Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Diana Frechilla"'
Autor:
Ana-María Simón, Lucio Schiapparelli, Pablo Salazar-Colocho, Mar Cuadrado-Tejedor, Luis Escribano, Rakel López de Maturana, Joaquín Del Río, Alberto Pérez-Mediavilla, Diana Frechilla
Publikováno v:
Neurobiology of Disease, Vol 33, Iss 3, Pp 369-378 (2009)
Transgenic mice expressing mutant human amyloid precursor protein (APP) develop an age-dependent amyloid pathology and memory deficits, but no overt neuronal loss. Here, in mice overexpressing wild-type human APP (hAPPwt) we found an early memory imp
Externí odkaz:
https://doaj.org/article/2e461231a05a42ae8713ea75cd4c5255
Autor:
Elisa Martín-Montañez, Alberto Pérez-Mediavilla, Mark G. Baxter, Zafar U. Khan, Ana-María Simón, Manuel F. López-Aranda, Irene Navarro-Lobato, Mariam Masmudi-Martín, Diana Frechilla, Inmaculada Jiménez-Recuerda, Juan F. López-Téllez, Philip G. F. Browning
Publikováno v:
Neuroscience. 448:287-298
The integrity of the perirhinal cortex (PRh) is essential for object recognition memory (ORM) function, and damage to this brain area in animals and humans induces irreversible ORM deficits. Here, we show that activation of area V2, a brain area inte
Autor:
Ana Ricobaraza, Diana Frechilla, Rafael Franco, Alberto Pérez-Mediavilla, Mar Cuadrado-Tejedor, Joaquín Del Río, Ana Garcia-Osta
Publikováno v:
Behavioural Brain Research. 220:338-343
This study was undertaken to know whether cognition deficits produced by chronic mild stress (CMS) were associated with pathological markers of Alzheimer's disease (AD). The results show that the impairment in the Morris water maze test induced by CM
Autor:
Lucio Schiapparelli, Joaquín Del Río, Rakel López de Maturana, Ana-María Simón, Luis Escribano, Diana Frechilla, Alberto Pérez-Mediavilla, Pablo Salazar-Colocho, Mar Cuadrado-Tejedor
Publikováno v:
Neurobiology of Disease, Vol 33, Iss 3, Pp 369-378 (2009)
Transgenic mice expressing mutant human amyloid precursor protein (APP) develop an age-dependent amyloid pathology and memory deficits, but no overt neuronal loss. Here, in mice overexpressing wild-type human APP (hAPP(wt)) we found an early memory i
Autor:
Joaquín Del Río, Diana Frechilla, Ana-María Simón, Luis Escribano, Pablo Salazar-Colocho, Alberto Pérez-Mediavilla
Publikováno v:
Biochemical and Biophysical Research Communications. 379:406-410
Clinical trials with rosiglitazone, a potent agonist at peroxisome proliferator-activated receptor gamma (PPARgamma) suggest an improvement of cognitive function in Alzheimer's disease (AD) patients. The mechanisms mediating this potential beneficial
Publikováno v:
Journal of Neurochemistry. 74:1790-1797
The aim of this study was to investigate if p-chloroamphetamine (PCA), which is neurotoxic to serotonin (5-HT) nerve terminals, was able to induce, like 3,4-methylenedioxymethamphetamine, a region-specific regulation of 5-HT1A receptor mRNA expressio
Publikováno v:
International Journal of Developmental Neuroscience. 26:541-550
The involvement of vascular wall in response to neuronal death was challenged here using a transient forebrain ischemia model in gerbil, which causes CA1 neuronal death and trigger neurogenesis in hippocampus. We found an important vascular reaction
Publikováno v:
Biochemical and Biophysical Research Communications. 353:750-755
Recent data suggest that the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor subtype plays a pivotal role in the pathogenesis of effective disorders and in the action of antidepressant drugs. After chronic treatment wi
Publikováno v:
Neuropharmacology. 50:897-907
It has been suggested that antagonists at serotonin 5-HT1A receptors may exert a procognitive effect by facilitating glutamatergic neurotransmission. Here we further explored this issue by looking for the ability of a 5-HT1A antagonist to prevent the
Autor:
M. Teresa García-López, Marta Gutiérrez-Rodríguez, Diana Frechilla, Carlos Cativiela, Rosario González-Muñiz, Edurne Cenarruzabeitia, Joaquín Del Río, Diego Casabona, M. Jesús Pérez de Vega, Rosario Herranz, Sergio A. Alonso De Diego, M. Luisa Jimeno
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
A suitable solid-phase approach, based on Fmoc/tBu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity c