Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Diana L, Williams"'
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
Mycobacterium leprae, the causative agent of leprosy, is an obligate intracellular pathogen primarily residing within host macrophages and Schwann cells. Whole genome sequencing predicts a highly degraded genome with approximately one third of the co
Externí odkaz:
https://doaj.org/article/7c3a718263ed494091aeec13497346a1
Autor:
Khushboo Borah, Jacque-Lucca Kearney, Ruma Banerjee, Pankaj Vats, Huihai Wu, Sonal Dahale, Sunitha Manjari Kasibhatla, Rajendra Joshi, Bhushan Bonde, Olabisi Ojo, Ramanuj Lahiri, Diana L Williams, Johnjoe McFadden
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0007871 (2020)
Leprosy, caused by Mycobacterium leprae, has plagued humanity for thousands of years and continues to cause morbidity, disability and stigmatization in two to three million people today. Although effective treatment is available, the disease incidenc
Externí odkaz:
https://doaj.org/article/194597e791744d9a9caf9e9f4b498baa
Autor:
Dennis J. Montoya, Priscila Andrade, Bruno J.A. Silva, Rosane M.B. Teles, Feiyang Ma, Bryan Bryson, Saheli Sadanand, Teia Noel, Jing Lu, Euzenir Sarno, Kristine B. Arnvig, Douglas Young, Ramanuj Lahiri, Diana L. Williams, Sarah Fortune, Barry R. Bloom, Matteo Pellegrini, Robert L. Modlin
Publikováno v:
Cell Reports, Vol 26, Iss 13, Pp 3574-3585.e3 (2019)
Summary: To understand how the interaction between an intracellular bacterium and the host immune system contributes to outcome at the site of infection, we studied leprosy, a disease that forms a clinical spectrum, in which progressive infection by
Externí odkaz:
https://doaj.org/article/c290baf017d1454685b0caf5a662db37
Autor:
Shannon M. Lenz, Nashone A. Ray, Tsehaynesh Lema, J. Hunter Collins, Ruby Thapa, Selfu Girma, Marivic Balagon, Kidist Bobosha, Deanna A. Hagge, Diana L. Williams, David M. Scollard, Ramanuj Lahiri, Linda B. Adams
Publikováno v:
Frontiers in Tropical Diseases. 3
Mycobacterium leprae is a slow-growing species of mycobacteria that cannot be cultured in axenic media. This presents a number of challenges for monitoring treatment efficacy and advancing new drugs and regimens for treating leprosy. We previously de
Autor:
Diana L. Williams
Publikováno v:
Br J Pharmacol
Glucagon-like peptide 1 (GLP-1) is well known as a gut hormone and also acts as a neuropeptide, produced in a discrete population of caudal brainstem neurons that project widely throughout the brain. GLP-1 receptors are expressed in many brain areas
Autor:
Sergio Araujo, Luiz Ricardo Goulart, Richard W Truman, Isabela Maria B Goulart, Varalakshmi Vissa, Wei Li, Masanori Matsuoka, Philip Suffys, Amanda B Fontes, Patricia S Rosa, David M Scollard, Diana L Williams
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005506 (2017)
BACKGROUND:Real-Time PCR-High Resolution Melting (qPCR-HRM) analysis has been recently described for rapid drug susceptibility testing (DST) of Mycobacterium leprae. The purpose of the current study was to further evaluate the validity, reliability,
Externí odkaz:
https://doaj.org/article/3e0ee1058b354bf29ea7faa8506a93ac
Publikováno v:
Emerging Infectious Diseases, Vol 24, Iss 8, Pp 1584-1585 (2018)
Skin biopsies from US leprosy patients were tested for mutations associated with drug resistance. Dapsone resistance was found in 4 of 6 biopsies from American Samoa patients. No resistance was observed in patients from other origins. The high rate o
Externí odkaz:
https://doaj.org/article/0a3ea6ce4d7846ddb0debf0bb83ac02d
Autor:
Rahul Sharma, Ramanuj Lahiri, David M. Scollard, Maria Pena, Diana L. Williams, Linda B. Adams, John Figarola, Richard W. Truman
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 1, Pp 19-24 (2013)
Leprosy (also known as Hansen’s disease) is an infectious peripheral neurological disorder caused by Mycobacterium leprae that even today leaves millions of individuals worldwide with life-long disabilities. The specific mechanisms by which this ba
Externí odkaz:
https://doaj.org/article/38434564fc1144518a2a84ecd9922453
Autor:
Diana L. Williams
Publikováno v:
In Practice
Background:Fasciola hepatica is a common parasite of grazing livestock, which causes considerable economic losses through high levels of morbidity, mortality and reduced productivity. Its prevalence has increased in recent years, probably due to envi
Publikováno v:
Obesity (Silver Spring)
Objective Intermittent (INT) access to a high-fat diet (HFD) can induce excessive-intake phenotypes in rodents. This study hypothesized that impaired satiation responses contribute to elevated intake in an INT-HFD access model. Methods First, this st