Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Diana J. Watt"'
Autor:
Jennifer E. Morgan, Keelin O'Donoghue, Huseyin Mehmet, Jerry Chan, M. Gavina, Diana J. Watt, Nicholas M. Fisk, Yvan Torrente, N Kennea, Helen Stewart
Publikováno v:
STEM CELLS. 24:1879-1891
Cell therapy for degenerative muscle diseases such as the muscular dystrophies requires a source of cells with the capacity to participate in the formation of new muscle fibers. We investigated the myogenic potential of human fetal mesenchymal stem c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa2e0dcdd01015cdbf21bbab2a1b487
https://doi.org/10.1634/stemcells.2005-0564
https://doi.org/10.1634/stemcells.2005-0564
Autor:
E. Kenneth Parkinson, Wilhelmina M.H. Behan, June Munro, Katrina E. Gordon, Karen Steeghs, Hazel Ireland, Diana J. Watt, Vivienne Morrison, Martha Wootton
Publikováno v:
Human Gene Therapy. 14:1473-1487
Continuous cycles of muscle fiber necrosis and regeneration are characteristic of the muscular dystrophies, and in some cases this leads to premature replicative senescence of myoblasts in vitro. The molecular mechanism of senescence in human myoblas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32505b2a796d8deff71cfe43983e7077
https://doi.org/10.1089/104303403769211682
https://doi.org/10.1089/104303403769211682
Publikováno v:
Neuromuscular Disorders. 12:183-186
We have previously shown that galectin-1 is a factor capable of converting mouse dermal fibroblasts to the myogenic lineage [Cell Transplant 2000;9:519]. Here, we report that human dermal fibroblasts are also capable of expressing the myogenic marker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c970a139b35c30e92a968df0a460c351
https://doi.org/10.1016/s0960-8966(01)00280-2
https://doi.org/10.1016/s0960-8966(01)00280-2
Publikováno v:
The Journal of Pathology. 197:457-467
Since its discovery four decades ago, the satellite cell of skeletal muscle has been implicated as the major source of myogenic cells involved in growth and repair of muscle fibres. This review not only looks at the role of the satellite cell in thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7caa76dbad3dc3b0f036d01a45f10e82
https://doi.org/10.1002/path.1157
https://doi.org/10.1002/path.1157
Autor:
Diana J. Watt, Deborah Pye
Publikováno v:
Journal of Anatomy. 198:163-173
Both in vitro and in vivo studies have described the conversion of fibroblasts to myogenesis when in the presence of dysfunctional myogenic cells. Myogenic conversion of fibroblasts subjected to a normal, as opposed to a diseased muscle environment h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbbaddcb0fe81a03123ccf764d044b3
https://doi.org/10.1046/j.1469-7580.2001.19820163.x
https://doi.org/10.1046/j.1469-7580.2001.19820163.x
Publikováno v:
Scopus-Elsevier
Cell Transplantation, Vol 9 (2000)
Cell Transplantation, Vol 9 (2000)
Using the mdx mouse model for human Duchenne muscular dystrophy we have shown that a cell population residing in the dermis of C57B1/10ScSn mouse skin is capable of converting to a myogenic lineage when implanted into the mdx muscle environment. It w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ddc0d7227524d17738855883c6741f
https://doi.org/10.1177/096368970000900408
https://doi.org/10.1177/096368970000900408
Publikováno v:
Journal of Cellular Biochemistry. 61:363-374
The limb and axial skeletal muscles of mammals originate from somitic dermomyotome, which during early development separates to form two discrete structures, the dermatome and the myotome. The latter cell mass gives rise to the muscle-forming lineage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::201c1f5910ea1922097ea777ee4439e4
https://doi.org/10.1002/(sici)1097-4644(19960601)61:3<363::aid-jcb4>3.0.co
https://doi.org/10.1002/(sici)1097-4644(19960601)61:3<363::aid-jcb4>3.0.co
Autor:
Alexander J. Gibson, Diana J. Watt, Tim G. Sherratt, Peter N. Strong, Jill Moss, J Karasinski, João B. Relvas
Publikováno v:
Journal of Cell Science. 108:207-214
Duchenne muscular dystrophy is a primary muscle disease that manifests itself in young boys as a result of a defect in a gene located on the X-chromosome. This gene codes for dystrophin, a normal muscle protein that is located beneath the sarcolemma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9fd637bcc887466503ee790af078eb9
https://doi.org/10.1242/jcs.108.1.207
https://doi.org/10.1242/jcs.108.1.207
Autor:
Diana J Watt, Sid Sidhu, Anthony N. Warrens, Giovanna Lombardi, Robert I. Lechler, Jun Yan Zhang, Caroline A Sewry
Publikováno v:
International Immunology. 6:847-853
Recent interest in myoblast transfer and in the use of myoblasts as vehicles in gene therapy has made it important to understand the potential immunogenicity of allogeneic or neoantigen-expressing myoblasts. Given the problems of producing a pure pop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b919eb28796c0d0467b0febca1f570a
https://doi.org/10.1093/intimm/6.6.847
https://doi.org/10.1093/intimm/6.6.847
Publikováno v:
Journal of Muscle Research and Cell Motility. 14:121-132
C2 mouse myogenic cells carrying the lacZ gene coding for beta-galactosidase (beta-gal) were injected into the tibialis anterior muscle of dystrophin-deficient mdx mice. Introduced cells were shown to have been incorporated into fibres of the injecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6c41b26dd82fbef54319ead432db55
https://doi.org/10.1007/bf00132186
https://doi.org/10.1007/bf00132186