Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Diana N, Pak"'
Autor:
Richard L Frock, Steven C Chen, Dao-Fu Da, Ellie Frett, Carmen Lau, Christina Brown, Diana N Pak, Yuexia Wang, Antoine Muchir, Howard J Worman, Luis F Santana, Warren C Ladiges, Peter S Rabinovitch, Brian K Kennedy
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42918 (2012)
Lmna(-/-) mice display multiple tissue defects and die by 6-8 weeks of age reportedly from dilated cardiomyopathy with associated conduction defects. We sought to determine whether restoration of lamin A in cardiomyocytes improves cardiac function an
Externí odkaz:
https://doaj.org/article/474b2d0db8044ac2a121f210bd305299
Autor:
Richard L. Frock, Steven C. Chen, Dao-Fu Dai, Ellie Frett, Carmen Lau, Christina Brown, Diana N. Pak, Yuexia Wang, Antoine Muchir, Howard J. Worman, Luis F. Santana, Warren C. Ladiges, Peter S. Rabinovitch, Brian K. Kennedy
Publikováno v:
PLoS ONE, Vol 7, Iss 9 (2012)
Externí odkaz:
https://doaj.org/article/29d9bcf7338142eb8ccdd8273928f023
Autor:
Erica D. Smith, Mitsuhiro Tsuchiya, Nick Dang, Di Hu, Matt Kaeberlein, Diana N. Pak, James H. Thomas, Lindsay A. Fox, Daniel E. L. Promislow, Brian K. Kennedy, Emily O. Kerr, Elijah D. Johnston, K. Linnea Welton, Bie N. Tchao
Publikováno v:
Genome Research. 18:564-570
Studies in invertebrate model organisms have been a driving force in aging research, leading to the identification of many genes that influence life span. Few of these genes have been examined in the context of mammalian aging, however, and it remain
Autor:
Brady Olsen, Marc K. Ting, Simon C. Johnson, Annie Chou, Dennis Wang, Monika Jelic, Zhongjun Zhou, Dillon Pruett, Eric C. Liao, Sarani Goswami, Mitsuhiro Tsuchiya, Ariana A. Rodriguez, Arieanna C. Anies, Theodor K. Bammler, Elroy H. An, Sylvia Sim, Diana N. Pak, Kristan K. Steffen, Juniper K. Pennypacker, Kim M. Pham, Christopher F. Bennett, Helen Vander Wende, Richard M. Moller, Bopharoth Ros, Tom Pollard, Richard P. Beyer, Mark A. McCormick, Winston Lo, Joe R. Delaney, Jennifer Schleit, Shannon Klum, Diana Kim, Anthony S. Castanza, Rachel B. Brem, Ki Soo Jeong, Benjamin L. Spector, Daniel B. Carr, Brian M. Wasko, K. Linnea Welton, Eric A. Westman, Donna Prunkard, Scott Tsuchiyama, Katie Kirkland, Amrita Solanky, Dilreet Rai, Shiena Enerio, Christopher J. Murakami, Manpreet K. Singh, Marissa Fletcher, Anna Shemorry, George L. Sutphin, Elijah D. Johnston, Molly A. Holmberg, Zhao Jun Peng, Lindsay A. Fox, Sean Higgins, Yousin Suh, Michael Lim, Dan Lockshon, Jin Kim, Jessica Hui, Erica D. Smith, Eunice Choi, Brian Muller, Xinguang Liu, Soumya Kotireddy, Nick Dang, Hillary Miller, Prarthana Pradeep, Di Hu, Brett Robison, Brian K. Kennedy, Matt Kaeberlein, Katie Snead, Michael Sage, Emily O. Kerr, Michael S. Lin, Umema Ahmed, Bie N. Tchao, Jonathan A. Oakes, Adrienne M. Wang
Publikováno v:
Cell metabolism. 22(5)
SummaryMany genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We performed a systematic analysis of yeast RLS in a set of 4,698 viable s
Autor:
Brian K. Kennedy, Annie Chou, Kim M. Pham, Jennifer Schleit, Daniel B. Carr, Monika Jelic, Zhongjun Zhou, Xinguang Liu, Simon C. Johnson, Elroy H. An, Kristan K. Steffen, Qi Peng, Joe R. Delaney, Diana N. Pak, Zhao J. Peng, Brett Robison, Chris Raabe, Jin R. Kim, Eunice Choi, Ben W. Dulken, Matt Kaeberlein, Christopher J. Murakami, Yousin Suh, George L. Sutphin, Daniel Lockshon, Sylvia Sim, Bin Liu, Marissa Fletcher, Mitsuhiro Tsuchiya, Amrita Solanky, Richard M. Moller, Michael Sage, Scott Tsuchiyama
Publikováno v:
Aging Cell. 10:1089-1091
Combining two or more longevity-altering interventions and determining the resulting effect on lifespan is a common method for examining the relationship between such interventions. An important subset of this type of analysis occurs when one of the
Autor:
Christina Brown, Warren C. Ladiges, Diana N. Pak, Howard J. Worman, Dao Fu Da, Luis Fernando Santana, Yuexia Wang, Richard L. Frock, Ellie Frett, Steven C. Chen, Brian K. Kennedy, Antoine Muchir, Peter S. Rabinovitch, Carmen Lau
Publikováno v:
PloS one, vol 7, iss 8
PLoS ONE
PLoS ONE, Vol 7, Iss 8, p e42918 (2012)
PLoS ONE
PLoS ONE, Vol 7, Iss 8, p e42918 (2012)
Lmna(-/-) mice display multiple tissue defects and die by 6-8 weeks of age reportedly from dilated cardiomyopathy with associated conduction defects. We sought to determine whether restoration of lamin A in cardiomyocytes improves cardiac function an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d60a1d5403ac54da74e162f97c7430
https://escholarship.org/uc/item/8k60g47z
https://escholarship.org/uc/item/8k60g47z
Autor:
Joe R, Delaney, George L, Sutphin, Ben, Dulken, Sylvia, Sim, Jin R, Kim, Brett, Robison, Jennifer, Schleit, Christopher J, Murakami, Daniel, Carr, Elroy H, An, Eunice, Choi, Annie, Chou, Marissa, Fletcher, Monika, Jelic, Bin, Liu, Daniel, Lockshon, Richard M, Moller, Diana N, Pak, Qi, Peng, Zhao J, Peng, Kim M, Pham, Michael, Sage, Amrita, Solanky, Kristan K, Steffen, Mitsuhiro, Tsuchiya, Scott, Tsuchiyama, Simon, Johnson, Chris, Raabe, Yousin, Suh, Zhongjun, Zhou, Xinguang, Liu, Brian K, Kennedy, Matt, Kaeberlein
Publikováno v:
Aging cell. 10(6)
Activation of Sir2-orthologs is proposed to increase lifespan downstream of dietary restriction (DR). Here we describe an examination of the effect of 32 different lifespan-extending mutations and four methods of dietary restriction on replicative li
Autor:
Nick Dang, Brian K. Kennedy, Matt Kaeberlein, Lindsay A. Fox, Vivian L. MacKay, Jonathan A. Oakes, Emily O. Kerr, Stanley Fields, Diana N. Pak, Mitsuhiro Tsuchiya, Bie N. Tchao, Di Hu, Elijah D. Johnston, Kristan K. Steffen
Publikováno v:
Cell. (2):292-302
SummaryIn nearly every organism studied, reduced caloric intake extends life span. In yeast, span extension from dietary restriction is thought to be mediated by the highly conserved, nutrient-responsive target of rapamycin (TOR), protein kinase A (P