Stable coexistence between an archaeal virus and the dominant methanogen of the human gut

Autor: Diana P. Baquero, Sofia Medvedeva, Camille Martin-Gallausiaux, Nika Pende, Anna Sartori-Rupp, Stéphane Tachon, Thierry Pedron, Laurent Debarbieux, Guillaume Borrel, Simonetta Gribaldo, Mart Krupovic

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract The human gut virome, which is mainly composed of bacteriophages, also includes viruses infecting archaea, yet their role remains poorly understood due to lack of isolates. Here, we characterize a temperate archaeal virus (MSTV1) infecting M

Externí odkaz: https://doaj.org/article/c3792dc0ab7d410fa765f86c1a8e505f

Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10

Autor: Mohamed Ahmed, Jared Mackenzie, Liku Tezera, Robert Krause, Barry Truebody, Diana Garay-Baquero, Andres Vallejo, Katya Govender, John Adamson, Hayden Fisher, Jonathan W. Essex, Salah Mansour, Paul Elkington, Adrie J. C. Steyn, Alasdair Leslie

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)

Mycobacterium tuberculosis senses IFN-γ via the membrane protein MmpL10, which results in stimulation of bacterial respiration and virulence gene expression, worsens infection and paradoxically prevents the formation of isoniazid tolerant persisters

Externí odkaz: https://doaj.org/article/46f025f3b82648ada03fe8702e70e007

Cbp1-Cren7 chromatinization of CRISPR arrays favours transcription from leader-over cryptic promoters

Autor: Fabian Blombach, Michal Sýkora, Jo Case, Xu Feng, Diana P Baquero, Thomas Fouqueau, Duy Khanh Phung, Declan Barker, Mart Krupovic, Qunxin She, Finn Werner

CRISPR arrays form the physical memory of CRISPR adaptive immune systems by incorporating foreign DNA as spacers that are often AT-rich and derived from viruses. As promoter elements such as the TATA-box are AT-rich, CRISPR arrays are prone to harbou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72ea9b779ff77a45b1b1abd170c177a9
https://doi.org/10.1101/2023.03.24.534125

Egress of archaeal viruses

Autor: David Prangishvili, Junfeng Liu, Diana P. Baquero

Publikováno v: Cellular Microbiology. 23

Viruses of Archaea, arguably the most mysterious part of the virosphere due to their unique morphotypes and genome contents, exploit diverse mechanisms for releasing virus progeny from the host cell. These include virus release as a result of the enz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c6da598bd90b694c97c00831795c825
https://doi.org/10.1111/cmi.13394

Virus-induced cell gigantism and asymmetric cell division in archaea

Autor: Diana P. Baquero, Qi Zhang, Virginija Cvirkaite-Krupovic, Yunfeng Yang, Yulong Shen, Junfeng Liu, Mart Krupovic

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (15), pp.e2022578118. ⟨10.1073/pnas.2022578118⟩
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (15), pp.e2022578118. ⟨10.1073/pnas.2022578118⟩
Proc Natl Acad Sci U S A

International audience; Archaeal viruses represent one of the most mysterious parts of the global virosphere, with many virus groups sharing no evolutionary relationship to viruses of bacteria or eukaryotes. How these viruses interact with their host

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393e2eebcc57181f31854fd25bab4674
https://doi.org/10.1073/pnas.2022578118