Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Diana Graus Porta"'
Autor:
Stephen L. Chan, Martin Schuler, Yoon-Koo Kang, Chia-Jui Yen, Julien Edeline, Su Pin Choo, Chia-Chi Lin, Takuji Okusaka, Karl-Heinz Weiss, Teresa Macarulla, Stéphane Cattan, Jean-Frederic Blanc, Kyung-Hun Lee, Michela Maur, Shubham Pant, Masatoshi Kudo, Eric Assenat, Andrew X. Zhu, Thomas Yau, Ho Yeong Lim, Jordi Bruix, Andreas Geier, Carmen Guillén-Ponce, Angelica Fasolo, Richard S. Finn, Jia Fan, Arndt Vogel, Shukui Qin, Markus Riester, Vasiliki Katsanou, Monica Chaudhari, Tomoyuki Kakizume, Yi Gu, Diana Graus Porta, Andrea Myers, Jean-Pierre Delord
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Abstract Background Deregulation of FGF19-FGFR4 signaling is found in several cancers, including hepatocellular carcinoma (HCC), nominating it for therapeutic targeting. FGF401 is a potent, selective FGFR4 inhibitor with antitumor activity in preclin
Externí odkaz:
https://doaj.org/article/1a80d93b46254b83bfdf5d4c0de1a368
Autor:
Sébastien Jeay, Swann Gaulis, Stéphane Ferretti, Hans Bitter, Moriko Ito, Thérèse Valat, Masato Murakami, Stephan Ruetz, Daniel A Guthy, Caroline Rynn, Michael R Jensen, Marion Wiesmann, Joerg Kallen, Pascal Furet, François Gessier, Philipp Holzer, Keiichi Masuya, Jens Würthner, Ensar Halilovic, Francesco Hofmann, William R Sellers, Diana Graus Porta
Publikováno v:
eLife, Vol 5 (2016)
Externí odkaz:
https://doaj.org/article/29da49791cad4fb8895cef0bf7f76fea
Autor:
Sébastien Jeay, Swann Gaulis, Stéphane Ferretti, Hans Bitter, Moriko Ito, Thérèse Valat, Masato Murakami, Stephan Ruetz, Daniel A Guthy, Caroline Rynn, Michael R Jensen, Marion Wiesmann, Joerg Kallen, Pascal Furet, François Gessier, Philipp Holzer, Keiichi Masuya, Jens Würthner, Ensar Halilovic, Francesco Hofmann, William R Sellers, Diana Graus Porta
Publikováno v:
eLife, Vol 4 (2015)
Biomarkers for patient selection are essential for the successful and rapid development of emerging targeted anti-cancer therapeutics. In this study, we report the discovery of a novel patient selection strategy for the p53–HDM2 inhibitor NVP-CGM09
Externí odkaz:
https://doaj.org/article/c47da66860c643148939459e36ed4a7e
Autor:
Simon Wöhrle, Andreas Weiss, Moriko Ito, Audrey Kauffmann, Masato Murakami, Zainab Jagani, Anne Thuery, Beatrice Bauer-Probst, Flavia Reimann, Christelle Stamm, Astrid Pornon, Vincent Romanet, Vito Guagnano, Thomas Brümmendorf, William R Sellers, Francesco Hofmann, Charles W M Roberts, Diana Graus Porta
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77652 (2013)
Malignant rhabdoid tumors (MRTs) are aggressive pediatric cancers arising in brain, kidney and soft tissues, which are characterized by loss of the tumor suppressor SNF5/SMARCB1. MRTs are poorly responsive to chemotherapy and thus a high unmet clinic
Externí odkaz:
https://doaj.org/article/5ddabf7e37d840fe9ce647ad449900b5
Autor:
Sungeun Kim, Anna Dubrovska, Richard J Salamone, John R Walker, Kathryn B Grandinetti, Ghislain M C Bonamy, Anthony P Orth, Jimmy Elliott, Diana Graus Porta, Carlos Garcia-Echeverria, Venkateshwar A Reddy
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e51671 (2013)
Emerging evidence suggests that some cancers contain a population of stem-like TICs (tumor-initiating cells) and eliminating TICs may offer a new strategy to develop successful anti-cancer therapies. As molecular mechanisms underlying the maintenance
Externí odkaz:
https://doaj.org/article/afc46a5f03ad4a36ab847a73399cac56
Autor:
Mélanie Wilbaux, Shu Yang, Astrid Jullion, David Demanse, Diana Graus Porta, Andrea Myers, Christophe Meille, Yi Gu
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:1329-1339
Model-informed dose selection has been drawing increasing interest in oncology early clinical development. The current paper describes the example of FGF401, a selective fibroblast growth factor receptor 4 (FGFR4) inhibitor, in which a comprehensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa51648b7bb57396c59e89a3f541768b
https://doi.org/10.1002/cpt.2752
https://doi.org/10.1002/cpt.2752
Autor:
Ralph Tiedt, Alan Buckler, Christopher J. Wilson, Diana Graus-Porta, Vic E. Myer, Jeffrey A. Porter, William R. Sellers, Francesco Hofmann, Peter M. Finan, Thomas Metz, Vito Guagnano, Chris X. Lu, Feng He, Yao Yao, Christian Chatenay-Rivauday, Andreas Buness, Christelle Stamm, Sabrina Wagner, Kelly Ann Sheppard, Lijuan Liu, Douglas Jeffery, Sneha Sanghavi, Vanessa J. Craig, Fred Harbinski
PDF file - 75K, This file contains detailed descriptions of materials and methods that had to be omitted from the main manuscript due to space limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c98b6b1a6e0d1506dc7ac17ab9bf49
https://doi.org/10.1158/2159-8290.22528515.v1
https://doi.org/10.1158/2159-8290.22528515.v1
Autor:
Andrew X. Zhu, Nabeel Bardeesy, Ryan B. Corcoran, Dejan Juric, Alberto Bardelli, Ralph Tiedt, Diana Graus Porta, Gad Getz, A. John Iafrate, James R. Stone, David P. Ryan, Pascal Furet, Christelle Stamm, Louise Barys, Barbara Schacher-Engstler, Sabrina Baltschukat, Joseph M. Gurski, Emily E. Van Seventer, Jiaoyuan Elisabeth Sun, Laura Henderson, Stephanie Reyes, Benedetta Mussolin, Avinash Kambadakone, Vikram Deshpande, Phuong Vu, Jochen K. Lennerz, Leanne G. Ahronian, Ignaty Leshchiner, Giulia Siravegna, Leah Y. Liu, Supriya K. Saha, Lipika Goyal
Complete Data for Genetic Analysis of ctDNA and Tumor Tissue for All Samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259d7240a0c496326f717ca14ca60e36
https://doi.org/10.1158/2159-8290.22531277.v1
https://doi.org/10.1158/2159-8290.22531277.v1
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
Activity of FGF401 in biochemical kinase assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de614aa92fc53e000078388a9034229
https://doi.org/10.1158/1535-7163.22506502.v1
https://doi.org/10.1158/1535-7163.22506502.v1
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
Details on materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855b9cca12680f3ffc27bb3edd85e4d5
https://doi.org/10.1158/1535-7163.22506505.v1
https://doi.org/10.1158/1535-7163.22506505.v1