Výsledky vyhledávání - "Diana M. Steel"

Posttranscriptional Regulation of Acute Phase Serum Amyloid A2 Expression by the 5′- and 3′-Untranslated Regions of Its mRNA

Autor: Daniel B. Longley, Diana M. Steel, Alexander S. Whitehead

Publikováno v: The Journal of Immunology. 163:4537-4545

Human acute-phase serum amyloid A protein (A-SAA) is a major acute phase reactant, the concentration of which increases dramatically as part of the body’s early response to inflammation. A-SAA is the product of two almost identical genes, SAA1 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89fd8876b017a345dcf7305a53553cec
https://doi.org/10.4049/jimmunol.163.8.4537

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Use of the acute phase serum amyloid A2 (SAA2) gene promoter in the analysis of pro- and anti-inflammatory mediators: differential kinetics of SAA2 promoter induction by IL-1β and TNF-α compared to IL-6

Autor: Alexander S. Whitehead, Alexander Steinkasserer, Sharon Grehan, Clarissa M. Uhlar, Diana M. Steel

Publikováno v: Journal of Immunological Methods. 203:123-130

A cytokine responsive construct, pGL2-SAA2pt, was generated by cloning the acute phase promoter of human serum amyloid A2 (SAA2) upstream of a luciferase reporter gene. The construct responds to the inflammatory mediators MoCM, IL-1 beta, TNF-alpha,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acaf1283e775f8bbbde525198fed8658
https://doi.org/10.1016/s0022-1759(96)00220-7

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Expression and Regulation of Constitutive and Acute Phase Serum Amyloid A mRNAs in Hepatic and Non‐Hepatic Cell Lines

Autor: F. C. Donoghue, R. M. O'neill, Clarissa M. Uhlar, Alexander S. Whitehead, Diana M. Steel

Publikováno v: Scandinavian Journal of Immunology. 44:493-500

'Acute phase' and 'constitutive' SAA (A-SAA and C-SAA, respectively) mRNA levels were measured in hepatic and non-hepatic cell lines after treatment with monocyte conditioned medium (MoCM), with or without dexamethasone (Dex). A-SAA mRNAs were detect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8cb4e23b701c9d8827af10ca9eb0ab
https://doi.org/10.1046/j.1365-3083.1996.d01-341.x

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The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein

Autor: Diana M. Steel, Alexander S. Whitehead

Publikováno v: Immunology Today. 15:81-88

Following an acute phase stimulus, such as infection or physical injury, many liver-derived plasma proteins are increased in concentration. These provide enhanced protection against invading micro-organisms, limit tissue damage and promote a rapid re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7a010c518297d4387b558acab3b6b4
https://doi.org/10.1016/0167-5699(94)90138-4

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Ribozyme mediated cleavage of acute phase serum amyloid A (A-SAA) mRNA in vitro

Autor: Diana M. Steel, Derval J. Gaughan, Alexander S. Whitehead

Publikováno v: FEBS letters. 374(2)

The 1000-fold induction of acute phase serum amyloid A (A-SAA) in the liver during inflammation indicates that this protein plays an important, though ill-defined, role in host defence. Paradoxically, prolonged overproduction of A-SAA is a causative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a360fcd0749389c92beff03c6eeed9de
https://pubmed.ncbi.nlm.nih.gov/7589544

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Biosynthesis of human acute-phase serum amyloid A protein (A-SAA) in vitro: the roles of mRNA accumulation, poly(A) tail shortening and translational efficiency

Autor: F C DeBeer, Jack T. Rogers, Diana M. Steel, Alexander S. Whitehead, M C DeBeer

Human ‘acute-phase’ serum amyloid A protein (A-SAA) is a major acute-phase reactant (APR) and an apolipoprotein of high density lipoprotein 3 (HDL3). We have examined several parameters of A-SAA biosynthesis in PLC/PRF/5 hepatoma cells in respons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b5a9766af88cbda60031e364ef5f98
https://europepmc.org/articles/PMC1132425/

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A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2)

Autor: Alexander S. Whitehead, Fred C. DeBeer, Grant C. Sellar, Diana M. Steel, Susan Simon, Clarissa M. Uhlar

Publikováno v: Genomics. 16(2)

The acute-phase reactant serum amyloid A (SAA) is a polymorphic apolipoprotein encoded by a family of highly homologous and closely linked genes: SAA1, SAA2, and SAA3. We have isolated a human genomic cosmid clone containing the gene encoding a fourt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf72e0d0fa579dd5792e0960f602f2e7
https://pubmed.ncbi.nlm.nih.gov/7686132

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Nucleotide sequence and expression of the human gene encoding apolipoprotein H (beta 2-glycoprotein I)

Autor: Les Walker, Haider Mehdi, Michael Nunn, Mark E. Peeples, Diana M. Steel, Alexander S. Whitehead, Perez Mary S

Publikováno v: Gene. 108(2)

Human apolipoprotein H (ApoH), also called β2-glycoprotein I, is a 50-kDa serum glycoprotein whose function is not clearly defined. We have cloned and sequenced ApoH cDNAs both from human liver and from a human hepatoma cell line (HepG2). Both cDNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ca5dbd2a0cfb178008c04b675fbcb7
https://pubmed.ncbi.nlm.nih.gov/1748314

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