Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Diana P Raymundo"'
Autor:
Raphael Pineau, Pierre Jean Le Reste, Tony Avril, Ulrich Jarry, Eric Chevet, Diana Pelizzari-Raymundo
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103304- (2024)
Summary: In cancer research, murine models play a crucial role as highly valuable preclinical tools. Here, we present a protocol to generate a murine model of glioblastoma through the direct intracranial injection of tumor cells. We describe steps fo
Externí odkaz:
https://doaj.org/article/d6c8208a6d204dbaa5b17d57b18891d6
Autor:
Katia M S Cabral, Diana P Raymundo, Viviane S Silva, Laura A G Sampaio, Laizes Johanson, Luis Fernando Hill, Fabio C L Almeida, Yraima Cordeiro, Marcius S Almeida
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137916 (2015)
BEX3 (Brain Expressed X-linked protein 3) is a member of a mammal-specific placental protein family. Several studies have found the BEX proteins to be associated with neurodegeneration, the cell cycle and cancer. BEX3 has been predicted to be intrins
Externí odkaz:
https://doaj.org/article/3507b2c2b1c34885a8529e50555fd150
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136761 (2015)
Pyridoxinamine 5'-phosphate oxidases (P(N/M)P oxidases) that bind flavin mononucleotide (FMN) and oxidize pyridoxine 5'-phosphate or pyridoxamine 5'-phosphate to form pyridoxal 5'-phosphate (PLP) are an important class of enzymes that play a central
Externí odkaz:
https://doaj.org/article/c45f960b4ca6442cb9b735918ebac440
Autor:
S. Jalil Mahdizadeh, Johan Grandén, Diana Pelizzari-Raymundo, Xavier Guillory, Antonio Carlesso, Eric Chevet, Leif A. Eriksson
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract The flavonoid Quercetin (Qe) was identified as an activator of Inositol-requiring enzyme 1 (IRE1) in S. cerevisiae (scIre1p), but its impact on human IRE1 (hIRE1) remains controversial due to the absence of a conserved Qe binding site. We ha
Externí odkaz:
https://doaj.org/article/987ce2cf50b941f4876954d45013c533
Autor:
Diana Pelizzari-Raymundo, Dimitrios Doultsinos, Raphael Pineau, Chloé Sauzay, Thodoris Koutsandreas, Timothy Langlais, Antonio Carlesso, Elena Gkotsi, Luc Negroni, Tony Avril, Aristotelis Chatziioannou, Eric Chevet, Leif A. Eriksson, Xavier Guillory
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106687- (2023)
Summary: Inositol-requiring enzyme 1 (IRE1) is a major mediator of the unfolded protein response (UPR), which is activated upon endoplasmic reticulum (ER) stress. Tumor cells experience ER stress due to adverse microenvironmental cues, a stress overc
Externí odkaz:
https://doaj.org/article/ec4db961d77f43c39ac1a07754c5bca7
Sensor dimer disruption as a new mode of action to block the IRE1-mediated unfolded protein response
Autor:
Kosala N. Amarasinghe, Diana Pelizzari-Raymundo, Antonio Carlesso, Eric Chevet, Leif A. Eriksson, Sayyed Jalil Mahdizadeh
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1584-1592 (2022)
The unfolded protein response (UPR) is activated to cope with an accumulation of improperly folded proteins in the Endoplasmic reticulum (ER). The Inositol requiring enzyme 1α (IRE1α) is the most evolutionary conserved transducer of the UPR. Activa
Externí odkaz:
https://doaj.org/article/9c0a764ffe7b4efaad7c3bc6b85214d1
Autor:
Guilherme A. P. de Oliveira, Diana P. Raymundo, Torsten Herrmann, Laizes Johanson, Luciana Romão, Fernando L. Palhano, Júlia Araújo de Freitas, Marcius S. Almeida, Cristiane Latge, Katia M. S. Cabral, Debora Foguel
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (33), pp.20527-20540. ⟨10.1074/jbc.M115.662254⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (33), pp.20527-20540. ⟨10.1074/jbc.M115.662254⟩
International audience; Cerebral dopamine neurotrophic factor (CDNF) is a promising therapeutic agent for Parkinson disease. As such, there has been great interest in studying its mode of action, which remains unknown. The three-dimensional crystal s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e5fd86abac67f62d8586d4365e585f
https://hal.archives-ouvertes.fr/hal-01187615
https://hal.archives-ouvertes.fr/hal-01187615
Publikováno v:
The FASEB Journal. 28
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 9, p e0136761 (2015)
PLoS ONE, Vol 10, Iss 9, p e0136761 (2015)
Pyridoxinamine 5'-phosphate oxidases (P(N/M)P oxidases) that bind flavin mononucleotide (FMN) and oxidize pyridoxine 5'-phosphate or pyridoxamine 5'-phosphate to form pyridoxal 5'-phosphate (PLP) are an important class of enzymes that play a central