Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Diana Fontinha"'
Autor:
Akash Khandelwal, Francisca Arez, Paula M. Alves, Lassina Badolo, Catarina Brito, Christoph Fischli, Diana Fontinha, Claude Oeuvray, Miguel Prudêncio, Matthias Rottmann, Justin Wilkins, Özkan Yalkinoglu, Wilhelmina M. Bagchus, Thomas Spangenberg
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-7 (2022)
Abstract Background Targeting the asymptomatic liver stage of Plasmodium infection through chemoprevention could become a key intervention to reduce malaria-associated incidence and mortality. Methods M5717, a Plasmodium elongation factor 2 inhibitor
Externí odkaz:
https://doaj.org/article/1a184acca8e44dcf9fd53edb5f8e0845
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract With its strong effect on vector-borne diseases, and insecticidal effect on mosquito vectors of malaria, inhibition of sporogonic and blood-stage development of Plasmodium falciparum, as well as in vitro and in vivo impairment of the P. berg
Externí odkaz:
https://doaj.org/article/149da175938744f48ee85d5914039e14
Autor:
Américo J. S. Alves, Nuno G. Alves, Inês Bártolo, Diana Fontinha, Soraia Caetano, Miguel Prudêncio, Nuno Taveira, Teresa M. V. D. Pinho e Melo
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The molecular architecture of spirocyclic compounds has been widely explored within the medicinal chemistry field to obtain new compounds with singular three-dimensional pharmacophoric features and improved bioactivity. Herein, the synthesis of 68 ne
Externí odkaz:
https://doaj.org/article/5cc9ca220a9346a994a73430480ac15c
Autor:
Kateřina Hradiská Breiterová, Aneta Ritomská, Diana Fontinha, Jana Křoustková, Daniela Suchánková, Anna Hošťálková, Marcela Šafratová, Eliška Kohelová, Rozálie Peřinová, Rudolf Vrabec, Denise Francisco, Miguel Prudêncio, Lucie Cahlíková
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 1007 (2023)
The incidence rate of malaria and the ensuing mortality prompts the development of novel antimalarial drugs. In this work, the activity of twenty-eight Amaryllidaceae alkaloids (1–28) belonging to seven different structural types was assessed, as w
Externí odkaz:
https://doaj.org/article/5d092062cf334c5a91abe4f5fd1bdbb9
Autor:
Caroline De Souza Pereira, Helenita Costa Quadros, Samuel Yaw Aboagye, Diana Fontinha, Sarah D’Alessandro, Margaret Elizabeth Byrne, Mathieu Gendrot, Isabelle Fonta, Joel Mosnier, Diogo Rodrigo M. Moreira, Nicoletta Basilico, David L. Williams, Miguel Prudêncio, Bruno Pradines, Maribel Navarro
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1251 (2022)
Hybrid-based drugs linked through a transition metal constitute an emerging concept for Plasmodium intervention. To advance the drug design concept and enhance the therapeutic potential of this class of drugs, we developed a novel hybrid composed of
Externí odkaz:
https://doaj.org/article/90715f76ff9a42b483485c5b1afb6abd
Autor:
Patrícia Meireles, Daniela Brás, Diana Fontinha, Ângelo F. Chora, Karine Serre, António M. Mendes, Miguel Prudêncio
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101781- (2020)
Summary: Plasmodium parasites, causative agents of malaria, scavenge host nutrients to sustain their intracellular replication. Modulation of the host's nutritional status can potentially help control infection by limiting the parasite's access to nu
Externí odkaz:
https://doaj.org/article/cf90e60a758a4f5b82a322396bf0c3d3
Autor:
Helenita C. Quadros, Aysun Çapcı, Lars Herrmann, Sarah D’Alessandro, Diana Fontinha, Raquel Azevedo, Wilmer Villarreal, Nicoletta Basilico, Miguel Prudêncio, Svetlana B. Tsogoeva, Diogo R. M. Moreira
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1129 (2021)
A recently developed artemisinin-quinoline hybrid, named 163A, has been shown to display potent activity against the asexual blood stage of Plasmodium, the malaria parasite. In this study, we determined its in vitro cytotoxicity to mammalian cells, i
Externí odkaz:
https://doaj.org/article/0c90374b919e4727a3854b15ff3c116b
Autor:
Marina Marinović, Ivana Perković, Diana Fontinha, Miguel Prudêncio, Jana Held, Lais Pessanha de Carvalho, Tana Tandarić, Robert Vianello, Branka Zorc, Zrinka Rajić
Publikováno v:
Molecules, Vol 25, Iss 19, p 4376 (2020)
Harmicines represent hybrid compounds composed of β-carboline alkaloid harmine and cinnamic acid derivatives (CADs). In this paper we report the synthesis of amide-type harmicines and the evaluation of their biological activity. N-harmicines 5a–f
Externí odkaz:
https://doaj.org/article/0a56e61488f74a3da8ac621c3dd6b93e
Publikováno v:
Molecules, Vol 25, Iss 15, p 3409 (2020)
Malaria remains one of the most prevalent infectious diseases worldwide, primarily affecting some of the most vulnerable populations around the globe. Despite achievements in the treatment of this devastating disease, there is still an urgent need fo
Externí odkaz:
https://doaj.org/article/79c26b88dbad4154af008d4a26d632a6
Autor:
Maja Beus, Diana Fontinha, Jana Held, Zrinka Rajić, Lidija Uzelac, Marijeta Kralj, Miguel Prudêncio, Branka Zorc
Publikováno v:
Molecules, Vol 24, Iss 15, p 2812 (2019)
This paper describes a continuation of our efforts in the pursuit of novel antiplasmodial agents with optimized properties. Following our previous discovery of biologically potent asymmetric primaquine (PQ) and halogenaniline fumardiamides (1−6), w
Externí odkaz:
https://doaj.org/article/0dcd5656a7704c6b815ed852797d75e1