Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Diana L. Donnelly-Roberts"'
Autor:
Yao Liang Wong, Lauren LeBon, Ana M Basso, Kathy L Kohlhaas, Arthur L Nikkel, Holly M Robb, Diana L Donnelly-Roberts, Janani Prakash, Andrew M Swensen, Nimrod D Rubinstein, Swathi Krishnan, Fiona E McAllister, Nicole V Haste, Jonathon J O'Brien, Margaret Roy, Andrea Ireland, Jennifer M Frost, Lei Shi, Stephan Riedmaier, Kathleen Martin, Michael J Dart, Carmela Sidrauski
Publikováno v:
eLife, Vol 8 (2019)
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2
Externí odkaz:
https://doaj.org/article/7ff3f238f99040afb97c2dc3b9419d6e
Autor:
Kathy Sarris, Philip J. Hajduk, Ihle David C, Diana L. Donnelly-Roberts, Arthur Gomtsyan, Christian Goess, David B. Duignan, Danying Song, Chaohong Sun, Andrea Mcclure, Adrian D. Hobson, Robert H. Stoffel, Anil Vasudevan, John A. Mankovich, Sanjay C. Panchal, A. Chris Krueger, Steven L. Swann, Kenneth M. Comess, Andrew M. Petros, Wilson Noel S, Jill M. Wetter, Paul G. Richardson, Kenton L. Longenecker, Paul M. Jung, Vincent S. Stoll, Amanda W. Dombrowski, Suzanne Mathieu, Justin D. Dietrich, Philip B. Cox
Publikováno v:
Journal of Medicinal Chemistry. 64:417-429
Tumor necrosis factor α (TNFα) is a soluble cytokine that is directly involved in systemic inflammation through the regulation of the intracellular NF-κB and MAPK signaling pathways. The development of biologic drugs that inhibit TNFα has led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dbe3ede703ddd1435f27709b6c8281
https://doi.org/10.1021/acs.jmedchem.0c01280
https://doi.org/10.1021/acs.jmedchem.0c01280
Autor:
Arthur L. Nikkel, Marian T. Namovic, D. L. Widomski, Diana L. Donnelly-Roberts, Steve McGaraughty, Zhi Su, Laura Leys, Murali Gopalakrishnan
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 29:281-290
Background:Losartan, a blocker of the angiotensin II type I receptor, is an important part of the standard of care for diabetic nephropathy (DN). The obese ZSF-1 rats display many aspects of the clinical features of human Type II DN. The current stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ee6718b0617d47fc87a9b5095eb0e3
https://doi.org/10.1515/jbcpp-2017-0157
https://doi.org/10.1515/jbcpp-2017-0157
Autor:
Diana L. Donnelly-Roberts, Ana M. Basso, Arthur L. Nikkel, Andrea T. Ireland, Jennifer M. Frost, Lauren LeBon, Carmela Sidrauski, Stephan Riedmaier, Nimrod D. Rubinstein, Holly M. Robb, Kathleen A. Martin, Nicole V Haste, Fiona E. McAllister, Swathi Krishnan, Lei Shi, Margaret Ann Roy, Andrew M. Swensen, Janani Prakash, Jonathon J. O’Brien, Kathy L. Kohlhaas, Yao Liang Wong, Michael J. Dart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ebd2110389786065142053652d6bb1f
https://doi.org/10.7554/elife.42940.036
https://doi.org/10.7554/elife.42940.036
Autor:
Diana L. Donnelly-Roberts, Arthur L. Nikkel, Chang Z. Zhu, Steve McGaraughty, Kelly J. Doyle, Murali Gopalakrishnan, Marian T. Namovic, K. Salte, Lauren Olsen, D. L. Widomski, Zhi Su
Publikováno v:
Journal of pharmacological and toxicological methods. 94(Pt 1)
Introduction The adenine model of kidney disease typically involves dietary delivery of adenine over several weeks. This model can be variable in its disease progression and can result in significant mortality. In the current study, the amount of ade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e16bcc1990a1673c0f52adad06e199e
https://pubmed.ncbi.nlm.nih.gov/29684554
https://pubmed.ncbi.nlm.nih.gov/29684554
Autor:
Ji Ma, Timothy A. Esbenshade, Steve McGaraughty, Arthur L. Nikkel, D. L. Widomski, Marian T. Namovic, K. Salte, Diana L. Donnelly-Roberts, Laura Leys, L. Olson, Zhi Su
Background: Obese ZSF-1 rats display many features of human type II diabetes including nephropathy (DN). The study aimed to further understand the relevance of this model to DN, for which glomerular filtration rate (GFR), renal fibrosis and several u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb2bb568a00fb342d1065eaeb1cf1cb
https://europepmc.org/articles/PMC5389169/
https://europepmc.org/articles/PMC5389169/
Autor:
Andrew O. Stewart, Janel M. Boyce-Rustay, Ivan Milicic, Chang Z. Zhu, Jill M. Wetter, Timothy A. Vortherms, Michael F. Jarvis, Marian T. Namovic, Diana L. Donnelly-Roberts, Chengmin Zhong, Victoria E. Scott, Karen Kage, Rodger F. Henry, Erica Gomez, Scott J. Baker, Carol S. Surowy, Daria Darczak, Pamela H. Franklin, Gricelda H. Simler, Wende Niforatos, Richard S. Janis, Andrew M. Swensen, Kennan C. Marsh, Xenia Beebe
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:4128-4139
A novel 4-aminocyclopentapyrrolidine series of N-type Ca(2+) channel blockers have been discovered. Enantioselective synthesis of the 4-aminocyclopentapyrrolidines was enabled using N-tert-butyl sulfinamide chemistry. SAR studies demonstrate selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::903d471b779294dbab78f23177d949d0
https://doi.org/10.1016/j.bmc.2012.04.057
https://doi.org/10.1016/j.bmc.2012.04.057
Autor:
Sridhar Peddi, Diana L. Donnelly-Roberts, Connie R. Faltynek, Arturo Perez-Medrano, Derek W. Nelson, Tongmei Li, Alan S. Florjancic, William A. Carroll, Michael F. Jarvis, Marian T. Namovic
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3297-3300
Synthesis and biological evaluation of a novel class of substituted N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine derivatives resulted in the identification of potent P2X7 antagonists. These compounds were assayed for activity at both the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683e04fd57c19abe464f0206f2e5483b
https://doi.org/10.1016/j.bmcl.2011.04.024
https://doi.org/10.1016/j.bmcl.2011.04.024
Autor:
James T. Limberis, Di Zhang, Torben R. Neelands, Richard S. Janis, Diana L. Donnelly-Roberts, Wende Niforatos, Timothy A. Vortherms, Carol S. Surowy, C. Brent Putman, Ruth L. Martin, Michael F. Jarvis, Marian T. Namovic, Rama Thimmapaya, Andrew M. Swensen, Victoria E. Scott
Publikováno v:
Inflammation Research. 60:683-693
The aim of this study was to compare a diverse set of peptide and small-molecule calcium channel blockers for inactivated-state block of native and recombinant N-type calcium channels using fluorescence-based and automated patch-clamp electrophysiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a08e3a3b09d01bec446cbdc79a1bd31
https://doi.org/10.1007/s00011-011-0322-9
https://doi.org/10.1007/s00011-011-0322-9
Publikováno v:
British Journal of Pharmacology. 157:1203-1214
Background and purpose: Acute activation of P2X7 receptors rapidly opens a non-selective cation channel. Sustained P2X7 receptor activation leads to the formation of cytolytic pores, mediated by downstream recruitment of hemichannels to the cell surf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b55b643efcd51350eb1eac84bc870a
https://doi.org/10.1111/j.1476-5381.2009.00233.x
https://doi.org/10.1111/j.1476-5381.2009.00233.x