Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Diana L. Leung"'
Autor:
Alan A. Cohen, Diana L. Leung, Véronique Legault, Dominique Gravel, F. Guillaume Blanchet, Anne-Marie Côté, Tamàs Fülöp, Juhong Lee, Frédérik Dufour, Mingxin Liu, Yuichi Nakazato
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104385- (2022)
Summary: Critical transition theory suggests that complex systems should experience increased temporal variability just before abrupt state changes. We tested this hypothesis in 763 patients on long-term hemodialysis, using 11 biomarkers collected ev
Externí odkaz:
https://doaj.org/article/b457466b897649a18a021aa9043ae202
Autor:
Mingxin Liu, Véronique Legault, Tamàs Fülöp, Anne-Marie Côté, Dominique Gravel, F. Guillaume Blanchet, Diana L. Leung, Sylvia Juhong Lee, Yuichi Nakazato, Alan A. Cohen
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
There is an increasingly widespread use of biomarkers in network physiology to evaluate an organism’s physiological state. A recent study showed that albumin variability increases before death in chronic hemodialysis patients. We hypothesized that
Externí odkaz:
https://doaj.org/article/37b41804b71b4182b57ed8c8185e28de
Autor:
Alan A. Cohen, Diana L. Leung, Véronique Legault, Dominique Gravel, F. Guillaume Blanchet, Anne-Marie C. Côté, Tamàs Fülöp, Juhong Lee, Frédérik Dufour, Mingxin Liu, Yuichi Nakazato
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc9498452caac5f4a4bb753a9ed57689
https://doi.org/10.2139/ssrn.4007577
https://doi.org/10.2139/ssrn.4007577
Autor:
Tamas Fulop, Lee Sj, Mingxin Liu, Diana L Leung, Nakazato Y, Dominique Gravel, Frédérik Dufour, Blanchet Fg, Anne-Marie Côté, Alan A. Cohen, Legault
Critical transition theory suggests that complex systems should experience increased temporal variability just before abrupt change, such as increases in clinical biomarker variability before mortality. We tested this in the context of hemodialysis u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cd3152ca440d9e875ba82b7aa0baac7
https://doi.org/10.1101/2021.05.14.21257235
https://doi.org/10.1101/2021.05.14.21257235
Autor:
Rena Ohno, Diana L Leung, Tomoko Sugiyama, Riichi Kurane, Hiromi Shimoyama, Alan A. Cohen, Akihisa Watanabe, Satoru Hirose, Hirofumi Shimoyama, Yuichi Nakazato
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Increased intraindividual variability in several biological parameters is associated with aspects of frailty and may reflect impaired physiological regulation. As frailty involves a cumulative decline in multiple physiological systems, we aimed to es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73776daeff5bf0ec815de8495c50dddd
https://pubmed.ncbi.nlm.nih.gov/32587279
https://pubmed.ncbi.nlm.nih.gov/32587279
Publikováno v:
Unifying Themes in Complex Systems IX ISBN: 9783319966601
Individual biomarkers are often studied as indicators of abnormality, but a complex systems perspective suggests that further insight may be gained by considering biomarker values in the context of others. The concept of homeostasis implies that norm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf1af1d9596f99eff7c0613351a2384a
https://doi.org/10.1007/978-3-319-96661-8_33
https://doi.org/10.1007/978-3-319-96661-8_33
Autor:
Diana L Leung, Tomoko Sugiyama, Véronique Legault, Alan A. Cohen, Yuichi Nakazato, Anne-Marie Côté
Publikováno v:
Innovation in Aging
Increased variability in levels of several individual biomarkers has been shown to predict adverse outcomes, particularly in hemodialysis patients, for whom time series data is often available. Here, we evaluate the feasibility of using multivariate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9810a111358b7a864e7f849b00214edd
http://europepmc.org/articles/PMC6844849
http://europepmc.org/articles/PMC6844849
Publikováno v:
Innovation in Aging
Investigation into the hallmarks of aging point to the existence of shared mechanisms that underlie the biological aging process. While there is a general consensus that hallmarks of aging rarely occur in isolation, little is known in regards to thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507a6833b94020ce00e21558afedbb2e
https://doi.org/10.1093/geroni/igz038.1584
https://doi.org/10.1093/geroni/igz038.1584