Výsledky vyhledávání - "Diana P. Saraiva"

Akademický článek

Establishment of a 3D Co-culture With MDA-MB-231 Breast Cancer Cell Line and Patient-Derived Immune Cells for Application in the Development of Immunotherapies

Autor: Diana P. Saraiva, Ana T. Matias, Sofia Braga, António Jacinto, M. Guadalupe Cabral

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

3D cell culture including different cell types, such as immune cells, is a representative platform that mimics the tumor microenvironment. Here we disclose an easy-to-handle 3D co-culture protocol using a scaffold-free technique with the breast cance

Externí odkaz: https://doaj.org/article/bc441934f0374dd7b0117b254b9698ea

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Akademický článek

HLA-DR in Cytotoxic T Lymphocytes Predicts Breast Cancer Patients' Response to Neoadjuvant Chemotherapy

Autor: Diana P. Saraiva, António Jacinto, Paula Borralho, Sofia Braga, M. Guadalupe Cabral

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Prediction of breast cancer response to Neoadjuvant Chemotherapy (NACT) is an urgent need to promptly direct non-responder patients to alternative therapies. Infiltrating T lymphocytes, namely cytotoxic T lymphocytes (CTLs) have been appointed as pre

Externí odkaz: https://doaj.org/article/c0c486f36ecf420997423f64f05bad58

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Cholesteryl hemiazelate Identified in Cardiovascular Disease Patients Causesin vitroandin vivoInflammation

Oxidation of polyunsaturated fatty acids (PUFA) in low-density lipoproteins (LDL) trapped in the arterial intima plays a critical role in atherosclerosis. Though there have been many studies on the atherogenicity of oxidized derivatives of unsaturate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fed33e6e31e3b082f7491a1e04b301c5
https://doi.org/10.1101/2023.02.09.527823

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Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses

Autor: Rute Salvador, M. Guadalupe Cabral, Sofia Braga, Diana P. Saraiva, António Jacinto, Nídia de Sousa, Bruna Correia

Publikováno v: Oncotarget

Neutrophils are prominent immune components of solid tumors, which can protect against the onset of cancer (N1) or have pro-tumor activity (N2). Circulating neutrophils, divided into high density neutrophils (HDN) and low density neutrophils (LDN), f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a788254b6b8a0ec01724bfc1aae5aef4
http://europepmc.org/articles/PMC8629401

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Expression of HLA-DR in Cytotoxic T Lymphocytes: A Validated Predictive Biomarker and a Potential Therapeutic Strategy in Breast Cancer

Autor: Sofia Braga, Ana Antunes, Zita Seabra, Paula Borralho, Beatriz Assis, Ida Negreiros, António Jacinto, Rute Salvador, M. Guadalupe Cabral, Isabel L. Pereira, Diana P. Saraiva, Sofia Azeredo-Lopes

Publikováno v: Cancers
Cancers, Vol 13, Iss 3841, p 3841 (2021)
Volume 13
Issue 15
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Simple Summary More than 50% of breast cancer (BC) patients selected for neoadjuvant chemotherapy (NACT) are subjected to at least a 6-month regimen of this treatment without a clear benefit, probably delaying more effective therapeutic strategies an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185ac4cd8b895a0493ecb4e9b358d227
https://pubmed.ncbi.nlm.nih.gov/34359741

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Determination of HLA-DR level in cytotoxic T lymphocytes: a new validated tool to predict breast cancer response to treatment

Autor: Sofia Azeredo-Lopes, Pereira I, António Jacinto, Sofia Braga, Ana Antunes, Seabra Z, Negreiros I, Assis B, Diana P. Saraiva, Rute Salvador, Paula Borralho, Cabral Mg

BackgroundNeoadjuvant chemotherapy (NACT) is the usual treatment for locally-advanced breast cancer (BC). However, more than half of the patients lack an effective response to this treatment. Thus, it’s urgent to find predictive biomarkers. Recentl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::548d536a4f2588b6c960a7a644ba10fe
https://doi.org/10.1101/2021.04.29.441985

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Population genetics-informed meta-analysis in seven genes associated with risk to dengue fever disease

Autor: Anavaj Sakuntabhai, Luísa Pereira, Verónica Fernandes, María G. Guzmán, Beatriz Sierra, Isabelle Casademont, Nourdin Harich, Bruno Cavadas, Marisa Oliveira, Lotfi Cherni, Nicole Pedro, Farida Alshamali, Fanny Koeth, Diana P. Saraiva

Publikováno v: Infection, Genetics and Evolution
Infection, Genetics and Evolution, Elsevier, 2018, 62, pp.60-72. ⟨10.1016/j.meegid.2018.04.018⟩
Infection, Genetics and Evolution, 2018, 62, pp.60-72. ⟨10.1016/j.meegid.2018.04.018⟩

International audience; Population genetics theory predicted that rare frequent markers would be the main contributors for heritability of complex diseases, but meta-analyses of genome-wide association studies are revealing otherwise common markers,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afac280a4a0c8213dcf883b7fcb205fe
https://hal.archives-ouvertes.fr/hal-01873838

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A 3D co-culture platform of breast cancer and patient derived immune cells to analyse the response to chemotherapy and immunotherapies

Autor: Sofia Braga, M.G. Cabral, Diana P. Saraiva, António Jacinto

Publikováno v: Annals of Oncology. 30:v781

Background Neoadjuvant chemotherapy (NACT) is the treatment option for locally advanced breast cancer (BC). However, more than half of the patients have no response. Thus, there is an urgent need to find biomarkers of NACT response and personalized t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6aea7eddfdd2f5677867cd998301b657
https://doi.org/10.1093/annonc/mdz268.064

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