Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Diana Llopiz"'
Autor:
Flor Navarro, Noelia Casares, Celia Martín-Otal, Aritz Lasarte-Cía, Marta Gorraiz, Patricia Sarrión, Diana Llopiz, David Reparaz, Nerea Varo, Juan Roberto Rodriguez-Madoz, Felipe Prosper, Sandra Hervás-Stubbs, Teresa Lozano, Juan José Lasarte
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
The high metabolic activity and insufficient perfusion of tumors leads to the acidification of the tumor microenvironment (TME) that may inhibit the antitumor T cell activity. We found that pharmacological inhibition of the acid loader chloride/bicar
Externí odkaz:
https://doaj.org/article/dfa52afd638448c3b908195abc57de8d
Autor:
Belén Aparicio, David Repáraz, Marta Ruiz, Diana Llopiz, Leyre Silva, Enric Vercher, Patrick Theunissen, Ibon Tamayo, Cristian Smerdou, Ana Igea, Marta Santisteban, Cristina Gónzalez-Deza, Juan J. Lasarte, Sandra Hervás-Stubbs, Pablo Sarobe
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immune checkpoint inhibitor (ICI)-based immunotherapy in triple negative breast cancer (TNBC) is achieving limited therapeutic results, requiring the development of more potent strategies. Combination of ICI with vaccination strategies would enhance
Externí odkaz:
https://doaj.org/article/3a2ee2360ef7461b9bdbb51a0147e8e8
Autor:
David Repáraz, Marta Ruiz, Leyre Silva, Belén Aparicio, Josune Egea, Elizabeth Guruceaga, Daniel Ajona, Yaiza Senent, Enrique Conde, Flor Navarro, Sergio Barace, Diego Alignani, Sandra Hervás-Stubbs, Juan José Lasarte, Diana Llopiz, Pablo Sarobe
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Vaccination using optimized strategies may increase response rates to immune checkpoint inhibitors (ICI) in some tumors. To enhance vaccine potency and improve thus responses to ICI, we analyzed the gene expression profile of an immunosuppressive den
Externí odkaz:
https://doaj.org/article/53cc78736e214f2f9fa14856330d5191
Autor:
Belén Aparicio, Noelia Casares, Josune Egea, Marta Ruiz, Diana Llopiz, Sheila Maestro, Cristina Olagüe, Gloria González-Aseguinolaza, Cristian Smerdou, Ascensión López-Díaz de Cerio, Susana Inogés, Felipe Prósper, José R. Yuste, Francisco Carmona-Torre, Gabriel Reina, Juan J. Lasarte, Pablo Sarobe
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 1931-1946 (2021)
Identification of relevant epitopes is crucial for the development of subunit peptide vaccines inducing neutralizing and cellular immunity against SARS-CoV-2. Our aim was the characterization of epitopes in the receptor-binding domain (RBD) of SARS-C
Externí odkaz:
https://doaj.org/article/e9377e08089748589b0baa3afce49ead
Autor:
Kathrin Heim, Maike Hofmann, Robert Thimme, Marta Ruiz, Pablo Sarobe, Sandra Hervás-Stubbs, Bruno Sangro, Luigi Buonaguro, Beatrice Cavalluzzo, Angela Mauriello, Maria Tagliamonte, David Repáraz, Enric Vercher, Diana Llopiz, Leyre Silva, Belén Aparicio, Josune Egea, Ibon Tamayo-Uria, Jorge García-Balduz, Carla Castro, Mercedes Iñarrairaegui, Charlotte Rohrer, Catrin Tauber
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/e75aa63eaad841d5bb0638f521590de1
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2022 (2022)
Immune checkpoint inhibitors (ICI) have been used as immunotherapy for hepatocellular carcinoma (HCC) with promising but still limited results. Identification of immune elements in the tumor microenvironment of individual HCC patients may help to und
Externí odkaz:
https://doaj.org/article/a873c3b7fb44456c9baca7d51d618427
Autor:
Maria Gato-Cañas, Miren Zuazo, Hugo Arasanz, Maria Ibañez-Vea, Laura Lorenzo, Gonzalo Fernandez-Hinojal, Ruth Vera, Cristian Smerdou, Eva Martisova, Imanol Arozarena, Claudia Wellbrock, Diana Llopiz, Marta Ruiz, Pablo Sarobe, Karine Breckpot, Grazyna Kochan, David Escors
Publikováno v:
Cell Reports, Vol 20, Iss 8, Pp 1818-1829 (2017)
PDL1 blockade produces remarkable clinical responses, thought to occur by T cell reactivation through prevention of PDL1-PD1 T cell inhibitory interactions. Here, we find that PDL1 cell-intrinsic signaling protects cancer cells from interferon (IFN)
Externí odkaz:
https://doaj.org/article/0f3cd2af669a405ab718be59937c419b
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Understanding mechanisms associated to dendritic cell (DC) functions has allowed developing new antitumor therapeutic vaccination strategies. However, these vaccines have demonstrated limited clinical results. Although the low immunogenicity of tumor
Externí odkaz:
https://doaj.org/article/0081d4676bc442c9838910660c2e8051
Autor:
Lorea Villanueva, Leyre Silva, Diana Llopiz, Marta Ruiz, Tamara Iglesias, Teresa Lozano, Noelia Casares, Sandra Hervas-Stubbs, María José Rodríguez, José L. Carrascosa, Juan José Lasarte, Pablo Sarobe
Publikováno v:
OncoImmunology, Vol 7, Iss 4 (2018)
Tumor infiltrating lymphocytes have been associated with a better prognostic and with higher response rates in patients treated with checkpoint inhibiting antibodies, suggesting that strategies promoting tumor inflammation may enhance the efficacy of
Externí odkaz:
https://doaj.org/article/5a45009c311643a2aa613f6bc060200e
Autor:
Aintzane Zabaleta, Delia D'Avola, Itziar Echeverria, Diana Llopiz, Leyre Silva, Lorea Villanueva, José Ignacio Riezu-Boj, Esther Larrea, Alexander Pereboev, Juan José Lasarte, Iago Rodriguez-Lago, Mercedes Iñarrairaegui, Bruno Sangro, Jesús Prieto, Pablo Sarobe
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
The lack of antiviral cellular immune responses in patients with chronic hepatitis C virus (HCV) infection suggests that T-cell vaccines may provide therapeutic benefit. Due to the central role that dendritic cells (DC) play in the activation of T-ce
Externí odkaz:
https://doaj.org/article/a824b1a51cd6450d8b80d26a263f2b52