Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Diana Kuehn"'
Publikováno v:
Frontiers in Plant Science, Vol 8 (2017)
Flowering time genes have a strong influence on successful reproduction and life cycle adaptation. However, their regulation is highly complex and only well understood in diploid model systems. For crops with a polyploid background from the genus Bra
Externí odkaz:
https://doaj.org/article/7176928e19ea4dcfaa4171db9ecca6fa
Autor:
Claire Ward, Diana Kuehn, Roberta E Burden, Julie A Gormley, Thomas J Jaquin, Mihaela Gazdoiu, Donna Small, Roy Bicknell, James A Johnston, Christopher J Scott, Shane A Olwill
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12489 (2010)
BACKGROUND: Angiogenesis is a key hallmark of tumourigenesis and its inhibition is a proven strategy for the development of novel anti-cancer therapeutics. An important aspect of early angiogenesis is the co-ordinated migration and invasion of endoth
Externí odkaz:
https://doaj.org/article/3e20d26756f14f4193cfcc32518e6ad2
Autor:
Yang Xiang, Carole Mathis, Diana Kuehn, Emmanuel Guedj, Stefan Frentzel, Julia Hoeng, Patrice Leroy, Nikolai V. Ivanov, Florian Martin, Marja Talikka, Manuel C. Peitsch, Anita R. Iskandar
Publikováno v:
Toxicological Sciences
Organotypic 3D cultures of epithelial cells are grown at the air-liquid interface (ALI) and resemble the in vivo counterparts. Although the complexity of in vivo cellular responses could be better manifested in coculture models in which additional ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503be7810f544830259d9d17b7a50f9e
https://doi.org/10.1093/toxsci/kfv122
https://doi.org/10.1093/toxsci/kfv122
Publikováno v:
Frontiers in Plant Science, Vol 8 (2017)
Frontiers in Plant Science
Frontiers in Plant Science
Flowering time genes have a strong influence on successful reproduction and life cycle adaptation. However, their regulation is highly complex and only well understood in diploid model systems. For crops with a polyploid background from the genus Bra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2bf1377e842156fc31122b04469074
http://journal.frontiersin.org/article/10.3389/fpls.2017.01742/full
http://journal.frontiersin.org/article/10.3389/fpls.2017.01742/full
Publikováno v:
Scientific Reports
Genetic models for polyploid crop adaptation provide important information relevant for future breeding prospects. A well-suited model is Brassica napus, a recent allopolyploid closely related to Arabidopsis thaliana. Flowering time is a major adapta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5b1e28cfcf07db2b096437ab246dad
Autor:
Alain Sewer, Diana Kuehn, Marja Talikka, Carole Mathis, Julia Hoeng, Radina Kostadinova, Shoaib Majeed, Stefan Frentzel, Marcel Geertz, Nikolai V. Ivanov, Walter K. Schlage, Yang Xiang, Anita R. Iskandar, Manuel C. Peitsch
Publikováno v:
Toxicology Mechanisms and Methods
Smoking has been associated with diseases of the lung, pulmonary airways and oral cavity. Cytologic, genomic and transcriptomic changes in oral mucosa correlate with oral pre-neoplasia, cancer and inflammation (e.g. periodontitis). Alteration of smok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150f48cf63c0e6244bcb488e73c0bcfc
https://doi.org/10.3109/15376516.2014.943441
https://doi.org/10.3109/15376516.2014.943441
Autor:
Mihaela Gazdoiu, Thomas Jaquin, Hang Fai Kwok, Christopher J. Scott, Angela McClurg, Shane Olwill, Diana Kuehn, Claire Ward, Roberta E. Burden, Julie Gormley, James A. Johnston
Publikováno v:
Biochimie. 94:487-493
Cathepsin S is a lysosomal cysteine protease implicated in tumourigenesis with key roles in invasion and angiogenesis. We have previously shown that the specific inhibition of Cathepsin S using a monoclonal antibody (Fsn0503) blocks colorectal carcin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb3586dc049c9532cb1be300b0c5c30
https://doi.org/10.1016/j.biochi.2011.08.017
https://doi.org/10.1016/j.biochi.2011.08.017
Autor:
David John Miller, John S. Mills, Diana Kuehn, Matthias W. Büttner, Bin Zhu, L. H. Tam, Philip Avlar BioVentures Mitchell, David Tebbe, Christian Burschka, Helen Rapley, Ian C. Gray, Parameswary A. Muniandy, Reinhold Tacke, Matthew J. Barnes, Jürgen O. Daiss, Alan G. Hendrick, Julie B. H. Warneck, Richard Conroy, Graham A. Showell, John Gary Montana
Publikováno v:
ChemMedChem. 6:2070-2080
AG-045572 (CMPD1, 1 a) is a nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist that has been investigated for the treatment of sex hormone-related diseases. In the context of systematic studies on sila-substituted drugs, the silicon analogu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0906f5604ca83099549d80545ab529
https://doi.org/10.1002/cmdc.201100318
https://doi.org/10.1002/cmdc.201100318
Autor:
Shoaib Majeed, Julia Hoeng, Anita R. Iskandar, Karine Baumer, Carole Mathis, Remi Dulize, Emmanuel Guedj, Stefan Frentzel, Radina Kostadinova, Manuel C. Peitsch, Nikolai V. Ivanov, Florian Martin, Diana Kuehn, Stéphanie Boué
Publikováno v:
Journal of Visualized Experiments : JoVE
Cigarette smoke (CS) has a major impact on lung biology and may result in the development of lung diseases such as chronic obstructive pulmonary disease or lung cancer. To understand the underlying mechanisms of disease development, it would be impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12db04ace9fbf378e21a352129bca056
https://doi.org/10.3791/52325-v
https://doi.org/10.3791/52325-v
Autor:
Manuel C. Peitsch, Arno Knorr, Shoaib Majeed, Diana Kuehn, Julia Hoeng, Philippe A Guy, Sandra Wagner, Patrice Leroy, Stefan Frentzel
Publikováno v:
Chemistry Central Journal
Background Only a few exposure systems are presently available that enable cigarette smoke exposure of living cells at the air–liquid interface, of which one of the most versatile is the Vitrocell® system (Vitrocell® Systems GmbH). To assess its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0185dea309c08b28ad8cb7827776a224
http://europepmc.org/articles/PMC4236458
http://europepmc.org/articles/PMC4236458