Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Diana M. Lindquist"'
Autor:
Valeria Rudman-Melnick, Mike Adam, Kaitlynn Stowers, Andrew Potter, Qing Ma, Saagar M. Chokshi, Davy Vanhoutte, Iñigo Valiente-Alandi, Diana M. Lindquist, Michelle L. Nieman, J. Matthew Kofron, Eunah Chung, Joo-Seop Park, S. Steven Potter, Prasad Devarajan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Examining kidney fibrosis is crucial for mechanistic understanding and developing targeted strategies against chronic kidney disease (CKD). Persistent fibroblast activation and tubular epithelial cell (TEC) injury are key CKD contributors. H
Externí odkaz:
https://doaj.org/article/fb7e56c701184434a55c7bc914d1b4b2
Autor:
Farrah N. Brown, Eri Iwasawa, Crystal Shula, Elizabeth M. Fugate, Diana M. Lindquist, Francesco T. Mangano, June Goto
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-19 (2023)
Abstract Background Neonatal hydrocephalus is a congenital abnormality resulting in an inflammatory response and microglial cell activation both clinically and in animal models. Previously, we reported a mutation in a motile cilia gene, Ccdc39 that d
Externí odkaz:
https://doaj.org/article/47e6231a38094abf9e1435ce3797e875
Autor:
Alicia Bedolla, Aleksandr Taranov, Fucheng Luo, Jiapeng Wang, Flavia Turcato, Elizabeth M. Fugate, Nigel H. Greig, Diana M. Lindquist, Steven A. Crone, June Goto, Yu Luo
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Two recently developed novel rodent models have been reported to ablate microglia, either by genetically targeting microglia (via Cx3cr1-creER: iDTR + Dtx) or through pharmacologically targeting the CSF1R receptor with its inhibit
Externí odkaz:
https://doaj.org/article/9e9169c511894de18604fa32ac1bba9c
Autor:
Kamyar Zahedi, Marybeth Brooks, Sharon Barone, Negah Rahmati, Tracy Murray Stewart, Matthew Dunworth, Christina Destefano-Shields, Nupur Dasgupta, Steve Davidson, Diana M. Lindquist, Christine E. Fuller, Roger D. Smith, John L. Cleveland, Robert A. Casero, Manoocher Soleimani
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-21 (2020)
Abstract Background Polyamine catabolism plays a key role in maintaining intracellular polyamine pools, yet its physiological significance is largely unexplored. Here, we report that the disruption of polyamine catabolism leads to severe cerebellar d
Externí odkaz:
https://doaj.org/article/e46b17a9098241a499821fe366620d0f
Autor:
Hong-Ru Chen, Xiaohui Zhang-Brotzge, Yury M. Morozov, Yuancheng Li, Siming Wang, Helen Heju Zhang, Irena S. Kuan, Elizabeth M. Fugate, Hui Mao, Yu-Yo Sun, Pasko Rakic, Diana M. Lindquist, Ton DeGrauw, Chia-Yi Kuan
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
The creatine transporter (CrT) maintains brain creatine (Cr) levels, but the effects of its deficiency on energetics adaptation under stress remain unclear. There are also no effective treatments for CrT deficiency, the second most common cause of X-
Externí odkaz:
https://doaj.org/article/927d1c1aefe84c5fbf121667460aa626
Autor:
Robert K. McNamara, Jessica Able, Ronald Jandacek, Therese Rider, Patrick Tso, Diana M. Lindquist
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 3, Pp 405-411 (2009)
To investigate the effects of omega-3 fatty acid deficiency on phosphatidylinositol signaling in brain, myo-inositol (mI) concentrations were determined in the prefrontal cortex (PFC) of omega-3 fatty acid deficient rats by in vivo proton magnetic re
Externí odkaz:
https://doaj.org/article/a38337b325074b1f9cba18669fb10905
Autor:
Valeria Rudman-Melnick, Mike Adam, Kaitlynn Stowers, Andrew Potter, Qing Ma, Saagar M. Chokshi, Davy Vanhoutte, Iñigo Valiente-Alandi, Diana M. Lindquist, Michelle L. Nieman, J. Matthew Kofron, S. Steven Potter, Prasad Devarajan
Examining kidney fibrosis is crucial for mechanistic understanding and developing targeted strategies against chronic kidney disease (CKD). Persistent fibroblast activation and tubular epithelial cell (TEC) injury are key CKD contributors. However, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34ae0cac9de9cdfb10012822221312a6
https://doi.org/10.21203/rs.3.rs-2880248/v1
https://doi.org/10.21203/rs.3.rs-2880248/v1
Autor:
Shana O. Warner, Yufei Dai, Nicole Sheanon, Michael V. Yao, Rebecca L. Cason, Shahriar Arbabi, Shailendra B. Patel, Diana M. Lindquist, Jason J. Winnick
Publikováno v:
JCI Insight.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0112654e344cdd4749a1a9caf2d0dc8e
https://doi.org/10.1172/jci.insight.169789
https://doi.org/10.1172/jci.insight.169789
Autor:
Valeria Rudman-Melnick, Mike Adam, Kaitlynn Stowers, Andrew Potter, Qing Ma, Saagar M. Chokshi, Davy Vanhoutte, Iñigo Valiente-Alandi, Diana M. Lindquist, Michelle L. Nieman, J. Matthew Kofron, S. Steven Potter, Prasad Devarajan
BackgroundPersistent kidney fibroblast activation and tubular epithelial cell (TEC) injury are key contributors to CKD. However, transcriptional and cellular identities of advanced kidney disease, along with renal fibroblast specific markers and mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::081114116264b19b5592988c995238a5
https://doi.org/10.1101/2022.09.13.507855
https://doi.org/10.1101/2022.09.13.507855
Autor:
Marchelle R. Smucker, P. Ellen Grant, Rui Cao, Diana M. Lindquist, Yiming Wang, Hong-Ru Chen, Yu-Yo Sun, Yi-Min Kuo, Song Hu, Chia-Yi Kuan, Naidi Sun, Elizabeth M. Fugate
Hypothermia is the best available therapy for neonatal hypoxia-ischemia (HI) brain injury, but its primary mechanisms remain uncertain1. We hypothesize that HI induces, whereas hypothermia represses, uncoupling of oxidative-phosphorylation (OXPHOS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79e6f36d5a50633add69e0650c29e91f
https://doi.org/10.1101/2021.11.29.470404
https://doi.org/10.1101/2021.11.29.470404