Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Diana Fandino"'
Autor:
Xuxu Gou, Beom-Jun Kim, Meenakshi Anurag, Jonathan T. Lei, Meggie N. Young, Matthew V. Holt, Diana Fandino, Craig T. Vollert, Purba Singh, Mohammad A. Alzubi, Anna Malovannaya, Lacey E. Dobrolecki, Michael T. Lewis, Shunqiang Li, Charles E. Foulds, Matthew J. Ellis
Publikováno v:
Cancer Research.
Transcriptionally active ESR1 gene fusions (ESR1-TAF) are a potent cause of breast cancer endocrine therapy (ET) resistance. ESR1-TAFs are not directly druggable because the C-terminal estrogen/anti-estrogen binding domain is replaced with translocat
Autor:
Matthew J. Ellis, Charles E. Foulds, Dan R. Robinson, Adrian V. Lee, Shunqiang Li, Alana L. Welm, Michael T. Lewis, Nicholas Mitsiades, Lacey E. Dobrolecki, Harshavardhan Doddapaneni, Viktoriya Korchina, Jianhong Hu, Saif Rehman, Airi Han, Diana Fandino, Sinem Seker, Purba Singh, Beom-Jun Kim, Jonathan T. Lei, Meenakshi Anurag, Xuxu Gou
Genomic analysis has recently identified multiple ESR1 gene translocations in estrogen receptor alpha–positive (ERα+) metastatic breast cancer (MBC) that encode chimeric proteins whereby the ESR1 ligand binding domain (LBD) is replaced by C-termin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e090b414964480174158dacb4554cb9f
https://doi.org/10.1158/0008-5472.c.6567232
https://doi.org/10.1158/0008-5472.c.6567232
Autor:
Matthew J. Ellis, Charles E. Foulds, Dan R. Robinson, Adrian V. Lee, Shunqiang Li, Alana L. Welm, Michael T. Lewis, Nicholas Mitsiades, Lacey E. Dobrolecki, Harshavardhan Doddapaneni, Viktoriya Korchina, Jianhong Hu, Saif Rehman, Airi Han, Diana Fandino, Sinem Seker, Purba Singh, Beom-Jun Kim, Jonathan T. Lei, Meenakshi Anurag, Xuxu Gou
It includes Supplementary Methods, Supplementary Figures, Supplementary Tables, and Supplementary References
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03910d32527d60325dbeb4475dd5b752
https://doi.org/10.1158/0008-5472.22569181.v1
https://doi.org/10.1158/0008-5472.22569181.v1
Autor:
Dan R. Robinson, Viktoriya Korchina, Xuxu Gou, Nicholas Mitsiades, Shunqiang Li, Jianhong Hu, Harshavardhan Doddapaneni, Matthew J. Ellis, Purba Singh, Beom-Jun Kim, Alana L. Welm, Michael T. Lewis, Diana Fandino, Lacey E. Dobrolecki, Meenakshi Anurag, Sinem Seker, Jonathan T. Lei, Airi Han, Saif Rehman, Adrian V. Lee, Charles E. Foulds
Publikováno v:
Cancer Res
Genomic analysis has recently identified multiple ESR1 gene translocations in estrogen receptor alpha–positive (ERα+) metastatic breast cancer (MBC) that encode chimeric proteins whereby the ESR1 ligand binding domain (LBD) is replaced by C-termin
Autor:
Xuxu Gou, Craig T. Vollert, Yue Chen, Diana Fandino, Matthew V. Holt, Beom-Jun Kim, Qin Feng, Jin Wang, David M. Lonard, Bert W. O'Malley, Matthew J. Ellis, Charles E. Foulds
Publikováno v:
Cancer Research. 83:LB134-LB134
Background: In-frame chimeric proteins that are encoded by ESR1 exons 1 to 6 (ESR1-e6) fused to C-terminal gene partners can induce hormone-independent growth and endocrine therapy (ET) resistance of estrogen receptor-α (ERα) positive breast cancer
Autor:
Xuxu Gou, Beom-Jun Kim, Meenakshi Anurag, Jonathan T. Lei, Meggie N. Young, Matthew V. Holt, Diana Fandino, Craig T. Vollert, Purba Singh, Mohammad A. Alzubi, Anna Malovannaya, Lacey E. Dobrolecki, Michael T. Lewis, Shunqiang Li, Matthew J. Ellis, Charles E. Foulds
Publikováno v:
Cancer Research. 83:5011-5011
Background: Transcriptionally active ESR1 gene fusions (ESR1-TAF) are a potent cause of estrogen receptor alpha-positive (ERα+) breast cancer endocrine therapy (ET) resistance. These ESR1-TAF are gain-of-function mutations, exhibiting estrogen-indep
Autor:
Xuxu Gou, Beom-Jun Kim, Meenakshi Anurag, Matthew Valle Holt, Meggie Nguyen Young, Jonathan Thomas Lei, Diana Fandino, Craig T. Vollert, Purba Singh, Mohammad A. Alzubi, Lacey Elizabeth Dobrolecki, Michael Lewis, Alana Welm, Shunqiang Li, Charles Edward Foulds, Matthew James Ellis
Publikováno v:
Journal of Clinical Oncology. 40:1085-1085
1085 Background: Genomic analysis has recently identified multiple ESR1 gene translocations in estrogen receptor-alpha positive (ERα+) metastatic breast cancer (MBC) that encode chimeric proteins whereby the ESR1 ligand binding domain is replaced by