Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Diana J Leeming"'
Autor:
Leona Dold, Mette J Nielsen, Michael Praktiknjo, Carolynne Schwarze-Zander, Christoph Boesecke, Robert Schierwagen, Raphael Mohr, Jan-Christian Wasmuth, Christian Jansen, Jenny Bischoff, Jürgen Kurt Rockstroh, Morten A Karsdal, Ulrich Spengler, Jonel Trebicka, Diana J Leeming
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219526 (2019)
Background and aimsAlthough combined antiretroviral treatment (cART) has improved overall survival of HIV infected patients, liver fibrosis and liver related-mortality still constitute major challenges in HIV positive patients. Collagen accumulates i
Externí odkaz:
https://doaj.org/article/7cc78d0bbe904a69b4b46ab085aa2ed4
Autor:
Anja Schmidt-Christensen, Gustaw Eriksson, William M. Laprade, Behnaz Pirzamanbein, Maria Hörnberg, Kajsa Linde, Julia Nilsson, Mark Skarsfeldt, Diana J. Leeming, Rajmund Mokso, Mariana Verezhak, Anders Dahl, Vedrana Dahl, Kristina Önnerhag, Massoud Rezaee Oghazi, Sofia Mayans, Dan Holmberg
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Metabolic dysfunction-associated steatohepatitis (MASH) is a common but frequently unrecognized complication of obesity and type 2 diabetes. The association between these conditions is multifaceted and involves complex interactions between m
Externí odkaz:
https://doaj.org/article/db9037679b7c45cda4befe58e0d553cb
Autor:
Mette J Nielsen, Konstantin Kazankov, Diana J Leeming, Morten A Karsdal, Aleksander Krag, Francisco Barrera, Duncan McLeod, Jacob George, Henning Grønbæk
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137302 (2015)
Detection of advanced fibrosis (Metavir F≥3) is important to identify patients with a high urgency of antiviral treatments vs. those whose treatment could be deferred (F≤2). The aim was to assess the diagnostic value of novel serological extracel
Externí odkaz:
https://doaj.org/article/d2fb84c40ba2450fa364e875bdf8a38f
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111134 (2014)
ObjectiveCardiovascular diseases are among the most common causes of mortality in renal failure patients undergoing haemodialysis. A high turnover rate of the proteoglycan versican, represented by the increased presence of its fragmentation products
Externí odkaz:
https://doaj.org/article/5570623030694d4bbbec08f8bb321812
Autor:
Christian Jansen, Diana J Leeming, Mattias Mandorfer, Inger Byrjalsen, Robert Schierwagen, Philipp Schwabl, Morten A Karsdal, Evrim Anadol, Christian P Strassburg, Jürgen Rockstroh, Markus Peck-Radosavljevic, Søren Møller, Flemming Bendtsen, Aleksander Krag, Thomas Reiberger, Jonel Trebicka
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108544 (2014)
BackgroundLiver-related deaths represent the leading cause of mortality among patients with HIV/HCV-co-infection, and are mainly related to complications of fibrosis and portal hypertension. In this study, we aimed to evaluate the structural changes
Externí odkaz:
https://doaj.org/article/5ccb18101b9e4197bd1a89a1c67ebc58
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71050 (2013)
ObjectiveThe 7S domain of collagen type IV (P4NP_7S) assessed in plasma represents systemic collagen type IV formation. The objective of the study was to investigate the association of systemic collagen type IV formation with survival among patients
Externí odkaz:
https://doaj.org/article/d070a02f42f74ecfbfd9c8f64a2cb9dd
Autor:
Helene Skjøt-Arkil, Rikke E Clausen, Lars M Rasmussen, Wanchun Wang, Yaguo Wang, Qinlong Zheng, Hans Mickley, Lotte Saaby, Axel C P Diederichsen, Jess Lambrechtsen, Fernando J Martinez, Cory M Hogaboam, Meilan Han, Martin R Larsen, Arkadiusz Nawrocki, Ben Vainer, Dorrit Krustrup, Marina Bjørling-Poulsen, Morten A Karsdal, Diana J Leeming
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e60936 (2013)
Elastin is a signature protein of the arteries and lungs, thus it was hypothesized that elastin is subject to enzymatic degradation during cardiovascular and pulmonary diseases. The aim was to investigate if different fragments of the same protein en
Externí odkaz:
https://doaj.org/article/3013e5bf8cb444a7a63e23b2469f2843
Autor:
Anne C Bay-Jensen, Stephanie Wichuk, Inger Byrjalsen, Diana J Leeming, Nathalie Morency, Claus Christiansen, Morten A Karsdal, Walter P Maksymowych
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54504 (2013)
Inflammation driven connective tissue turnover is key in rheumatic diseases, such as ankylosing spondylitis (AS). Few biomarkers are available for measuring disease prognosis or the efficacy of interventions applied in these tissue-related conditions
Externí odkaz:
https://doaj.org/article/64dda34ff78d40f98825d67c9a3e2d50
Autor:
Elizabeth A. Brown, Anne Minnich, Arun J. Sanyal, Rohit Loomba, Shuyan Du, John Schwarz, Richard L. Ehman, Morten Karsdal, Diana J. Leeming, Giovanni Cizza, Edgar D. Charles
Publikováno v:
JHEP reports : innovation in hepatology, vol 5, iss 4
Background & aimsFALCON 1 was a phase IIb study of pegbelfermin in patients with non-alcoholic steatohepatitis (NASH) and stage 3 fibrosis. This FALCON 1 post hoc analysis aimed to further assess the effect of pegbelfermin on NASH-related biomarkers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387fc65f27fe0d437ddb7fd2988e80a9
https://escholarship.org/uc/item/9b86q751
https://escholarship.org/uc/item/9b86q751
Autor:
Morten Karsdal, Estrid Høgdall, Claus Christiansen, Jesper Skov Neergaard, Katrine Dragsbæk, Diana J. Leeming, Anne-Christine Bay-Jensen, Henrik B. Hansen, Stephanie N. Kehlet, Nicholas Willumsen, Cecilie L. Bager
Supplementary Figure 1. Serum biomarker levels in relation to time to diagnosis. Biomarker levels were plotted against the elapsed time interval between blood draw and cancer diagnosis. The plots were evaluated using a Spearman test.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656334cb2077042a0a3b8a223a9cb251
https://doi.org/10.1158/1055-9965.22437562.v1
https://doi.org/10.1158/1055-9965.22437562.v1