Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Diana M Downs"'
Publikováno v:
Microbial Cell, Vol 11, Pp 339-352 (2024)
Defining the physiological role of a gene product relies on interpreting phenotypes caused by the lack, or alteration, of the respective gene product. Mutations in critical genes often lead to easily recognized phenotypes that can include changes in
Externí odkaz:
https://doaj.org/article/fc39ba40cef346aa9fc66aa2bef13cf8
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197703 (2018)
Microorganisms respond to a variety of metabolic perturbations by repurposing or recruiting pathways to reroute metabolic flux and overcome the perturbation. Elimination of the 2-dehydropantoate 2-reductase, PanE, both reduces total coenzyme A (CoA)
Externí odkaz:
https://doaj.org/article/57f94e155572451eb27c09c90490d89b
Autor:
Kelsey M Hodge-Hanson, Diana M Downs
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185544 (2017)
The Rid (YjgF/YER057c/UK114) protein family is a group of small, sequence diverse proteins that consists of eight subfamilies. The archetypal RidA subfamily is found in all domains, while the Rid1-7 subfamilies are present only in prokaryotes. Bacter
Externí odkaz:
https://doaj.org/article/c2ceeb3ce6a54a45a87fb66fbeed6f75
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43082 (2012)
The RidA (YjgF/YER057c/UK114) family of proteins is broadly conserved in the three domains of life yet the functional understanding of these proteins is at an early stage. Physiological studies of ridA mutant strains of Salmonella enterica provided a
Externí odkaz:
https://doaj.org/article/43cf76f3a1e3418e812403fab8367ec3
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48207 (2012)
Phosphoribosylamine (PRA) is an intermediate in the biosynthetic pathway that is common to thiamine and purines. Glutamine phosphoribosyl pyrophosphate (PRPP) amidotransferase is the product of the purF gene in Salmonella enterica and catalyzes the s
Externí odkaz:
https://doaj.org/article/a972b7709fdb4c97b639dd1d9a8bdc44
Autor:
Ronnie L. Fulton, Diana M. Downs
Publikováno v:
Microbial Cell, Vol 9, Iss 12, Pp 195-206 (2022)
Pseudomonas aeruginosa inhabits diverse environmental niches that can have varying nutrient composition. The ubiquity of this organism is facilitated by a metabolic strategy that preferentially utilizes low-energy, non-fermentable organic acids, such
Externí odkaz:
https://doaj.org/article/ddc399cd5e204cee9a3fc9bf24cc0977
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Pseudomonas aeruginosa encodes eight members of the Rid protein superfamily. PA5339, a member of the RidA subfamily, is required for full growth and motility of P. aeruginosa. Our understanding of RidA integration into the metabolic network
Externí odkaz:
https://doaj.org/article/c4c11eb829134568b1259c5f75a6cc7c
Autor:
Michael D. Paxhia, Diana M. Downs
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 2, Pp 335-344 (2019)
Pyridoxal 5′-phosphate (the active form of vitamin B6) is a cofactor that is important for a broad number of biochemical reactions and is essential for all forms of life. Organisms that can synthesize pyridoxal 5′-phosphate use either the deoxyxy
Externí odkaz:
https://doaj.org/article/74a376ee4bfe48a5ad35e273d8548d70
Publikováno v:
Yeast
The RidA subfamily of the Rid (YjgF/YER057c/UK114) superfamily of proteins is broadly distributed and found in all domains of life. RidA proteins are enamine/imine deaminases. In the organisms that have been investigated, lack of RidA results in accu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9775949041e3e1877e73dc90e00bd0
https://doi.org/10.1002/yea.3670
https://doi.org/10.1002/yea.3670