Gut barrier dysfunction and the risk of ICU-acquired bacteremia- a case–control study

Autor: Meri R. J. Varkila, Diana M. Verboom, Lennie P. G. Derde, Tom van der Poll, Marc J. M. Bonten, Olaf L. Cremer, the MARS consortium

Publikováno v: Annals of Intensive Care, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract Background Impaired intestinal barrier function can enable passage of enteric microorganisms into the bloodstream and lead to nosocomial bloodstream infections during critical illness. We aimed to determine the relative importance of gut tra

Externí odkaz: https://doaj.org/article/184a0a24672c4ca9bd68f8cca75118fb

Association between age and the host response in critically ill patients with sepsis

Autor: Erik H A, Michels, Joe M, Butler, Tom D Y, Reijnders, Olaf L, Cremer, Brendon P, Scicluna, Fabrice, Uhel, Hessel, Peters-Sengers, Marcus J, Schultz, Julian C, Knight, Lonneke A, van Vught, Tom, van der Poll, Diana M, Verboom

Publikováno v: Critical care (London, England). 26(1)

The association of ageing with increased sepsis mortality is well established. Nonetheless, current investigations on the influence of age on host response aberrations are largely limited to plasma cytokine levels while neglecting other pathophysiolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fe1d6fd8595b0d5b958e16fe985b3abc
https://pubmed.ncbi.nlm.nih.gov/36514130

Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis

Autor: Lonneke A. van Vught, Fabrice Uhel, Chao Ding, Cees van‘t Veer, Brendon P. Scicluna, Hessel Peters‐Sengers, Peter M.C. Klein Klouwenberg, Peter Nürnberg, Olaf L. Cremer, Marcus J. Schultz, Tom van der Poll, Friso M. de Beer, Lieuwe D.J. Bos, Gerie J. Glas, Arie J. Hoogendijk, Roosmarijn T.M. van Hooijdonk, Janneke Horn, Mischa A. Huson, Laura R.A. Schouten, Marleen Straat, Luuk Wieske, Maryse A. Wiewel, Esther Witteveen, Marc J.M. Bonten, Olaf M. Cremer, David S.Y. Ong, Jos F. Frencken, Maria E. Koster‐Brouwer, Kirsten van de Groep, Diana M. Verboom

Publikováno v: Journal of Thrombosis and Haemostasis, 19(4), 1049-1063. Wiley-Blackwell
van Vught, L A, Uhel, F, Ding, C, van‘t Veer, C, Scicluna, B P, Peters-Sengers, H, Klein Klouwenberg, P M C, Nürnberg, P, Cremer, O L, the MARS consortium, Schultz, M J, van der Poll, T, de Beer, F M, Bos, L D J, Glas, G J, Hoogendijk, A J, van Hooijdonk, R T M, Horn, J, Huson, M A, Schouten, L R A, Scicluna, B P, Straat, M, van Vught, L A, Wieske, L, Wiewel, M A, Witteveen, E, Bonten, M J M, Cremer, O M, Ong, D S Y, Frencken, J F, Klein Klouwenberg, P M C, Koster-Brouwer, M E, van de Groep, K & Verboom, D M 2021, ' Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis ', Journal of Thrombosis and Haemostasis, vol. 19, no. 4, pp. 1049-1063 . https://doi.org/10.1111/jth.15246
Journal of thrombosis and haemostasis, 19(4), 1049-1063. Wiley-Blackwell
Journal of Thrombosis and Haemostasis

Background: A prolonged prothrombin time (PT) is a common feature in sepsis indicating consumptive coagulopathy.
Objectives: To determine the association between a prolonged PT and aberrations in other host response mechanisms in sepsis.
Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369a4a6ef9a516b682c2fd116d7be04d
https://research.vumc.nl/en/publications/0691034d-5a10-4a96-8bd4-8492dcca203b

Profile of the SeptiCyte™ LAB gene expression assay to diagnose infection in critically ill patients

Autor: M. J. M. Bonten, Diana M. Verboom, Marlies E. Koster-Brouwer, Olaf L. Cremer, Meri R.J. Varkila

Publikováno v: Expert Review of Molecular Diagnostics, 19(2), 95. Expert Reviews Ltd.

Sepsis is a severe and frequently occurring clinical syndrome, caused by the inflammatory response to infections. Recent studies on the human transcriptome during sepsis have yielded several gene-expression assays that might assist physicians during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbbd092b6033dd6f5b2fa7810f5e80c
https://dspace.library.uu.nl/handle/1874/390107

Adalimumab provides long-lasting clinical improvement in refractory mucocutaneous Behçet's disease without formation of antidrug antibodies

Autor: Diana M, Verboom, Tim B, van der Houwen, Jasper H, Kappen, Paul L A, van Daele, Willem A, Dik, Marco W J, Schreurs, P Martin, van Hagen, Jan A M, van Laar

Publikováno v: Clinical and experimental rheumatology. 37(6)

The TNF-blocker adalimumab can be effective in Behçet's disease (BD), a multisystem auto-inflammatory disorder. Unfortunately, the therapeutic efficacy of TNF-blockers can be hampered by the formation of anti-drug antibodies. We present an observati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba3956453d544001ef36c3ef1c7769cb
https://pubmed.ncbi.nlm.nih.gov/30873952