Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Diana Martins Bordalo"'
NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart
Autor:
Marion Müller, Rose Eghbalian, Jes-Niels Boeckel, Karen S. Frese, Jan Haas, Elham Kayvanpour, Farbod Sedaghat-Hamedani, Maximilian K. Lackner, Oguz F. Tugrul, Thomas Ruppert, Rewati Tappu, Diana Martins Bordalo, Jasmin M. Kneuer, Annika Piekarek, Sabine Herch, Sarah Schudy, Andreas Keller, Nadja Grammes, Cornelius Bischof, Anna Klinke, Margarida Cardoso-Moreira, Henrik Kaessmann, Hugo A. Katus, Norbert Frey, Lars M. Steinmetz, Benjamin Meder
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Phosphorylation of the essential myosin light chain (ELC) influence actin-myosin crossbridge cycling in the heart. Here, the authors show upregulated ELC-phosphorylation in systolic heart failure and identify NIMArelated kinase 9 to bind to ELC media
Externí odkaz:
https://doaj.org/article/bdd3c98ae2ae446c8307d5af259ac8e7
Autor:
Jan Haas, Stefan Mester, Alan Lai, Karen S Frese, Farbod Sedaghat‐Hamedani, Elham Kayvanpour, Tobias Rausch, Rouven Nietsch, Jes‐Niels Boeckel, Avisha Carstensen, Mirko Völkers, Carsten Dietrich, Dietmar Pils, Ali Amr, Daniel B Holzer, Diana Martins Bordalo, Daniel Oehler, Tanja Weis, Derliz Mereles, Sebastian Buss, Eva Riechert, Emil Wirsz, Maximilian Wuerstle, Jan O Korbel, Andreas Keller, Hugo A Katus, Andreas E Posch, Benjamin Meder
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 1, Pp 107-120 (2018)
Abstract The transcriptome needs to be tightly regulated by mechanisms that include transcription factors, enhancers, and repressors as well as non‐coding RNAs. Besides this dynamic regulation, a large part of phenotypic variability of eukaryotes i
Externí odkaz:
https://doaj.org/article/4481e23c5007408586f68c9d973d8b8f
Autor:
Jes-Niels Boeckel, Maximilian Nicolas Moebius-Winkler, Marion Müller, Sabine Rebs, Nicole Eger, Laura Schoppe, Rewatti Tappu, Karoline Elizabeth Kokot, Jasmin M Kneuer, Susanne Gaul, diana martins bordalo, alain lai, Jan Haas, Mahsa Ghanbari, Philipp Drewe-Boss, Martin Liss, Hugo A Katus, Uwe Ohler, Michael gotthardt, Ulrich Laufs, Katrin Streckfuß-Bömeke, Benjamin Meder
Publikováno v:
Circulation. 144
Introduction: The versatility of the human genome is increased by the process of alternative mRNA splicing. Impaired splicing of the cardiac transcriptome is involved in the pathophysiology of heart failure. Especially, mutations in cardiac-specific
Autor:
Michael Gotthardt, Jes-Niels Boeckel, Mahsa Ghanbari, Maximilian Möbius-Winkler, Martin Liss, Jasmin M Kneuer, Uwe Ohler, Philipp Drewe-Boss, Sabine Rebs, Alan Lai, Katrin Streckfuss-Bömeke, Nicole Eger, Karoline E. Kokot, Laura Schoppe, Rewati Tappu, Jan Haas, Ulrich Laufs, Diana Martins Bordalo, Susanne Gaul, Marion Müller, Hugo A. Katus, Benjamin Meder
Publikováno v:
Genomics, proteomicsbioinformatics. 20(1)
Alternative mRNA splicing is a fundamental process to increase the versatility of the genome. In humans, cardiac mRNA splicing is involved in the pathophysiology of heart failure. Mutations in the splicing factor RNA binding motif protein 20 (RBM20)
Autor:
Andreas E. Posch, Avisha Carstensen, Ali Amr, Mirko Völkers, Emil Wirsz, Daniel B. Holzer, Hugo A. Katus, Alan Lai, Carsten Dietrich, Farbod Sedaghat-Hamedani, Sebastian J. Buss, Elham Kayvanpour, Daniel Oehler, Karen S. Frese, Dietmar Pils, Jan O. Korbel, Jan Haas, Maximilian Wuerstle, Tobias Rausch, Diana Martins Bordalo, Stefan Mester, Eva Riechert, Andreas Keller, Tanja Weis, Derliz Mereles, Jes-Niels Boeckel, Benjamin Meder, Rouven Nietsch
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 10, Iss 1, Pp 107-120 (2018)
EMBO Molecular Medicine, Vol 10, Iss 1, Pp 107-120 (2018)
The transcriptome needs to be tightly regulated by mechanisms that include transcription factors, enhancers, and repressors as well as non‐coding RNAs. Besides this dynamic regulation, a large part of phenotypic variability of eukaryotes is express
Autor:
Christina Scheiner, Dietmar Pils, Daniel B. Holzer, Andrea S. Bauer, Johannes Backs, Andreas Keller, Carsten Dietrich, Arjang Ruhparwar, Alan Lai, Benjamin Meder, Hugo A. Katus, Farbod Sedaghat-Hamedani, Ali Amr, Matthias Mueller-Hennessen, Rouven Nietsch, Dieter Weichenhan, Maximilian Wuerstle, Tanja Weis, Jan Haas, Hauke Hund, Stefan Mester, Elham Kayvanpour, Diana Martins Bordalo, Andreas E. Posch, Dominik Siede, Christoph Plass, Karen S. Frese
Publikováno v:
Circulation. 136:1528-1544
Background: Biochemical DNA modification resembles a crucial regulatory layer among genetic information, environmental factors, and the transcriptome. To identify epigenetic susceptibility regions and novel biomarkers linked to myocardial dysfunction
NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart
Autor:
Marion Müller, Rose Eghbalian, Jes-Niels Boeckel, Karen S. Frese, Jan Haas, Elham Kayvanpour, Farbod Sedaghat-Hamedani, Maximilian K. Lackner, Oguz F. Tugrul, Thomas Ruppert, Rewati Tappu, Diana Martins Bordalo, Jasmin M. Kneuer, Annika Piekarek, Sabine Herch, Sarah Schudy, Andreas Keller, Nadja Grammes, Cornelius Bischof, Anna Klinke, Margarida Cardoso-Moreira, Henrik Kaessmann, Hugo A. Katus, Norbert Frey, Lars M. Steinmetz, Benjamin Meder
Publikováno v:
Nature communications. 13(1)
To adapt to changing hemodynamic demands, regulatory mechanisms modulate actin-myosin-kinetics by calcium-dependent and -independent mechanisms. We investigate the posttranslational modification of human essential myosin light chain (ELC) and identif
Autor:
Benjamin Meder, S M Mester, Elham Kayvanpour, A K Keller, Karen S. Frese, Jes-Niels Boeckel, J K Korbel, Hugo A. Katus, Carsten Dietrich, Alan Lai, Jan Haas, Diana Martins Bordalo, Farbod Sedaghat-Hamedani, A P Posch, Ali Amr
Publikováno v:
European Heart Journal. 39
Autor:
Yuhua Liao, Alan Lai, Christoph Dieterich, Jan Haas, Diana Martins Bordalo, Sabine Haßfeld, Omid Shirvani Samani, Min Wang, Qiutang Zeng, Feng Zhu, Li Yuan, Hugo A. Katus, Min Zhou, Michael Gotthardt, Regina Pribe-Wolferts, Benjamin Meder, Tobias Fehlmann, Ali Amr, Daniel Tian Li, Kai Huang, Ming Nie, Martin Liss, Zihua Zhou, Marion Müller, Katrin Streckfuß-Bömeke, Christine Schwartz, Jing Wang, Elham Kayvanpour, Christian Geier, Andreas Keller, Karen S. Frese, Yan-Wen Shu, Jing Shao, Avisha Carstensen, Philipp Ehlermann, Christine Fischer, Farbod Sedaghat-Hamedani, Long-Xian Cheng
Publikováno v:
European heart journal. 38(46)
Aims: In this study, we aimed to clinically and genetically characterize LVNC patients and investigate the prevalence of variants in known and novel LVNC disease genes. Introduction: Left ventricular non-compaction cardiomyopathy (LVNC) is an increas