Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Diana F, Lázaro"'
Autor:
Antonio Dominguez-Meijide, Valeria Parrales, Eftychia Vasili, Florencia González-Lizárraga, Annekatrin König, Diana F. Lázaro, Annie Lannuzel, Stéphane Haik, Elaine Del Bel, Rosana Chehín, Rita Raisman-Vozari, Patrick P. Michel, Nicolas Bizat, Tiago Fleming Outeiro
Publikováno v:
Neurobiology of Disease, Vol 151, Iss , Pp 105256- (2021)
Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn). Doxycycline, a tetracyclic antibiotic shows neuroprotective effects, initially pro
Externí odkaz:
https://doaj.org/article/552ebd9e8d364a10af46c4b3b62a5775
Autor:
Blagovesta Popova, Dan Wang, Abirami Rajavel, Karthikeyan Dhamotharan, Diana F. Lázaro, Jennifer Gerke, Joachim F. Uhrig, Michael Hoppert, Tiago F. Outeiro, Gerhard H. Braus
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Aggregation of α-synuclein (αSyn) into proteinaceous deposits is a pathological hallmark of a range of neurodegenerative diseases including Parkinson’s disease (PD). Numerous lines of evidence indicate that the accumulation of toxic oligomeric an
Externí odkaz:
https://doaj.org/article/e91dcc1af7564367b8b5800b2776ae2c
Autor:
Blagovesta Popova, Dan Wang, Christina Pätz, Dagmar Akkermann, Diana F Lázaro, Dajana Galka, Miriam Kolog Gulko, Markus T Bohnsack, Wiebke Möbius, Katherine E Bohnsack, Tiago F Outeiro, Gerhard H Braus
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1009407 (2021)
Parkinson's disease is a neurodegenerative disorder associated with misfolding and aggregation of α-synuclein as a hallmark protein. Two yeast strain collections comprising conditional alleles of essential genes were screened for the ability of each
Externí odkaz:
https://doaj.org/article/defe2fff7f0f48ecaaf115a39f833b13
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2020)
Externí odkaz:
https://doaj.org/article/13c44badcd4f49f597ac739d0392f9f9
Autor:
Isabel Paiva, Gaurav Jain, Diana F. Lázaro, Kristina Gotovac Jerčić, Thomas Hentrich, Cemil Kerimoglu, Raquel Pinho, Èva M. Szegő, Susanne Burkhardt, Vincenzo Capece, Rashi Halder, Rezaul Islam, Mary Xylaki, Lucas A. Caldi Gomes, Anna-Elisa Roser, Paul Lingor, Julia M. Schulze-Hentrich, Fran Borovečki, André Fischer, Tiago F. Outeiro
Publikováno v:
Neurobiology of Disease, Vol 119, Iss , Pp 121-135 (2018)
Alpha-synuclein (aSyn) is the major protein component of Lewy bodies and Lewy neurites, the typical pathological hallmarks in Parkinson's disease (PD) and Dementia with Lewy bodies. aSyn is capable of inducing transcriptional deregulation, but the pr
Externí odkaz:
https://doaj.org/article/75ce3a76847041c5a470e50f98fcc59a
Autor:
Rita Machado de Oliveira, Hugo Vicente Miranda, Laetitia Francelle, Raquel Pinho, Éva M Szegö, Renato Martinho, Francesca Munari, Diana F Lázaro, Sébastien Moniot, Patrícia Guerreiro, Luis Fonseca-Ornelas, Zrinka Marijanovic, Pedro Antas, Ellen Gerhardt, Francisco Javier Enguita, Bruno Fauvet, Deborah Penque, Teresa Faria Pais, Qiang Tong, Stefan Becker, Sebastian Kügler, Hilal Ahmed Lashuel, Clemens Steegborn, Markus Zweckstetter, Tiago Fleming Outeiro
Publikováno v:
PLoS Biology, Vol 15, Iss 4, p e1002601 (2017)
[This corrects the article DOI: 10.1371/journal.pbio.2000374.].
Externí odkaz:
https://doaj.org/article/fb415e7f10954b03bf291185f961cdfc
Autor:
Rita Machado de Oliveira, Hugo Vicente Miranda, Laetitia Francelle, Raquel Pinho, Éva M Szegö, Renato Martinho, Francesca Munari, Diana F Lázaro, Sébastien Moniot, Patrícia Guerreiro, Luis Fonseca-Ornelas, Zrinka Marijanovic, Pedro Antas, Ellen Gerhardt, Francisco Javier Enguita, Bruno Fauvet, Deborah Penque, Teresa Faria Pais, Qiang Tong, Stefan Becker, Sebastian Kügler, Hilal Ahmed Lashuel, Clemens Steegborn, Markus Zweckstetter, Tiago Fleming Outeiro
Publikováno v:
PLoS Biology, Vol 15, Iss 3, p e2000374 (2017)
Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as Alzheimer and Parkinson dis
Externí odkaz:
https://doaj.org/article/989eaa37ca2a44718ed354a73c818f4e
Autor:
Guowei Yin, Tomas Lopes da Fonseca, Sibylle E. Eisbach, Ane Martín Anduaga, Carlo Breda, Maria L. Orcellet, Éva M. Szegő, Patricia Guerreiro, Diana F. Lázaro, Gerhard H. Braus, Claudio O. Fernandez, Christian Griesinger, Stefan Becker, Roger S. Goody, Aymelt Itzen, Flaviano Giorgini, Tiago F. Outeiro, Markus Zweckstetter
Publikováno v:
Neurobiology of Disease, Vol 70, Iss , Pp 149-161 (2014)
Alpha-synuclein (αS) misfolding is associated with Parkinson's disease (PD) but little is known about the mechanisms underlying αS toxicity. Increasing evidence suggests that defects in membrane transport play an important role in neuronal dysfunct
Externí odkaz:
https://doaj.org/article/7480409adf064c3290f3436c07a5b54c
Autor:
Alexandra Kleinknecht, Blagovesta Popova, Diana F Lázaro, Raquel Pinho, Oliver Valerius, Tiago F Outeiro, Gerhard H Braus
Publikováno v:
PLoS Genetics, Vol 12, Iss 6, p e1006098 (2016)
Parkinson´s disease (PD) is characterized by the presence of proteinaceous inclusions called Lewy bodies that are mainly composed of α-synuclein (αSyn). Elevated levels of oxidative or nitrative stresses have been implicated in αSyn related toxic
Externí odkaz:
https://doaj.org/article/faf775e093e24380b82b2f7f22777c03
Autor:
Schaffner Sl, Michael S. Kobor, Wassouf Z, Lin Dts, Tiago F. Outeiro, Diana F. Lázaro, Katia E Ramadori, Mary Xylaki, Nicole Gladish, Julia M. Schulze-Hentrich, J.L. MacIsaac
BackgroundMutations and multiplications in the gene encoding for alpha-synuclein are associated with Parkinson’s disease (PD). However, not all individuals with alpha-synuclein variants develop PD, suggesting that additional factors are involved. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f1a4527548562f2761d6fc52325ba18
https://doi.org/10.1101/2021.06.12.448150
https://doi.org/10.1101/2021.06.12.448150
