Výsledky vyhledávání - "Diana F. Lázaro"

Akademický článek

Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo

Autor: Antonio Dominguez-Meijide, Valeria Parrales, Eftychia Vasili, Florencia González-Lizárraga, Annekatrin König, Diana F. Lázaro, Annie Lannuzel, Stéphane Haik, Elaine Del Bel, Rosana Chehín, Rita Raisman-Vozari, Patrick P. Michel, Nicolas Bizat, Tiago Fleming Outeiro

Publikováno v: Neurobiology of Disease, Vol 151, Iss , Pp 105256- (2021)

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn). Doxycycline, a tetracyclic antibiotic shows neuroprotective effects, initially pro

Externí odkaz: https://doaj.org/article/552ebd9e8d364a10af46c4b3b62a5775

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Akademický článek

Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation

Autor: Blagovesta Popova, Dan Wang, Abirami Rajavel, Karthikeyan Dhamotharan, Diana F. Lázaro, Jennifer Gerke, Joachim F. Uhrig, Michael Hoppert, Tiago F. Outeiro, Gerhard H. Braus

Publikováno v: Frontiers in Molecular Neuroscience, Vol 14 (2021)

Aggregation of α-synuclein (αSyn) into proteinaceous deposits is a pathological hallmark of a range of neurodegenerative diseases including Parkinson’s disease (PD). Numerous lines of evidence indicate that the accumulation of toxic oligomeric an

Externí odkaz: https://doaj.org/article/e91dcc1af7564367b8b5800b2776ae2c

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Akademický článek

Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases

Autor: Diana F. Lázaro, Arianna Bellucci, Patrik Brundin, Tiago F. Outeiro

Publikováno v: Frontiers in Molecular Neuroscience, Vol 12 (2020)

Externí odkaz: https://doaj.org/article/13c44badcd4f49f597ac739d0392f9f9

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Akademický článek

Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function

Publikováno v: Neurobiology of Disease, Vol 119, Iss , Pp 121-135 (2018)

Alpha-synuclein (aSyn) is the major protein component of Lewy bodies and Lewy neurites, the typical pathological hallmarks in Parkinson's disease (PD) and Dementia with Lewy bodies. aSyn is capable of inducing transcriptional deregulation, but the pr

Externí odkaz: https://doaj.org/article/75ce3a76847041c5a470e50f98fcc59a

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Akademický článek

α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner

Autor: Guowei Yin, Tomas Lopes da Fonseca, Sibylle E. Eisbach, Ane Martín Anduaga, Carlo Breda, Maria L. Orcellet, Éva M. Szegő, Patricia Guerreiro, Diana F. Lázaro, Gerhard H. Braus, Claudio O. Fernandez, Christian Griesinger, Stefan Becker, Roger S. Goody, Aymelt Itzen, Flaviano Giorgini, Tiago F. Outeiro, Markus Zweckstetter

Publikováno v: Neurobiology of Disease, Vol 70, Iss , Pp 149-161 (2014)

Alpha-synuclein (αS) misfolding is associated with Parkinson's disease (PD) but little is known about the mechanisms underlying αS toxicity. Increasing evidence suggests that defects in membrane transport play an important role in neuronal dysfunct

Externí odkaz: https://doaj.org/article/7480409adf064c3290f3436c07a5b54c

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Alpha-synuclein induces epigenomic dysregulation of glutamate signaling and locomotor pathways

Autor: Schaffner Sl, Michael S. Kobor, Wassouf Z, Lin Dts, Tiago F. Outeiro, Diana F. Lázaro, Katia E Ramadori, Mary Xylaki, Nicole Gladish, Julia M. Schulze-Hentrich, J.L. MacIsaac

BackgroundMutations and multiplications in the gene encoding for alpha-synuclein are associated with Parkinson’s disease (PD). However, not all individuals with alpha-synuclein variants develop PD, suggesting that additional factors are involved. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f1a4527548562f2761d6fc52325ba18
https://doi.org/10.1101/2021.06.12.448150

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Super-resolution microscopy informs on the molecular architecture of alpha-synuclein inclusions in model systems and in the human brain

Autor: Stadelmann C, Hoeglinger Gu, Weish P, Patrícia I. Santos, Tiago F. Outeiro, Silvio O. Rizzoli, Palmares L, Diana F. Lázaro

Lewy bodies (LBs) and Lewy neurites are pathological hallmarks of Parkinson’s disease and other progressive neurodegenerative disorders known as Lewy body diseases (LBD). These proteinaceous deposits are immunopositive for alpha-synuclein (aSyn) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e308410752496c4c5d087c886e8d778
https://doi.org/10.1101/2021.04.25.441304

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Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo

Autor: Elaine Aparecida Del Bel, Diana F. Lázaro, Nicolas Bizat, Patrick P. Michel, Rosana Chehín, Valeria Parrales, Eftychia Vasili, Antonio Dominguez-Meijide, Tiago F. Outeiro, Annie Lannuzel, Stéphane Haik, Annekatrin König, R. Raisman-Vozari, Florencia González-Lizárraga

Publikováno v: Neurobiology of Disease
Neurobiology of Disease, Elsevier, 2021, 151, pp.105256. ⟨10.1016/j.nbd.2021.105256⟩
Neurobiology of Disease, Vol 151, Iss, Pp 105256-(2021)
Neurobiology of Disease, 2021, 151, pp.105256. ⟨10.1016/j.nbd.2021.105256⟩
Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela
Universidad de Santiago de Compostela (USC)
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname

International audience; Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn). Doxycycline, a tetracyclic antibiotic shows neuroprotectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04742017d14d77fe2b75dbda119fb1e0
https://hal.sorbonne-universite.fr/hal-03195956/file/1-s2.0-S096999612100005X-main.pdf

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DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization

Autor: Blagovesta Popova, Dan Wang, Christina Pätz, Dagmar Akkermann, Diana F Lázaro, Dajana Galka, Miriam Kolog Gulko, Markus T Bohnsack, Wiebke Möbius, Katherine E Bohnsack, Tiago F Outeiro, Gerhard H Braus

Publikováno v: PLoS Genetics, Vol 17, Iss 3, p e1009407 (2021)

Parkinson's disease is a neurodegenerative disorder associated with misfolding and aggregation of α-synuclein as a hallmark protein. Two yeast strain collections comprising conditional alleles of essential genes were screened for the ability of each

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::12f3fa7a3f70c79fd85bc7884aa6d84e
https://doaj.org/article/defe2fff7f0f48ecaaf115a39f833b13

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In silico analysis of the aggregation propensity of the SARS-CoV-2 proteome: Insight into possible cellular pathologies

Autor: Anita Krisko, Tiago F. Outeiro, Manuel Flores-León, Diana F. Lázaro, Liana Shvachiy

Publikováno v: Biochimica et biophysica acta / Proteins and proteomics 1869(10), 140693 (2021). doi:10.1016/j.bbapap.2021.140693
Biochimica et Biophysica Acta. Proteins and Proteomics

The SARS-CoV-2 virus causes the coronavirus disease 19 emerged in 2020. The pandemic triggered a turmoil in public health and is having a tremendous social and economic impact around the globe. Upon entry into host cells, the SARS-CoV-2 virus hijacks

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5e3302f41d3ee8b3a2526f7302e165
https://pub.dzne.de/record/155650

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