Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Diana P Castiblanco"'
Publikováno v:
PLoS Biology, Vol 13, Iss 12, p e1002321 (2015)
Antibodies stand between us and pathogens. Viruses mutate quickly to avoid detection, and antibodies mutate at similar rates to hunt them down. This death spiral is fueled by specialized proteins and error-prone polymerases that change DNA sequences.
Externí odkaz:
https://doaj.org/article/245ed6e90c41412a9f6daf1a9ded73c4
Autor:
Robert W. Maul, Jennifer T. Fox, Diana P. Castiblanco, Yong Jun Choi, William W. Yang, Patricia J. Gearhart, Kimberly J. Zanotti, Huseyin Saribasak, Kyungjae Myung
Publikováno v:
The Journal of Immunology. 194:35-42
Mammalian ATPase family AAA domain–containing protein 5 (ATAD5) and its yeast homolog enhanced level of genomic instability 1 are responsible for unloading proliferating cell nuclear antigen from newly synthesized DNA. Prior work in HeLa and yeast
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 8 (2017)
Frontiers in Immunology, Vol 8 (2017)
The goal of immunization is to produce both a flood of antibodies to neutralize antigen and memory cells to accelerate the secondary response. To enhance the generation of memory B cells, we examined the effect of co-engaging BCR and toll-like recept