Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Diana E M, Dolman"'
Publikováno v:
Drug Delivery to the Brain ISBN: 9783030887728
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::193f1343b1e5cd67276521e29540865e
https://doi.org/10.1007/978-3-030-88773-5_8
https://doi.org/10.1007/978-3-030-88773-5_8
Publikováno v:
Neurobiology of Disease, Vol 37, Iss 1, Pp 13-25 (2010)
Neural signalling within the central nervous system (CNS) requires a highly controlled microenvironment. Cells at three key interfaces form barriers between the blood and the CNS: the blood-brain barrier (BBB), blood-CSF barrier and the arachnoid bar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc13bac3349ee1fe73102789d66fa48b
http://www.sciencedirect.com/science/article/pii/S0969996109002083
http://www.sciencedirect.com/science/article/pii/S0969996109002083
Publikováno v:
Current Drug Metabolism. 9:901-910
Drug discovery programmes to target or avoid the brain need to take into account the properties of the blood-brain barrier (BBB). The importance to CNS PK of the free drug concentration in brain is increasingly recognised, and assays for drug discove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa1a81d2f4dd07a705dde4d716a022a
https://doi.org/10.2174/138920008786485182
https://doi.org/10.2174/138920008786485182
Publikováno v:
Drug Delivery to the Brain ISBN: 9781461491040
This chapter reviews the history and modern applications of isolated preparations of the three main CNS barrier layers and cell culture preparations derived from them. In vitro models give valuable mechanistic information but also provide useful assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c08442714c0c89832812b361ed376949
https://doi.org/10.1007/978-1-4614-9105-7_6
https://doi.org/10.1007/978-1-4614-9105-7_6
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 814
In vitro blood-brain barrier (BBB) models using primary cultured brain endothelial cells are important for establishing cellular and molecular mechanisms of BBB function. Co-culturing with BBB-associated cells especially astrocytes to mimic more clos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::95ca9bcf485b1445785f573890c6df27
https://pubmed.ncbi.nlm.nih.gov/22144323
https://pubmed.ncbi.nlm.nih.gov/22144323
Publikováno v:
Methods in Molecular Biology ISBN: 9781617794513
In vitro blood-brain barrier (BBB) models using primary cultured brain endothelial cells are important for establishing cellular and molecular mechanisms of BBB function. Co-culturing with BBB-associated cells especially astrocytes to mimic more clos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07638d24e877c61d08a49e4aab2159cb
https://doi.org/10.1007/978-1-61779-452-0_28
https://doi.org/10.1007/978-1-61779-452-0_28
Publikováno v:
Experimental eye research. 83(1)
P-Glycoprotein (P-gp), an active efflux transporter encoded by the MDR1 gene, has recently been identified in the human and pig retinal pigment epithelium (RPE) in situ. Efflux pumps such as P-gp are major barriers to drug delivery in several tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7b7cd28b61936de4c25b7efd13c4e6
https://pubmed.ncbi.nlm.nih.gov/16530756
https://pubmed.ncbi.nlm.nih.gov/16530756
Publikováno v:
Journal of neurochemistry. 93(4)
Aquaporins (AQPs) are a family of proteins that mediate water transport across cells, but the extent to which they are involved in water transport across endothelial cells of the blood-brain barrier is not clear. Expression of AQP1 and AQP4 in rat br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a1d36aeadd4362effcd3997a30bad4
https://pubmed.ncbi.nlm.nih.gov/15857386
https://pubmed.ncbi.nlm.nih.gov/15857386
Publikováno v:
Brain Research. 1012:185-186
Following a recent claim, based on glial acidic fibrillary protein (GFAP) expression, that brain-derived astrocytes in culture are in fact endothelial cells, we immuno-labelled primary cultures of rat brain astrocytes and endothelium with various GFA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec49bd22dc8172b3c3dac87a302844b
https://doi.org/10.1016/j.brainres.2004.03.033
https://doi.org/10.1016/j.brainres.2004.03.033