Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Diana Gikunju"'
Autor:
Diana Gikunju, John W. Cuozzo, Yelena A Arnautova, Sarah A Talcott, Neil Westlund, Andrew J. McRiner, Anthony D. Keefe, Yan Yu, Christelle Huguet, Moritz von Rechenberg, Fei Zhou, Jennifer M Duffy, Shilpi Arora, Esther C.Y. Lee, Ying Zhang, Benjamin Levin, Matthew A. Clark, Jeremy S. Disch, Junyi Zhang, Yanbin Liu, Anton Kozhushnyan, Betty Chan, Anthony C Lau, Michael I Monteiro, Patrick B. Mullins, Anna Kohlmann
Publikováno v:
Journal of Medicinal Chemistry. 64:5049-5066
Bispecific degraders (PROTACs) of ERα are expected to be advantageous over current inhibitors of ERα signaling (aromatase inhibitors/SERMs/SERDs) used to treat ER+ breast cancer. Information from DNA-encoded chemical library (DECL) screening provid
Autor:
Anthony D. Keefe, Jeremy S. Disch, Jennifer Duffy, Esther C. Lee, Diana Gikunju, Betty Chan, Benjamin D. Levin, Michael I. Monteiro, Sarah A. Talcott, Anthony Lau, Fei Zhou, Anton Kozhushnyan, Neil E. Westlund, Patrick B. Mullins, Yan Yu, Moritz von Rechenberg, Junyi Zhang, Yelena Arnautova, Yanbin Liu, Ying Zhang, Andrew J. McRiner, Anna Kohlmann, Matthew A. Clark, John W. Cuozzo, Christelle Huguet, Shilpi Arora
Publikováno v:
Cancer Research. 83:5346-5346
Bispecific degraders (PROTACs) of ERα are expected to be advantageous over current inhibitors of ERα signaling (aromatase inhibitors/SERMs/SERDs) used to treat ER+ breast cancer. Information from DNA-encoded chemical library screening provides a me
Autor:
Ross Overman, Juli Warwicker, Kristin Goldberg, Alexander Pflug, Jeremy S. Disch, Allison Olszewski, Philip B. Rawlins, John P. Guilinger, William McCoull, Rachael Jetson, Anthony D. Keefe, Simon A. Woodcock, Emma Rivers, Olga Collingwood, Elizabeth Hardaker, Sana Bazzaz, Elizabeth Underwood, Marianne Schimpl, J. Willem M. Nissink, Lindsay McMurray, Carolyn Blackett, Diana Gikunju, Jon Winter-Holt, Edward J. Hennessy, Paul D. Smith, Marian Preston, Caroline Truman, Matthew A. Clark, Ying Zhang
Publikováno v:
Journal of medicinal chemistry. 64(6)
Mer is a member of the TAM (Tyro3, Axl, Mer) kinase family that has been associated with cancer progression, metastasis, and drug resistance. Their essential function in immune homeostasis has prompted an interest in their role as modulators of antit
Autor:
Xia Tian, Patrick Riley, Diana Gikunju, Ying Zhang, Christopher D. Hupp, Ling Xue, Matthew A. Clark, Betty Chan, Steven Kearnes, Christelle Huguet, Anthony D. Keefe, Dennis Joseph Moccia, John P. Guilinger, Marie-Aude Guié, Christopher James Mulhern, Kevin McCloskey, John W. Cuozzo, Sana Bazzaz, Eric A. Sigel
Publikováno v:
Journal of medicinal chemistry. 63(16)
DNA-encoded small molecule libraries (DELs) have enabled discovery of novel inhibitors for many distinct protein targets of therapeutic value through screening of libraries with up to billions of unique small molecules. We demonstrate a new approach
Autor:
Holly H. Soutter, Matthew A. Clark, Sevan Habeshian, Eric A. Sigel, Paolo A. Centrella, Diana Gikunju, Christopher D. Hupp, John W. Cuozzo, Anthony D. Keefe, Ying Zhang, Heather A. Thomson
Publikováno v:
ChemBioChem. 18:864-871
We have identified and characterized novel potent inhibitors of Bruton's tyrosine kinase (BTK) from a single DNA-encoded library of over 110 million compounds by using multiple parallel selection conditions, including variation in target concentratio
Autor:
Andrew D. Ferguson, Usha Narayanan, Christelle Huguet, John P Giulinger, Michael I Monteiro, Matthew A. Clark, Chris Hupp, Mortiz Von Rechenberg, Andrew J. McRiner, Kyle Denton, Anthony D. Keefe, John W. Cuozzo, Shilpi Arora, Sarah A Talcott, Diana Gikunju
Publikováno v:
Molecular Cancer Therapeutics. 18:C049-C049
K-Ras is the most frequently mutated oncogene in cancer. Most mutations cluster in codons 12, 13 and 61, and are involved in the development and progression of a wide range of cancers. Drugging K-Ras has been challenging using traditional drug discov
Autor:
John W. Cuozzo, Paolo A. Centrella, Diana Gikunju, Sevan Habeshian, Christopher D. Hupp, Anthony D. Keefe, Eric A. Sigel, Holly H. Soutter, Heather A. Thomson, Ying Zhang, Matthew A. Clark
Publikováno v:
Chembiochem : a European journal of chemical biology. 18(24)
Autor:
Lynette A. Fouser, Yanbin Liu, Junyi Zhang, Diana Gikunju, Jannik N. Andersen, Zooey Wang, Heather A. Thomson, Michael Briskin, Anthony D. Keefe, Dawn M. Troast, Ragunath Chandran, Christopher D. Hupp, Neil Westlund, Moritz von Rechenberg, Ying Zhang, Daniel I. Resnicow, Andrew J. McRiner, Kaan Certel, Julie Liu, Allison Olszewski, Xiaotian Zhu, Michael I Monteiro, Betty Chan, Fei Zhou, John W. Cuozzo, Diala Ezzeddine, Matthew A. Clark
Publikováno v:
Cancer Research. 79:4453-4453
Tumors utilize many different escape mechanisms to evade anti-tumor immune responses. Xios Therapeutics has screened X-Chem’s proprietary 200-billion molecule DNA-encoded library against several immuno-oncology (IO) targets addressing T-cell centri
Autor:
Romesh R. Subramanian, David J. Lamb, Sterghios Moschos, Houria Mechiche, Bruce M. Taylor, Steve Evans, Chris Lapthorn, Michael Yeadon, Kevin Brady, Luis Perez-Tosar, Marion Jurk, Manfred Frick, Sally A. Fancy, Eugen Uhlmann, David Collins, Ovadia Lazari, Lyn H. Jones, Karen G. Spink, Thomas Dino Rockel, Sarah Kearney, Paul Turnpenny, Martin X. Green, Helen Graves, Joerg Vollmer, Gareth Jones, Markus Weber, Matthew D. Selby, Giuseppe Ciaramella, Diana Gikunju
Publikováno v:
Molecular Therapy
Antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) promise specific correction of disease-causing gene expression. Therapeutic implementation, however, has been forestalled by poor delivery to the appropriate tissue, cell type, and s
Autor:
Sevan Habeshian, Ying Zhang, Matthew A. Clark, John W. Cuozzo, Eric A. Sigel, Paolo A. Centrella, Anthony D. Keefe, Diana Gikunju, Christoph E. Dumelin, Marie-Aude Guié, Alexander Litovchick
Publikováno v:
Scientific Reports
A chemical ligation method for construction of DNA-encoded small-molecule libraries has been developed. Taking advantage of the ability of the Klenow fragment of DNA polymerase to accept templates with triazole linkages in place of phosphodiesters, w