Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Diana M. E. Otto"'
Autor:
Diana M. E. Otto, Ten Feizi, Jeremy E. Turnbull, María Asunción Campanero-Rhodes, Annie K. Powell, Rositsa Karamanska, Jonathan M. Blackburn, Paul R. Crocker, Nicolai V. Bovin, Robert A. Field
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Analytical Biochemistry
instname
Analytical Biochemistry
10 pag, 8 figs, 1 pags. -- Supplementary data associated with this article can be found, inthe online version, at doi:10.1016/j.ab.2010.12.036.
Here we describe a versatile high-throughput expression system that permits genome-wide screening of
Here we describe a versatile high-throughput expression system that permits genome-wide screening of
Autor:
Marko Salmi, Kristiina Aalto, Kaisa Auvinen, Yvonne Nymalm, Kati Elima, Diana M. E. Otto, Tiina A. Salminen, Erkki Koivunen, Sirpa Jalkanen, Elina Kivi, Paul R. Crocker
Publikováno v:
Blood. 114:5385-5392
Leukocytes migrate from the blood into areas of inflammation by interacting with various adhesion molecules on endothelial cells. Vascular adhesion protein-1 (VAP-1) is a glycoprotein expressed on inflamed endothelium where it plays a dual role: it i
Autor:
María Asunción Campanero-Rhodes, Robert A. Childs, M. Kiso, Paul R. Crocker, Diana M. E. Otto, Joanna Warren, Ten Feizi, Shiro Komba, Christine Le Narvor
Publikováno v:
Biochemical and Biophysical Research Communications. 344:1141-1146
Siglecs are receptors on cells of the immune, haemopoietic, and nervous systems that recognize sialyl-glycans with differing preferences for sialic acid linkage and oligosaccharide backbone sequence. We investigate here siglec binding using microarra
Autor:
Rune Blomhoff, Ralf H. Adams, Dianne Carrie, Megan Davey, C. Roland Wolf, Diana M. E. Otto, Cheryll Tickle, Colin J. Henderson, Thomas E. Gundersen
Publikováno v:
Molecular and Cellular Biology. 23:6103-6116
The cytochrome P450-dependent monooxygenase system catalyzes the metabolism of xenobiotics and endogenous compounds, including hormones and retinoic acid. In order to establish the role of these enzymes in embryogenesis, we have inactivated the syste
Autor:
Mark A. Magnuson, Dianne Carrie, Diana M. E. Otto, Colin J. Henderson, Aileen W. McLaren, Ian Rosewell, C. Roland Wolf
Publikováno v:
Journal of Biological Chemistry. 278:13480-13486
Cytochrome P450 (CYP) monooxygenases catalyze the oxidation of a large number of endogenous compounds and the majority of ingested environmental chemicals, leading to their elimination and often to their metabolic activation to toxic products. This e
Publikováno v:
Drug Metabolism Reviews. 35:385-392
Mice in which genes for drug metabolizing enzymes have been deleted or inactivated have great potential to further our understanding of the functions of these enzymes and their role in toxicology a...
Autor:
C. Roland Wolf, Neil R. Kitteringham, Helen Powell, Diana M. E. Otto, Colin J. Henderson, B. Kevin Park
Publikováno v:
Proceedings of the National Academy of Sciences. 97:12741-12745
Overdose of acetaminophen, a widely used analgesic drug, can result in severe hepatotoxicity and is often fatal. This toxic reaction is associated with metabolic activation by the P450 system to form a quinoneimine metabolite, N -acetyl- p -benzoquin
Publikováno v:
Pharmacology & Toxicology. 84:201-210
Gene expression of cytochrome P4501A (CYP1A) in the rainbow trout Oncorhynchus mykiss is dependent on aromatic hydrocarbon receptor signal transduction, and is markedly sensitive to tissue thiol status. Tissue glutathione (GSH) status was manipulated
Publikováno v:
Fish Physiology and Biochemistry. 16:449-457
Intraperitoneal injection of glutathione (GSH) is shown to effectively increase tissue glutathione content in two teleost species, the rainbow trout and the American eel. GSH uptake into teleost tissues is a distinct piscine feature of GSH biochemist
Publikováno v:
Chemosphere. 33:2021-2032
The uptake of polychlorinated biphenyl (PCB) congeners was monitored in rainbow trout caged during the dredging operation of General Motors at its Superfund site in Massena, New York. Trout were caged at the GM site and at a reference (control) site