Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Diana M Munoz"'
Autor:
Elsa Beyer Krall, Belinda Wang, Diana M Munoz, Nina Ilic, Srivatsan Raghavan, Matthew J Niederst, Kristine Yu, David A Ruddy, Andrew J Aguirre, Jong Wook Kim, Amanda J Redig, Justin F Gainor, Juliet A Williams, John M Asara, John G Doench, Pasi A Janne, Alice T Shaw, Robert E McDonald III III, Jeffrey A Engelman, Frank Stegmeier, Michael R Schlabach, William C Hahn
Publikováno v:
eLife, Vol 6 (2017)
Externí odkaz:
https://doaj.org/article/97e06b1cb72c431b99c9fe722c7f8112
Autor:
Elsa B Krall, Belinda Wang, Diana M Munoz, Nina Ilic, Srivatsan Raghavan, Matthew J Niederst, Kristine Yu, David A Ruddy, Andrew J Aguirre, Jong Wook Kim, Amanda J Redig, Justin F Gainor, Juliet A Williams, John M Asara, John G Doench, Pasi A Janne, Alice T Shaw, Robert E McDonald III, Jeffrey A Engelman, Frank Stegmeier, Michael R Schlabach, William C Hahn
Publikováno v:
eLife, Vol 6 (2017)
Inhibitors that target the receptor tyrosine kinase (RTK)/Ras/mitogen-activated protein kinase (MAPK) pathway have led to clinical responses in lung and other cancers, but some patients fail to respond and in those that do resistance inevitably occur
Externí odkaz:
https://doaj.org/article/91aa16d9c6ee4f3db98bf405c26f0785
Autor:
Michael R. Schlabach, Frank Stegmeier, Tobias Schmelzle, William R. Sellers, Francesco Hofmann, Nicholas Keen, E. Robert McDonald, Audrey Kauffmann, Odile Weber, Rosalie de Beaumont, Daniel Rakiec, Sarah Y. Neshat, Matthew D. Shirley, Jessica Wan, Dorothee Abramowski, Antoine DeWeck, Gregory McAllister, Kristine Yu, David A. Ruddy, Javad Golji, Michael D. Jones, Joshua M. Korn, Eric Billy, Li Li, Pamela J. Cassiani, Diana M. Munoz
Correlation analysis matrix displaying features that correlate most strongly with sgRNA's having off target effects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7173657ab8c9cebbe2e61d7645ea2b63
https://doi.org/10.1158/2159-8290.22531563.v1
https://doi.org/10.1158/2159-8290.22531563.v1
Autor:
Michael R. Schlabach, Frank Stegmeier, Tobias Schmelzle, William R. Sellers, Francesco Hofmann, Nicholas Keen, E. Robert McDonald, Audrey Kauffmann, Odile Weber, Rosalie de Beaumont, Daniel Rakiec, Sarah Y. Neshat, Matthew D. Shirley, Jessica Wan, Dorothee Abramowski, Antoine DeWeck, Gregory McAllister, Kristine Yu, David A. Ruddy, Javad Golji, Michael D. Jones, Joshua M. Korn, Eric Billy, Li Li, Pamela J. Cassiani, Diana M. Munoz
Supplementary Figure Legends, Table Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb53e60107d91f1fd9557bb4a74a377e
https://doi.org/10.1158/2159-8290.22531569
https://doi.org/10.1158/2159-8290.22531569
Autor:
Michael R. Schlabach, Frank Stegmeier, Tobias Schmelzle, William R. Sellers, Francesco Hofmann, Nicholas Keen, E. Robert McDonald, Audrey Kauffmann, Odile Weber, Rosalie de Beaumont, Daniel Rakiec, Sarah Y. Neshat, Matthew D. Shirley, Jessica Wan, Dorothee Abramowski, Antoine DeWeck, Gregory McAllister, Kristine Yu, David A. Ruddy, Javad Golji, Michael D. Jones, Joshua M. Korn, Eric Billy, Li Li, Pamela J. Cassiani, Diana M. Munoz
Supplementary Figure S1. Comparison of drop out phenotypes in MKN45, RKO, HT1080 highlighting selected pan-lethal genes. Supplementary Figure S2. The genes that scored as lethal by both RNAi and CRISPR were strongly enriched for known essential genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b398466e1fca85bee6e1c3e61c9c3ad
https://doi.org/10.1158/2159-8290.22531566
https://doi.org/10.1158/2159-8290.22531566
Autor:
Pamela J. Cassiani, Odile Weber, E. Robert McDonald, Li Li, Sarah Y. Neshat, Diana M Munoz, Matthew D. Shirley, Javad Golji, William R. Sellers, Nicholas Keen, Rosalie de Beaumont, Joshua M. Korn, Eric Billy, Dorothee Abramowski, Kristine Yu, Gregory McAllister, Michael D. Jones, Audrey Kauffmann, David A. Ruddy, Jessica Wan, Daniel P. Rakiec, Frank Stegmeier, Francesco Hofmann, Tobias Schmelzle, Antoine deWeck, Michael R. Schlabach
Publikováno v:
Cancer Discovery. 6:900-913
CRISPR/Cas9 has emerged as a powerful new tool to systematically probe gene function. We compared the performance of CRISPR to RNAi-based loss-of-function screens for the identification of cancer dependencies across multiple cancer cell lines. CRISPR
Publikováno v:
Revista Colombiana de Ciencias Sociales, Vol 14, Iss 2 (2023)
Objetivo: reconocer las vivencias que tuvieron los consultantes en el proceso terapéutico y que favorecieron mantener la relación de pareja luego de una infidelidad. Metodología: estudio cualitativo, fenomenológico-hermenéutico. Se realizaron do
Externí odkaz:
https://doaj.org/article/9d31207db0e549cc9964c73cb1ca9b8b
Autor:
Andrew J. Aguirre, Pasi A. Jänne, Elsa Beyer Krall, David A. Ruddy, Kristine Yu, Alice T. Shaw, Justin F. Gainor, William C. Hahn, John G. Doench, John M. Asara, Amanda J. Redig, Jong Wook Kim, Srivatsan Raghavan, Matthew J. Niederst, Jeffrey A. Engelman, Belinda Wang, Diana M Munoz, Michael R. Schlabach, Juliet Williams, Frank Stegmeier, Nina Ilic, Robert E McDonald
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b90edbf8eaf087d40cc7c7660b3a1150
https://doi.org/10.7554/elife.18970.029
https://doi.org/10.7554/elife.18970.029
Publikováno v:
Molecular Cancer Therapeutics. 16:B21-B21
CRISPR/Cas9 has emerged as a transformative new tool to systematically probe gene function. In this study, we compare the performance of CRISPR to RNAi-based loss-of-function screens for the identification of cancer dependencies by performing paralle
Publikováno v:
Cancer Research. 70:40-40
Proliferating embryonic and tumor tissues rely on aerobic glycolysis, or the metabolism of glucose to lactate under oxygenated conditions, to assist in the synthesis of biosynthetic precursors necessary for proliferation. The reliance on aerobic glyc