Optimization of Statin-Loaded Delivery Nanoparticles for Treating Chronic Liver Diseases by Targeting Liver Sinusoidal Endothelial Cells

Autor: Mar Gil, Lareen Khouri, Imma Raurell, Diana Rafael, Fernanda Andrade, Ibane Abasolo, Simo Schwartz, María Martínez-Gómez, María Teresa Salcedo, Juan Manuel Pericàs, Diana Hide, Mingxing Wei, Norman Metanis, Joan Genescà, María Martell

Publikováno v: Pharmaceutics, Vol 15, Iss 10, p 2463 (2023)

In this study, we developed functionalized polymeric micelles (FPMs) loaded with simvastatin (FPM-Sim) as a drug delivery system to target liver sinusoidal endothelial cells (LSECs) for preserving liver function in chronic liver disease (CLD). Polyme

Externí odkaz: https://doaj.org/article/e603b3eed6d04f5284bf5147d9e90211

Emricasan Ameliorates Portal Hypertension and Liver Fibrosis in Cirrhotic Rats Through a Hepatocyte‐Mediated Paracrine Mechanism

Autor: Jordi Gracia‐Sancho, Nicolò Manicardi, Martí Ortega‐Ribera, Raquel Maeso‐Díaz, Sergi Guixé‐Muntet, Anabel Fernández‐Iglesias, Diana Hide, Héctor García‐Calderó, Zoe Boyer‐Díaz, Patricia C. Contreras, Alfred Spada, Jaime Bosch

Publikováno v: Hepatology Communications, Vol 3, Iss 7, Pp 987-1000 (2019)

In cirrhosis, liver microvascular dysfunction is a key factor increasing hepatic vascular resistance to portal blood flow, which leads to portal hypertension. De‐regulated inflammatory and pro‐apoptotic processes due to chronic injury play import

Externí odkaz: https://doaj.org/article/5e9aa8e0b22b4f6ab1c1ba7332d46118

Liraglutide improves liver microvascular dysfunction in cirrhosis: Evidence from translational studies

Autor: Fernanda Cristina de Mesquita, Sergi Guixé-Muntet, Anabel Fernández-Iglesias, Raquel Maeso-Díaz, Sergi Vila, Diana Hide, Martí Ortega-Ribera, José Luís Rosa, Juan Carlos García-Pagán, Jaime Bosch, Jarbas Rodrigues de Oliveira, Jordi Gracia-Sancho

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Abstract Hepatic stellate cells (HSC) play a key role in the development of chronic liver disease (CLD). Liraglutide, well-established in type 2 diabetes, showed anti-inflammatory and anti-oxidant properties. We evaluated the effects of liraglutide o

Externí odkaz: https://doaj.org/article/900702cceaa04c7381a0e86421ce63a4

Restoration of liver sinusoidal cell phenotypes by statins improves portal hypertension and histology in rats with NASH

Autor: Joan Genescà, Mar Gil, Anabel Fernández-Iglesias, Miren Bravo, Diana Hide, Aurora Barberá, Salvador Augustin, María Martell, Imma Raurell, María Teresa Salcedo

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Scientific Reports

Non-alcoholic steatohepatitis (NASH) is a common chronic liver disorder in developed countries, with the associated clinical complications driven by portal hypertension (PH). PH may precede fibrosis development, probably due to endothelial dysfunctio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f65bebeb9ca4c892451c0f0c7d060a
http://link.springer.com/article/10.1038/s41598-019-56366-2

Emricasan Ameliorates Portal Hypertension and Liver Fibrosis in Cirrhotic Rats Through a Hepatocyte‐Mediated Paracrine Mechanism

Autor: Diana Hide, Jordi Gracia-Sancho, Zoe Boyer-Diaz, Anabel Fernández-Iglesias, Alfred P. Spada, Raquel Maeso-Díaz, Sergi Guixé-Muntet, Nicolò Manicardi, Patricia C. Contreras, Héctor García-Calderó, Martí Ortega-Ribera, Jaime Bosch

Publikováno v: Hepatology Communications
Hepatology Communications, Vol 3, Iss 7, Pp 987-1000 (2019)
Gracia-Sancho, Jordi; Manicardi, Nicolò; Ortega-Ribera, Martí; Maeso-Díaz, Raquel; Guixé Muntet, Sergi; Fernández-Iglesias, Anabel; Hide, Diana; García-Calderó, Héctor; Boyer-Díaz, Zoe; Contreras, Patricia C; Spada, Alfred; Bosch, Jaime (2019). Emricasan Ameliorates Portal Hypertension and Liver Fibrosis in Cirrhotic Rats Through a Hepatocyte-Mediated Paracrine Mechanism. Hepatology communications, 3(7), pp. 987-1000. 10.1002/hep4.1360

In cirrhosis, liver microvascular dysfunction is a key factor increasing hepatic vascular resistance to portal blood flow, which leads to portal hypertension. De-regulated inflammatory and pro-apoptotic processes due to chronic injury play important

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e156f3537f285d50ae831df9cf59ede9
http://europepmc.org/articles/PMC6601324