Výsledky vyhledávání - "Diana D. Y. Wong"

Human Cytomegalovirus Modulates Expression of Noncanonical Wnt Receptor ROR2 To Alter Trophoblast Migration

Autor: Caroline E. Ford, William D. Rawlinson, Wendy J. van Zuylen, Diana D. Y. Wong

Publikováno v: Journal of Virology. 90:1108-1115

Maternal primary cytomegalovirus (CMV) infection, reactivation, or reinfection with a different viral strain may cause fetal injury and adverse pregnancy outcomes. Increasing evidence indicates that fetal injury results not only from direct viral cyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc373f88eb590c54d40287816a29a4f9
https://doi.org/10.1128/jvi.02588-15

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Resistance to Neuraminidase Inhibitors Conferred by an R292K Mutation in a Human Influenza Virus H7N9 Isolate Can Be Masked by a Mixed R/K Viral Population

Autor: Peter Pak-Hang Cheung, Robert G. Webster, Ka-Tim Choy, Joseph S. M. Peiris, Iris H. Y. Ng, Jie Zhou, Yi Guan, Hui-Ling Yen, Diana D. Y. Wong, Richard J. Webby, JL McKimm-Breschkin, Hongbo Zhu

Publikováno v: mBio
mBio, Vol 4, Iss 4 (2013)

We characterized the A/Shanghai/1/2013 virus isolated from the first confirmed human case of A/H7N9 disease in China. The A/Shanghai/1/2013 isolate contained a mixed population of R (65%; 15/23 clones) and K (35%; 8/23 clones) at neuraminidase (NA) r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644aa1e7debd0ae21e9a46a790aafe58
https://doi.org/10.1128/mbio.00396-13

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Comparable fitness and transmissibility between oseltamivir-resistant pandemic 2009 and seasonal H1N1 influenza viruses with the H275Y neuraminidase mutation

Autor: Renee W. Y. Chan, Hui-Ling Yen, Hsin-Ping Chiu, Sin Fun Sia, Diana D. Y. Wong, Ka-Tim Choy, Michael C. W. Chan, J. S. Malik Peiris, Pak Hang Peter Cheung

Limited antiviral compounds are available for the control of influenza, and the emergence of resistant variants would further narrow the options for defense. The H275Y neuraminidase (NA) mutation, which confers resistance to oseltamivir carboxylate,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e051d795dc4757cb264d902c7ff3ad
http://hdl.handle.net/10722/161160

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Tissue tropism of swine influenza viruses and reassortants in ex vivo cultures of the human respiratory tract and conjunctiva

Autor: Leo L.M. Poon, Sara S R Kang, Wendy C. L. Yu, Alan C. L. Li, Renee W. Y. Chan, Michael C. W. Chan, Lynsia L. S. Tang, J. S. Malik Peiris, Yi Guan, Hui-Ling Yen, Alan D. L. Sihoe, Icarus W. W. Chan, Diana D. Y. Wong, Kit M. Yuen, John M. Nicholls, Wico W. Lai, Dora L.W. Kwong

Publikováno v: Journal of virology. 85(22)

The 2009 pandemic influenza H1N1 (H1N1pdm) virus was generated by reassortment of swine influenza viruses of different lineages. This was the first influenza pandemic to emerge in over 4 decades and the first to occur after the realization that influ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9fad140111ea770df188a2a3f27ca8
https://pubmed.ncbi.nlm.nih.gov/21880750

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Generation and characterization of influenza A viruses with altered polymerase fidelity

Autor: Peter Pak-Hang Cheung, Hui-Ling Yen, Sin Fun Sia, J. S. Malik Peiris, Leo L.M. Poon, Ka-Tim Choy, Simon J. Watson, Diana D. Y. Wong, Yi Guan, Paul Kellam

Publikováno v: Nature communications

Genetic diversity of influenza A viruses (IAV) acquired through the error-prone RNA-dependent RNA polymerase (RdRP) or through genetic reassortment enables perpetuation of IAV in humans through epidemics or pandemics. Here, to assess the biological s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f44e647260ff1cf99515a2a372db1e
http://europepmc.org/articles/PMC4155405

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