Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Diana Graus-Porta"'
Autor:
Stephen L. Chan, Martin Schuler, Yoon-Koo Kang, Chia-Jui Yen, Julien Edeline, Su Pin Choo, Chia-Chi Lin, Takuji Okusaka, Karl-Heinz Weiss, Teresa Macarulla, Stéphane Cattan, Jean-Frederic Blanc, Kyung-Hun Lee, Michela Maur, Shubham Pant, Masatoshi Kudo, Eric Assenat, Andrew X. Zhu, Thomas Yau, Ho Yeong Lim, Jordi Bruix, Andreas Geier, Carmen Guillén-Ponce, Angelica Fasolo, Richard S. Finn, Jia Fan, Arndt Vogel, Shukui Qin, Markus Riester, Vasiliki Katsanou, Monica Chaudhari, Tomoyuki Kakizume, Yi Gu, Diana Graus Porta, Andrea Myers, Jean-Pierre Delord
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Abstract Background Deregulation of FGF19-FGFR4 signaling is found in several cancers, including hepatocellular carcinoma (HCC), nominating it for therapeutic targeting. FGF401 is a potent, selective FGFR4 inhibitor with antitumor activity in preclin
Externí odkaz:
https://doaj.org/article/1a80d93b46254b83bfdf5d4c0de1a368
Autor:
Mélanie Wilbaux, Shu Yang, Astrid Jullion, David Demanse, Diana Graus Porta, Andrea Myers, Christophe Meille, Yi Gu
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:1329-1339
Model-informed dose selection has been drawing increasing interest in oncology early clinical development. The current paper describes the example of FGF401, a selective fibroblast growth factor receptor 4 (FGFR4) inhibitor, in which a comprehensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa51648b7bb57396c59e89a3f541768b
https://doi.org/10.1002/cpt.2752
https://doi.org/10.1002/cpt.2752
Autor:
Ralph Tiedt, Alan Buckler, Christopher J. Wilson, Diana Graus-Porta, Vic E. Myer, Jeffrey A. Porter, William R. Sellers, Francesco Hofmann, Peter M. Finan, Thomas Metz, Vito Guagnano, Chris X. Lu, Feng He, Yao Yao, Christian Chatenay-Rivauday, Andreas Buness, Christelle Stamm, Sabrina Wagner, Kelly Ann Sheppard, Lijuan Liu, Douglas Jeffery, Sneha Sanghavi, Vanessa J. Craig, Fred Harbinski
PDF file - 75K, This file contains detailed descriptions of materials and methods that had to be omitted from the main manuscript due to space limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c98b6b1a6e0d1506dc7ac17ab9bf49
https://doi.org/10.1158/2159-8290.22528515.v1
https://doi.org/10.1158/2159-8290.22528515.v1
Autor:
Andrew X. Zhu, Nabeel Bardeesy, Ryan B. Corcoran, Dejan Juric, Alberto Bardelli, Ralph Tiedt, Diana Graus Porta, Gad Getz, A. John Iafrate, James R. Stone, David P. Ryan, Pascal Furet, Christelle Stamm, Louise Barys, Barbara Schacher-Engstler, Sabrina Baltschukat, Joseph M. Gurski, Emily E. Van Seventer, Jiaoyuan Elisabeth Sun, Laura Henderson, Stephanie Reyes, Benedetta Mussolin, Avinash Kambadakone, Vikram Deshpande, Phuong Vu, Jochen K. Lennerz, Leanne G. Ahronian, Ignaty Leshchiner, Giulia Siravegna, Leah Y. Liu, Supriya K. Saha, Lipika Goyal
Complete Data for Genetic Analysis of ctDNA and Tumor Tissue for All Samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259d7240a0c496326f717ca14ca60e36
https://doi.org/10.1158/2159-8290.22531277.v1
https://doi.org/10.1158/2159-8290.22531277.v1
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
Activity of FGF401 in biochemical kinase assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de614aa92fc53e000078388a9034229
https://doi.org/10.1158/1535-7163.22506502.v1
https://doi.org/10.1158/1535-7163.22506502.v1
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
Details on materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855b9cca12680f3ffc27bb3edd85e4d5
https://doi.org/10.1158/1535-7163.22506505.v1
https://doi.org/10.1158/1535-7163.22506505.v1
Autor:
Ralph Tiedt, Alan Buckler, Christopher J. Wilson, Diana Graus-Porta, Vic E. Myer, Jeffrey A. Porter, William R. Sellers, Francesco Hofmann, Peter M. Finan, Thomas Metz, Vito Guagnano, Chris X. Lu, Feng He, Yao Yao, Christian Chatenay-Rivauday, Andreas Buness, Christelle Stamm, Sabrina Wagner, Kelly Ann Sheppard, Lijuan Liu, Douglas Jeffery, Sneha Sanghavi, Vanessa J. Craig, Fred Harbinski
PDF file - 59K, This file contains additional experimental data relating to the profile of JAA120, secretome screening results, gene expression data, and in vivo MET/FGR inhibitor synergy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8822d966da43dd533bf0e796b84a95c8
https://doi.org/10.1158/2159-8290.22528509
https://doi.org/10.1158/2159-8290.22528509
Autor:
Andrew X. Zhu, Nabeel Bardeesy, Ryan B. Corcoran, Dejan Juric, Alberto Bardelli, Ralph Tiedt, Diana Graus Porta, Gad Getz, A. John Iafrate, James R. Stone, David P. Ryan, Pascal Furet, Christelle Stamm, Louise Barys, Barbara Schacher-Engstler, Sabrina Baltschukat, Joseph M. Gurski, Emily E. Van Seventer, Jiaoyuan Elisabeth Sun, Laura Henderson, Stephanie Reyes, Benedetta Mussolin, Avinash Kambadakone, Vikram Deshpande, Phuong Vu, Jochen K. Lennerz, Leanne G. Ahronian, Ignaty Leshchiner, Giulia Siravegna, Leah Y. Liu, Supriya K. Saha, Lipika Goyal
Supplementary Figure S1. Confirmation of secondary point mutation in FGFR2-ZMYM4 allele. Supplementary Figure S2. Homology between FGFR2 and FGFR3 proteins. Supplementary Figure S3. FGFR2-OPTN fusion detected in all autopsy lesions. Supplementary Fig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a948c1840bf99757e3637d1d57bc6518
https://doi.org/10.1158/2159-8290.22531280
https://doi.org/10.1158/2159-8290.22531280
Autor:
Diana Graus-Porta, William R. Sellers, Francesco Hofmann, Carlos Garcia-Echeverria, David M. Thomas, Thomas Brümmendorf, Kavitha Venkatesan, John E. Monahan, Jason Borawski, L. Alex Gaither, Mickaël Le Douget, Vincent Bordas, Christopher J. Wilson, Zhi Chen, Yun Zhang, Fang Li, Yao Yao, Astrid Pornon, Louise Barys, Moriko Ito, Christelle Stamm, Simon Wöhrle, Audrey Kauffmann, Vito Guagnano
PDF file - 1.4MB, Response to NVP-BGJ398; FGFR pathway modulation by NVP-BGJ398; NVP-BGJ398 - predictive features; FGFR2-c3 mRNA expression in cell lines and FGFR2 DNA copy number in tumors; FGF19 DNA copy number in CCLE cell lines and FGFR3 DNA copy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055d71ccbe50a65e308a5319a0af558a
https://doi.org/10.1158/2159-8290.22529469
https://doi.org/10.1158/2159-8290.22529469
Autor:
Ralph Tiedt, Alan Buckler, Christopher J. Wilson, Diana Graus-Porta, Vic E. Myer, Jeffrey A. Porter, William R. Sellers, Francesco Hofmann, Peter M. Finan, Thomas Metz, Vito Guagnano, Chris X. Lu, Feng He, Yao Yao, Christian Chatenay-Rivauday, Andreas Buness, Christelle Stamm, Sabrina Wagner, Kelly Ann Sheppard, Lijuan Liu, Douglas Jeffery, Sneha Sanghavi, Vanessa J. Craig, Fred Harbinski
PDF file - 310K, This file contains additional experimental data relating to ligand-mediated rescue and drug combinations in cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6056ab23a9ee72d9ae3c3a8094ae846e
https://doi.org/10.1158/2159-8290.22528518
https://doi.org/10.1158/2159-8290.22528518