Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Diana L. Takahashi"'
Autor:
Darian T. Carroll, Allie Miller, Jennifer Fuhr, Joseph M. Elsakr, Valerie Ricciardi, Alexa N. Del Bene, Stedman Stephens, Evan Krystofiak, Sarah R. Lindsley, Melissa Kirigiti, Diana L. Takahashi, Tyler A. Dean, Stephanie R. Wesolowski, Carrie E. McCurdy, Jacob E. Friedman, Kjersti M. Aagaard, Paul Kievit, Maureen Gannon
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionUsing a non-human primate (NHP) model of maternal Western-style diet (mWSD) feeding during pregnancy and lactation, we previously reported altered offspring beta:alpha cell ratio in vivo and insulin hyper-secretion ex vivo. Mitochondria a
Externí odkaz:
https://doaj.org/article/2aefe612d931437fb2599f63ef8e7bf0
Autor:
Michael J. Nash, Evgenia Dobrinskikh, Taylor K. Soderborg, Rachel C. Janssen, Diana L. Takahashi, Tyler A. Dean, Oleg Varlamov, Jon D. Hennebold, Maureen Gannon, Kjersti M. Aagaard, Carrie E. McCurdy, Paul Kievit, Bryan C. Bergman, Kenneth L. Jones, Eric M. Pietras, Stephanie R. Wesolowski, Jacob E. Friedman
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112393- (2023)
Summary: Maternal overnutrition increases inflammatory and metabolic disease risk in postnatal offspring. This constitutes a major public health concern due to increasing prevalence of these diseases, yet mechanisms remain unclear. Here, using nonhum
Externí odkaz:
https://doaj.org/article/61f8abfb16c94221819b0fcca9d1aea3
Autor:
Joseph M. Elsakr, Sifang Kathy Zhao, Valerie Ricciardi, Tyler A. Dean, Diana L. Takahashi, Elinor Sullivan, Stephanie R. Wesolowski, Carrie E. McCurdy, Paul Kievit, Jacob E. Friedman, Kjersti M. Aagaard, Digna R. Velez Edwards, Maureen Gannon
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The prevalence of maternal obesity is increasing in the United States. Offspring born to women with obesity or poor glycemic control have greater odds of becoming obese and developing metabolic disease later in life. Our group has utilized a
Externí odkaz:
https://doaj.org/article/aa19a82e9f5149fe9535985f2027cb5b
Autor:
Joseph M. Elsakr, Jennifer C. Dunn, Katherine Tennant, Sifang Kathy Zhao, Karly Kroeten, Raymond C. Pasek, Diana L. Takahashi, Tyler A. Dean, Digna R. Velez Edwards, Carrie E. McCurdy, Kjersti M. Aagaard, Alvin C. Powers, Jacob E. Friedman, Paul Kievit, Maureen Gannon
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 73-82 (2019)
Objective: In humans, offspring of women who are overweight or obese are more likely to develop metabolic disease later in life. Studies in lower animal species reveal that a calorically-dense maternal diet is associated with alterations in islet cel
Externí odkaz:
https://doaj.org/article/59c889a547274a3b82f1ccc31a532c7e
Autor:
Stephanie R. Wesolowski, Christopher M. Mulligan, Rachel C. Janssen, Peter R. Baker, II, Bryan C. Bergman, Angelo D'Alessandro, Travis Nemkov, Kenneth N. Maclean, Hua Jiang, Tyler A. Dean, Diana L. Takahashi, Paul Kievit, Carrie E. McCurdy, Kjersti M. Aagaard, Jacob E. Friedman
Publikováno v:
Molecular Metabolism, Vol 18, Iss , Pp 25-41 (2018)
Objective: Non-alcoholic fatty liver disease (NAFLD) risk begins in utero in offspring of obese mothers. A critical unmet need in this field is to understand the pathways and biomarkers underlying fetal hepatic lipotoxicity and whether maternal dieta
Externí odkaz:
https://doaj.org/article/a28561519af14a2b8a154ec639481f85
Autor:
Sweta Ravisankar, Alison Y. Ting, Melinda J. Murphy, Nash Redmayne, Dorothy Wang, Carrie A. McArthur, Diana L. Takahashi, Paul Kievit, Shawn L. Chavez, Jon D. Hennebold
Publikováno v:
JCI Insight, Vol 6, Iss 4 (2021)
A maternal Western-style diet (WSD) is associated with poor reproductive outcomes, but whether this is from the diet itself or underlying metabolic dysfunction is unknown. Here, we performed a longitudinal study using regularly cycling female rhesus
Externí odkaz:
https://doaj.org/article/9993192950aa49888954abffa4bf04cd
Autor:
Jacqueline R. Thompson, Hanna C. Gustafsson, Madison DeCapo, Diana L. Takahashi, Jennifer L. Bagley, Tyler A. Dean, Paul Kievit, Damien A. Fair, Elinor L. Sullivan
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Nutritional status influences brain health and gestational exposure to metabolic disorders (e.g. obesity and diabetes) increases the risk of neuropsychiatric disorders. The aim of the present study was to further investigate the role of maternal West
Externí odkaz:
https://doaj.org/article/c201bacac4184799a0b5964dcabb30f6
Autor:
Cecily V, Bishop, Diana L, Takahashi, Fangzhou, Luo, Heather, Sidener, Lauren Drew, Martin, Lina, Gao, Suzanne S, Fei, Jon D, Hennebold, Ov D, Slayden
Publikováno v:
Biology of Reproduction. 108:72-80
Polycystic ovary syndrome (PCOS) is associated with irregular menstrual cycles, hyperandrogenemia, and obesity. It is currently accepted that women with PCOS are also at risk for endometriosis, but the effect of androgen and obesity on endometriosis
Autor:
Darian T. Carroll, Joseph M. Elsakr, Allie Miller, Jennifer Fuhr, Sarah R. Lindsley, Melissa Kirigiti, Diana L. Takahashi, Tyler A. Dean, Stephanie R. Wesolowski, Carrie E. McCurdy, Jacob E. Friedman, Kjersti M. Aagaard, Paul Kievit, Maureen Gannon
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism.
Maternal overnutrition is associated with increased susceptibility to Type 2 Diabetes in the offspring. Rodent models have shown that maternal overnutrition influences islet function in offspring. To determine whether maternal Western style diet (WSD
Autor:
Sambit Roy, Aierken Abudu, Irving Salinas, Niharika Sinha, Holly Cline-Fedewa, Alexandra M Yaw, Wenjie Qi, Todd A Lydic, Diana L Takahashi, Jon D Hennebold, Hanne M Hoffmann, Jianrong Wang, Aritro Sen
Publikováno v:
Endocrinology. 163
In women, excess androgen causes polycystic ovary syndrome (PCOS), a common fertility disorder with comorbid metabolic dysfunctions including diabetes, obesity, and nonalcoholic fatty liver disease. Using a PCOS mouse model, this study shows that chr