.nih.gov/23184610

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