Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Diana G. Eng"'
Autor:
Jeffrey W. Pippin, Natalya Kaverina, Yuliang Wang, Diana G. Eng, Yuting Zeng, Uyen Tran, Carol J. Loretz, Anthony Chang, Shreeram Akilesh, Chetan Poudel, Hannah S. Perry, Christopher O’Connor, Joshua C. Vaughan, Markus Bitzer, Oliver Wessely, Stuart J. Shankland
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 16 (2022)
With an aging population, kidney health becomes an important medical and socioeconomic factor. Kidney aging mechanisms are not well understood. We previously showed that podocytes isolated from aged mice exhibit increased expression of programmed cel
Externí odkaz:
https://doaj.org/article/6f35f7a0c54e416aa558e94eded1b8d9
Publikováno v:
Physiological Reports, Vol 8, Iss 15, Pp n/a-n/a (2020)
Abstract Loss and dysfunction of glomerular podocytes result in increased macromolecule permeability through the glomerular filtration barrier and nephrotic syndrome. Current therapies can induce and maintain disease remission, but cause serious and
Externí odkaz:
https://doaj.org/article/d8f9b678cb6948959555747bc194b7f9
Publikováno v:
Physiological Reports, Vol 8, Iss 12, Pp n/a-n/a (2020)
Abstract CD44 contributes to the activation of glomerular parietal epithelial cells (PECs). Although CD44 expression is higher in PECs of healthy aged mice, the biological role of CD44 in PECs in this context remains unclear. Accordingly, young (4 mo
Externí odkaz:
https://doaj.org/article/3a509e881bd24b8da30aae102381ef9f
Autor:
Natalya V. Kaverina, Diana G. Eng, Andrea D. Largent, Ilse Daehn, Anthony Chang, Kenneth W. Gross, Jeffrey W. Pippin, Peter Hohenstein, Stuart J. Shankland
Publikováno v:
Stem Cell Reports, Vol 9, Iss 4, Pp 1152-1166 (2017)
Wilms' tumor suppressor 1 (WT1) plays an important role in cell proliferation and mesenchymal-epithelial balance in normal development and disease. Here, we show that following podocyte depletion in three experimental models, and in patients with foc
Externí odkaz:
https://doaj.org/article/baa074c6b6234a0c8dc9b18339e657b9
Autor:
Abbal Koirala, Natalya V. Kaverina, Jeffrey W. Pippin, Shreeram Akilesh, Diana G. Eng, Carol Loretz, Yuliang Wang, Stuart J. Shankland
Publikováno v:
Kidney Int
Glomerular podocytes undergo structural and functional changes with advanced age, that increase susceptibility of aging kidneys to worse outcomes following superimposed glomerular diseases. To delineate transcriptional changes in podocytes in aged mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db59d07c1a5a4517a5bf2d67a7252c4
https://doi.org/10.1016/j.kint.2020.05.052
https://doi.org/10.1016/j.kint.2020.05.052
Publikováno v:
Aging. 12:17601-17624
Healthy aging is typified by a progressive and absolute loss of podocytes over the lifespan of animals and humans. To test the hypothesis that a subset of glomerular parietal epithelial cell (PEC) progenitors transition to a podocyte fate with aging,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0846a37f99d191fea59ea8ec5654b05
https://doi.org/10.18632/aging.103788
https://doi.org/10.18632/aging.103788
Autor:
Diana G. Eng, Charles E. Alpers, Gek Cher Chan, Jeffrey W. Pippin, Kelly L. Hudkins, Jeffrey H. Miner, Stuart J. Shankland, Anthony Chang
Publikováno v:
Am J Physiol Renal Physiol
In healthy glomeruli, parietal epithelial cell (PEC)-derived extracellular matrix (ECM) proteins include laminin-β1, perlecan, and collagen type IV-α2 and podocyte-specific ECM proteins include laminin-β2, agrin, and collagen type IV-α4. This stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928f61482a0fdacf86cf954e9002b835
https://doi.org/10.1152/ajprenal.00266.2019
https://doi.org/10.1152/ajprenal.00266.2019
Autor:
Diana G. Eng, Markus Bitzer, Natalya V. Kaverina, Carol Loretz, Oliver Wessely, Yuliang Wang, Yuting Zeng, Christopher L. O’Connor, Uyen Tran, Anthony Chang, Stuart J. Shankland, Jeffrey W. Pippin
Kidney aging and its contribution to disease and its underlying mechanisms are not well understood. With an aging population, kidney health becomes an important medical and socioeconomic factor. We previously showed that podocytes isolated from aged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5db5ccf04a7b46fbdce06630e99a589
https://doi.org/10.1101/2021.10.26.466006
https://doi.org/10.1101/2021.10.26.466006
Autor:
Natalya V. Kaverina, Diana G. Eng, Tyler J. Chozinski, Benjamin S. Freedman, Jeffrey H. Miner, Jeffrey W. Pippin, J. Nathan Kutz, Stuart J. Shankland, Joshua C. Vaughan
Publikováno v:
Kidney International. 96:597-611
Podocytes are differentiated post-mitotic cells that cannot replace themselves after injury. Glomerular parietal epithelial cells are proposed to be podocyte progenitors. To test whether a subset of parietal epithelial cells transdifferentiate to a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89ccdc9af0b3f5cd31c12037ab400c9
https://doi.org/10.1016/j.kint.2019.03.014
https://doi.org/10.1016/j.kint.2019.03.014
Publikováno v:
Physiological Reports, Vol 8, Iss 15, Pp n/a-n/a (2020)
Physiological Reports
Physiological Reports
Loss and dysfunction of glomerular podocytes result in increased macromolecule permeability through the glomerular filtration barrier and nephrotic syndrome. Current therapies can induce and maintain disease remission, but cause serious and chronic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55173cf64cd238a114d953fab2917d1
https://doaj.org/article/d8f9b678cb6948959555747bc194b7f9
https://doaj.org/article/d8f9b678cb6948959555747bc194b7f9