Combinatorial Intracellular Delivery Screening of Anticancer Drugs

Autor: Edoardo Scarpa, Diana Moreira Leite, Aroa Duro-Castano, Belen Sola-Barrado, Giuseppe Battaglia

Publikováno v: Molecular Pharmaceutics

Conventional drug solubilization strategies limit the understanding of the full potential of poorly water-soluble drugs during drug screening. Here, we propose a screening approach in which poorly water-soluble drugs are entrapped in poly(2-(methacry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40caae7ead2b6483e844cc844361b4e
https://hdl.handle.net/2434/964456

The Role of BAR Proteins and the Glycocalyx in Brain Endothelium Transcytosis

Autor: Giuseppe Battaglia, Diana Matias, Diana Moreira Leite

Publikováno v: Cells
Cells, Vol 9, Iss 2685, p 2685 (2020)

Within the brain, endothelial cells lining the blood vessels meticulously coordinate the transport of nutrients, energy metabolites and other macromolecules essential in maintaining an appropriate activity of the brain. While small molecules are pump

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b061c425755f10b8940a075bd8ce9b03
https://pubmed.ncbi.nlm.nih.gov/33327645

The role of syndapin-2 mediated transcytosis across the blood-brain barrier on amyloid-β accumulation in the brain

Autor: Jerome D. Swinny, Filomain Nguemo, Giuseppe Battaglia, Diana Moreira Leite, Lorena Ruiz-Pérez, Mohese Seifi, Markus Plomann

A deficient transport of amyloid-(Aβ) across the blood-brain barrier (BBB), and its diminished clearance from the brain, contributes to neurodegenerative and vascular pathologies, including Alzheimer’s (AD) and cerebral angiopathy, respectively. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3a0d694de57ff23ce3c46d49b766948
https://doi.org/10.1101/2020.07.12.199869

A human co‐culture cell model incorporating microglia supports glioblastoma growth and migration, and confers resistance to cytotoxics

Autor: Geoffrey J. Pilkington, Mark Gumbleton, Barbara Zvar Baskovic, Catia Neto, Prospero Civita, Diana Moreira Leite

Publikováno v: Leite, D M, Zvar Baskovic, B, Civita, P, Neto, C, Gumbleton, M & Pilkington, G J 2020, ' A human co-culture cell model incorporating microglia supports glioblastoma growth and migration, and confers resistance to cytotoxics ', FASEB Journal, vol. 34, no. 1, pp. 1710-1727 . https://doi.org/10.1096/fj.201901858RR

Despite the importance of the tumor microenvironment in regulating tumor progression, few in vitro models have been developed to understand the effects of non‐neoplastic cells and extracellular matrix (ECM) on drug resistance in glioblastoma (GBM)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a30c0a0745c0253e18e03718b65d6a
https://researchportal.port.ac.uk/ws/files/18206015/A_human_co_culture_cell_model.pdf

PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal brain ischemia

Autor: Sofia Duque Santos, Miguel Xavier, Helena Tomás, Marília Torrado, Rita Castro, João Rodrigues, Ana Paula Pêgo, Victoria Leiro, Beatriz Custódio, Débora A. Moreira, Diana Moreira Leite

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Drug delivery to the central nervous system is restricted by the blood-brain barrier (BBB). However, with the onset of stroke, the BBB becomes leaky, providing a window of opportunity to passively target the brain. Here, cationic poly(amido amine) (P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffc51ae1a53490a51f6137c7a8027de