Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Diana Ekman"'
Autor:
Marcin Kierczak, Nima Rafati, Julia Höglund, Hadrien Gourlé, Valeria Lo Faro, Daniel Schmitz, Weronica E. Ek, Ulf Gyllensten, Stefan Enroth, Diana Ekman, Björn Nystedt, Torgny Karlsson, Åsa Johansson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Despite the success of genome-wide association studies, much of the genetic contribution to complex traits remains unexplained. Here, the authors identify effects by rare variants on plasma proteins, and estimate the contribution of rare variants to
Externí odkaz:
https://doaj.org/article/1070fe1cf0884dc9a1fe9d7ebf5b6af9
Autor:
Maria Needhamsen, Payam Emami Khoonsari, Galina Yurevna Zheleznyakova, Eliane Piket, Michael Hagemann-Jensen, Yanan Han, Jannik Gierlich, Diana Ekman, Maja Jagodic
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Multiple Sclerosis (MS) is an autoimmune, neurological disease, commonly presenting with a relapsing-remitting form, that later converts to a secondary progressive stage, referred to as RRMS and SPMS, respectively. Early treatment slows disease progr
Externí odkaz:
https://doaj.org/article/6f556f2bd62540d485b1e3fcd4e3ba0a
Autor:
Ulrika Norin, Carola Rintisch, Liesu Meng, Florian Forster, Diana Ekman, Jonatan Tuncel, Katrin Klocke, Johan Bäcklund, Min Yang, Michael Y. Bonner, Gonzalo Fernandez Lahore, Jaime James, Klementy Shchetynsky, Maria Bergquist, Inger Gjertsson, Norbert Hubner, Liselotte Bäckdahl, Rikard Holmdahl
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The autoimmune disorder, rheumatoid arthritis (RA), has been associated with multiple pathophysiological factors. Here the authors show that deficiency in endophilin A2 in rodents protects them from experimental arthritis by altering T cell activatio
Externí odkaz:
https://doaj.org/article/2c060b0a7c8b44caaf676f45fd6b218d
Autor:
Alvaro Martinez Barrio, Sangeet Lamichhaney, Guangyi Fan, Nima Rafati, Mats Pettersson, He Zhang, Jacques Dainat, Diana Ekman, Marc Höppner, Patric Jern, Marcel Martin, Björn Nystedt, Xin Liu, Wenbin Chen, Xinming Liang, Chengcheng Shi, Yuanyuan Fu, Kailong Ma, Xiao Zhan, Chungang Feng, Ulla Gustafson, Carl-Johan Rubin, Markus Sällman Almén, Martina Blass, Michele Casini, Arild Folkvord, Linda Laikre, Nils Ryman, Simon Ming-Yuen Lee, Xun Xu, Leif Andersson
Publikováno v:
eLife, Vol 5 (2016)
Ecological adaptation is of major relevance to speciation and sustainable population management, but the underlying genetic factors are typically hard to study in natural populations due to genetic differentiation caused by natural selection being co
Externí odkaz:
https://doaj.org/article/6a1c8f44e277485c8ccd4757a747192d
Autor:
Jonatan Tuncel, Sabrina Haag, Anthony C Y Yau, Ulrika Norin, Amelie Baud, Erik Lönnblom, Klio Maratou, A Jimmy Ytterberg, Diana Ekman, Soley Thordardottir, Martina Johannesson, Alan Gillett, EURATRANS Consortium, Pernilla Stridh, Maja Jagodic, Tomas Olsson, Alberto Fernández-Teruel, Roman A Zubarev, Richard Mott, Timothy J Aitman, Jonathan Flint, Rikard Holmdahl
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004151 (2014)
Genetic variation in the major histocompatibility complex (MHC) affects CD4∶CD8 lineage commitment and MHC expression. However, the contribution of specific genes in this gene-dense region has not yet been resolved. Nor has it been established whet
Externí odkaz:
https://doaj.org/article/626b76e763964d4b96c17efc72bbb0ba
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 8, p e114 (2006)
Many proteins, especially in eukaryotes, contain tandem repeats of several domains from the same family. These repeats have a variety of binding properties and are involved in protein-protein interactions as well as binding to other ligands such as D
Externí odkaz:
https://doaj.org/article/0fbadb60b6894a5eb508d202a9bbc067
Autor:
Diana Ekman, Bengt Sennblad, Ann Knight, Åsa Karlsson, Solbritt Rantapää-Dahlqvist, Ewa Berglin, Bernd Stegmayr, Bo Baslund, Øyvind Palm, Hilde Haukeland, Iva Gunnarsson, Annette Bruchfeld, Mårten Segelmark, Sophie Ohlsson, Aladdin J Mohammad, Anna Svärd, Rille Pullerits, Hans Herlitz, Annika Söderbergh, Roald Omdal, Roland Jonsson, Lars Rönnblom, Per Eriksson, Kerstin Lindblad-Toh, Johanna Dahlqvist
Publikováno v:
Rheumatology.
Objective To identify and genetically characterize subgroups of patients with ANCA-associated vasculitides (AAV) based on sex and ANCA subtype. Methods A previously established SNP dataset derived from DNA sequencing of 1853 genes and genotyping of 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::450f74bcafc9ab1290959e43e6e94df2
https://doi.org/10.1093/rheumatology/kead152
https://doi.org/10.1093/rheumatology/kead152
Autor:
Hadrien Gourlé, Stefan Enroth, Åsa Johansson, Diana Ekman, Björn Nystedt, Julia Höglund, Nima Rafati, Daniel Schmitz, Torgny Karlsson, Marcin Kierczak, Weronica E. Ek
Despite the success in identifying effects of common genetic variants, using genome-wide association studies (GWAS), much of the genetic contribution to complex traits remains unexplained. Here, we analysed high coverage whole-genome sequencing (WGS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a33e484f032ca1e010ac97a9439a5adc
https://doi.org/10.21203/rs.3.rs-625433/v1
https://doi.org/10.21203/rs.3.rs-625433/v1
Autor:
Jonatan Tuncel, Florian Forster, Klementy Shchetynsky, Liselotte Bäckdahl, Liesu Meng, Inger Gjertsson, Norbert Hubner, Rikard Holmdahl, Michael Y. Bonner, Johan Bäcklund, Ulrika Norin, Min Yang, Jaime James, Katrin Klocke, Maria Bergquist, Gonzalo Fernandez Lahore, Diana Ekman, Carola Rintisch
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The introduction of the CTLA-4 recombinant fusion protein has demonstrated therapeutic effects by selectively modulating T-cell activation in rheumatoid arthritis. Here we show, using a forward genetic approach, that a mutation in the SH3gl1 gene enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91549c95f91a24bfe26fa5795ca6c7f
http://edoc.mdc-berlin.de/19925/2/19925suppl.zip
http://edoc.mdc-berlin.de/19925/2/19925suppl.zip
Autor:
Linda Laikre, Verena E. Kutschera, Diana Ekman, Naomi L. P. Keehnen, Gunnar Ståhl, Nils Ryman, Sara Kurland, Fred W. Allendorf, Anastasia Andersson, Atal Saha, Marty Kardos, Sten Karlsson, Ola Hössjer
Publikováno v:
Molecular Ecology
The sympatric existence of genetically distinguishable populations of the same species remains a puzzle in ecology. Coexisting salmonid fish populations are known from over 100 freshwater lakes. Most studies of sympatric populations have used limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770b21aadc27416f9f898518777a64bd
https://doi.org/10.22541/au.161035029.98155231/v1
https://doi.org/10.22541/au.161035029.98155231/v1