Shear- and Compression-induced Chondrocyte Transcription Requires MAPK Activation in Cartilage Explants

Autor: Diana H. Chai, Paul J. Fanning, Jonathan B. Fitzgerald, Moonsoo M. Jin, Alan J. Grodzinsky, Patrick N. Siparsky

Publikováno v: Journal of Biological Chemistry. 283:6735-6743

Chondrocytes regulate the composition of cartilage extracellular matrix in response to mechanical signals, but the intracellular pathways involved in mechanotransduction are still being defined. Mitogen-activated protein kinase (MAPK) pathways are ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7dce251a8770dc1c464981769655c3
https://doi.org/10.1074/jbc.m708670200

Profiles of Basal and Stimulated Receptor Signaling Networks Predict Drug Response in Breast Cancer Lines

Autor: Lili Zhou, Peter K. Sorger, Marc Hafner, Birgit Schoeberl, Diana H. Chai, Emily Pace, Mirra Chung, Mario Niepel

Publikováno v: Science Signaling
Science signaling

Identifying factors responsible for variation in drug response is essential for the effective use of targeted therapeutics. We profiled signaling pathway activity in a collection of breast cancer cell lines before and after stimulation with physiolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acf89952e8275b7a04fe9e00b66c42b
https://doi.org/10.1126/scisignal.2004379

Biomechanical Aspects: Joint Injury and Osteoarthritis

Autor: Anna L. Stevens, Alan J. Grodzinsky, Diana H. Chai

Publikováno v: Topics in Bone Biology ISBN: 9781846285134

Osteoarthritis (OA) is a degenerative joint disease of mechanical wear-and-tear, often localized in weight-bearing joints such as the knees and hips [55]. Age is the most important risk factor for OA, but joint trauma, repetitive joint use, obesity,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7cad5f2412776781cd9326e59c1afa3d
https://doi.org/10.1007/978-1-84628-701-5_10

Substrate specificity of the sialic acid biosynthetic pathway

Autor: Kevin J. Yarema, Christina L. Jacobs, Carolyn R. Bertozzi, Scarlett Goon, Stephan Hinderlich, Diana H. Chai, Howard C. Hang

Publikováno v: Jacobs, Christina L.; Goon, Scarlett; Yarema, Kevin J.; Hinderlich, Stephan; Hang, Howard C.; Chai, Diana H.; et al.(2001). Substrate specificity of the sialic acid biosynthetic pathway. Lawrence Berkeley National Laboratory. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/6dx948b2

Unnatural analogs of sialic acid can be delivered to mammalian cell surfaces through the metabolic transformation of unnatural N-acetylmannosamine (ManNAc) derivatives. In previous studies, mannosamine analogs bearing simple N-acyl groups up to five

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e6e44ccb57e0eb90453ec77051bbba
http://www.escholarship.org/uc/item/6dx948b2

Abstract PR9: Investigating combinatorial ligand addiction provides insights into rational drug combinations in cancer therapy

Autor: Gege Tan, Diana H. Chai, Aaron Fulgham, Raghida Bukhalid, Bryan Johnson, Anand Parikh, Birgit Schoeberl, Shinji Oyama, Emily Pace, Ulrik B. Nielsen, Ashish Kalra

Publikováno v: Cancer Research. 72:PR9-PR9

Cancer, the second most common cause of death in the United States, is a collection of diseases caused by uncontrolled cell growth and metastasis. The main treatment for cancer is chemotherapy, which generally kills fast growing cells nonspecifically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::491d89d10335f5bd07487048af784d5b
https://doi.org/10.1158/1538-7445.csb12-pr9