Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Diana G. Myles"'
Autor:
Diana G. Myles, Jimin Pei, William J. Snell, Diego A. Ellerman, Paul Primakoff, Surabhi Gupta
Publikováno v:
Molecular Reproduction and Development. 76:1188-1199
Izumo, a sperm membrane protein, is essential for gamete fusion in the mouse. It has an Immunoglobulin (Ig) domain and an N-terminal domain for which neither the functions nor homologous sequences are known. In the present work we identified three no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a433087cbaefe5cd97b3c7d7b3201c73
https://doi.org/10.1002/mrd.21092
https://doi.org/10.1002/mrd.21092
Publikováno v:
Molecular Reproduction and Development. 76:629-636
CD9, a member of the tetraspanin family, associates with a variety of other proteins to form the tetraspanin web. CD9 forms direct and relatively stable associations with the immunoglobulin superfamily proteins EWI-2 and EWI-F. Deletion of the Cd9 ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ad6170e02810e5ccc73a35dcf2950bc
https://doi.org/10.1002/mrd.20991
https://doi.org/10.1002/mrd.20991
Autor:
Diana G. Myles, Paul Primakoff, Kent L. McDonald, Henning Stahlberg, Surabhi Gupta, Zhi Yong He, James E. Evans, Kathryn E. Runge
Publikováno v:
Developmental Biology. 304(1):317-325
Microvilli are found on the surface of many cell types, including the mammalian oocyte, where they are thought to act in initial contact of sperm and oocyte plasma membranes. CD9 is currently the only oocyte protein known to be required for sperm-ooc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d859386b8a928ae4a5963bb98950f0
Publikováno v:
Developmental Cell. 10:831-837
SummaryIn mammals, sperm-egg interaction is based on molecular events either unique to gametes or also present in somatic cells. In gamete fusion, it is unknown which features are gamete specific and which are shared with other systems. Conformationa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300d0c676aab706cdc463cb52a8d80b6
https://doi.org/10.1016/j.devcel.2006.03.011
https://doi.org/10.1016/j.devcel.2006.03.011
Publikováno v:
PROTEOMICS. 6:3533-3543
The sperm interacts with three oocyte-associated structures during fertilization: the cumulus cell layer surrounding the oocyte, the egg extracellular matrix (the zona pellucida), and the oocyte plasma membrane. Each of these interactions is mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e25a550a272cc35e16100cafc30697
https://doi.org/10.1002/pmic.200500845
https://doi.org/10.1002/pmic.200500845
Publikováno v:
Biology of Reproduction. 73:1032-1038
Adam2-null and Adam3-null male mice exhibit reduced levels of one or more ADAM proteins on mature sperm, in addition to the loss of the genetically targeted protein. ADAM protein loss was believed to occur posttranslationally, although the timing of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b56b3237d4a8dd92e1d9a62853de564c
https://doi.org/10.1095/biolreprod.105.040972
https://doi.org/10.1095/biolreprod.105.040972
Publikováno v:
Molecular Biology of the Cell. 14:5098-5103
The function currently attributed to tetraspanins is to organize molecular complexes in the plasma membrane by using multiple cis-interactions. Additionally, the tetraspanin CD9 may be a receptor that binds the soluble ligand PSG17, a member of the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34abeda9f313378d99740f140d1fa10e
https://doi.org/10.1091/mbc.e03-04-0244
https://doi.org/10.1091/mbc.e03-04-0244
Autor:
Diana G. Myles, Gen Kondoh, Junji Takeda, Jennifer A. Alfieri, Arlan D. Martin, Paul Primakoff
Publikováno v:
Journal of Cell Science. 116:2149-2155
Glycosylphosphatidylinositol-anchored proteins on the egg surface have been proposed to play a role in gamete fusion on the basis of in vitro experiments. We tested this hypothesis by asking if oocyte GPI-anchored proteins are required for fertilizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522a23eda340b96fa60d72ae66429268
https://doi.org/10.1242/jcs.00430
https://doi.org/10.1242/jcs.00430
Autor:
Diana G. Myles, Reinhard Fässler, Zhi Yong He, Jordan A. Kreidberg, Cord Brakebusch, Paul Primakoff
Publikováno v:
University of Copenhagen
Antibody inhibition and alpha6beta1 ligand binding experiments indicate that the egg integrin alpha6beta1 functions as a receptor for sperm during gamete fusion; yet, eggs null for the alpha6 integrin exhibit normal fertilization. Alternative integri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8fd40bfeb68b993de8b4ebff0dcce2
https://doi.org/10.1016/s0012-1606(02)00043-x
https://doi.org/10.1016/s0012-1606(02)00043-x
Publikováno v:
Biology of Reproduction. 68:1-9
Fertilization in mammals requires the successful completion of many steps, starting with the transport of gametes in the reproductive tract and ending with sperm-egg membrane fusion. In this minireview, we focus on three adhesion steps in this multis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d579cffe2676c49b4eb67e2627ee41f
https://doi.org/10.1095/biolreprod.102.007856
https://doi.org/10.1095/biolreprod.102.007856