Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Diana F. Colgan"'
Publikováno v:
Exp Hematol
The Gon4l gene encodes a putative transcriptional regulator implicated in the control of both cell differentiation and proliferation. Previously, we described a mutant mouse strain called Justy in which splicing of pre-mRNA generated from Gon4l is di
Autor:
Neil A. Feldstein, Jin Yang, Chun Wei Hsu, Xiaorong Li, Scott Smemo, Vinit B. Mahajan, Andrew J. Grossbach, Yasunori Nagahama, Stephen H. Tsang, Juliane Merl-Pham, Lijuan Zhang, Stefanie M. Hauck, Diana F. Colgan, Kit Sing Au, Marius Ueffing, Hope Northrup, Sally Justus, William B. Dobyns, Alexander G. Bassuk, Matthew A. Howard, Hiroto Kawasaki
Publikováno v:
Hum. Mol. Genet. 25, 4201-4210 (2016)
Inactivating mutations of the TSC1/TSC2 complex (TSC1/2) cause tuberous sclerosis (TSC), a hereditary syndrome with neurological symptoms and benign hamartoma tumors in the brain. Since TSC effectors are largely unknown in the human brain, TSC patien
Background In patients with limited response to conventional therapeutics, repositioning of already approved drugs can bring new, more effective options. Current drug repositioning methods, however, frequently rely on retrospective computational anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225587c59694ba05f6e66893d33bcc6a
https://europepmc.org/articles/PMC5752263/
https://europepmc.org/articles/PMC5752263/
Autor:
Stephen H. Tsang, Vinit B. Mahajan, Kellie A. Schaefer, Benjamin W. Darbro, Diana F. Colgan, Alexander G. Bassuk
Our previous publication suggested CRISPR-Cas9 editing at the zygotic stage might unexpectedly introduce a multitude of subtle but unintended mutations, an interpretation that not surprisingly raised numerous questions. The key issue is that since pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5eeb34d2a6569679c3ac1088f7c368a
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 198(10)
B cell development in Justy mutant mice is blocked due to a precursor mRNA splicing defect that depletes the protein GON4-like (GON4L) in B cell progenitors. Genetic and biochemical studies have suggested that GON4L is a transcriptional regulator tha
Autor:
Chen Guang Yu, Marcus A. Toral, Diana F. Colgan, Vimala Bondada, Vinit B. Mahajan, Alexander G. Bassuk, Gabriel Velez, Kellie A. Schaefer, James W. Geddes, Charles B. Mashburn, Stephen H. Tsang, Nicholas Borcherding, Sheila A. Baker, Allison Cox
Publikováno v:
Investigative Ophthalmology & Visual Science
PURPOSE We characterize calpain-5 (CAPN5) expression in retinal and neuronal subcellular compartments. METHODS CAPN5 gene variants were classified using the exome variant server, and RNA-sequencing was used to compare expression of CAPN5 mRNA in the
Autor:
Stephen H. Tsang, Alexander G. Bassuk, Vinit B. Mahajan, Diana F. Colgan, Wen-Hsuan Wu, Kellie A. Schaefer
Publikováno v:
Nature Methods. 14:547-548
Nat. Methods 14, 547–548 (2017); published online 30 May 2017; updated online 14 June 2017; corrected online 25 July 2017; retracted 30 March 2018 This paper is being retracted because the genomic variants observed by the authors in two CRISPR-trea
Autor:
Stephen H. Tsang, Vinit B. Mahajan, Diana F. Colgan, Kellie A. Schaefer, Wen-Hsuan Wu, Alexander G. Bassuk
Publikováno v:
Nature Methods. 15:394-394
Nat. Methods 14, 547–548 (2017); published online 30 May 2017; updated online 14 June 2017; corrected online 25 July 2017; retracted 30 March 2018 This paper is being retracted because the genomic variants observed by the authors in two CRISPR-trea
Publikováno v:
The Journal of biological chemistry. 282(16)
To identify new sequence elements in the promoter that affect splicing patterns of pre-mRNAs, we analyzed effects of different promoters on alternative splicing of model reporter genes. We compared the E1a alternative splicing pattern in transcripts
Autor:
Peter Mombaerts, Makoto Tachibana, Robert J. Blanchard, Kellie L.K. Tamashiro, Kentaro Tanemura, Anthony C.F. Perry, Hiroyuki Niida, Yoichi Shinkai, Teruhiko Wakayama, Ryuzo Yanagimachi, Atsuo Ogura, D. Caroline Blanchard, Diana F. Colgan
Publikováno v:
Nature. 407(6802)
Mice have been cloned by nuclear transfer into enucleated oocytes1,2,3, and here we describe the reiterative cloning of mice to four and six generations in two independent lines. Successive generations showed no signs of prematureageing, as judged by