Stress-Dependent Nucleolin Mobilization Mediated by p53-Nucleolin Complex Formation

Autor: James A. Borowiec, Diana D. Dimitrova, Yaron Daniely

Publikováno v: Molecular and Cellular Biology. 22:6014-6022

We recently discovered that heat shock causes nucleolin to relocalize from the nucleolus to the nucleoplasm, whereupon it binds replication protein A and inhibits DNA replication initiation. We report that nucleolin mobilization also occurs following

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae3fffce50ae1005d0fb16fa80d357f
https://doi.org/10.1128/mcb.22.16.6014-6022.2002

DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe

Autor: Jac A. Nickoloff, Brock J. Sishc, Stephen O. Opiyo, Gregory G. Oakley, Shengqin Liu, Phuong Le, Jason G. Glanzer, Kyle Troksa, Meena Shrivastav, Amanda K. Ashley, Susan M. Bailey, Courtney Amerin, Jingyi Nie, Diana D. Dimitrova

Publikováno v: DNA repair. 21

Genotoxins and other factors cause replication stress that activate the DNA damage response (DDR), comprising checkpoint and repair systems. The DDR suppresses cancer by promoting genome stability, and it regulates tumor resistance to chemo- and radi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb1a10b90dc9d4dc98c2c4038d450cc
https://pubmed.ncbi.nlm.nih.gov/24819595

Novel checkpoint response to genotoxic stress mediated by nucleolin-replication protein a complex formation

Autor: Mariza Daras, James A. Borowiec, Diana D. Dimitrova, Kristine M. Carta, Anjana Saxena, Kyung Kim

Publikováno v: Molecular and cellular biology. 25(6)

Human replication protein A (RPA), the primary single-stranded DNA-binding protein, was previously found to be inhibited after heat shock by complex formation with nucleolin. Here we show that nucleolin-RPA complex formation is stimulated after genot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccf292fa037c837fb1d37badd82af43
https://pubmed.ncbi.nlm.nih.gov/15743838

Composite Hydrogel with Oleic Acid-Grafted Mesoporous Silica Nanoparticles for Enhanced Topical Delivery of Doxorubicin.

Autor: Slavkova M; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Medical University-Sofia, 1000 Sofia, Bulgaria., Dimitrova D; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Medical University-Sofia, 1000 Sofia, Bulgaria., Voycheva C; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Medical University-Sofia, 1000 Sofia, Bulgaria., Popova T; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Medical University-Sofia, 1000 Sofia, Bulgaria., Spassova I; Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria., Kovacheva D; Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria., Yordanov Y; Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University-Sofia, 1000 Sofia, Bulgaria., Tzankova V; Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University-Sofia, 1000 Sofia, Bulgaria., Tzankov B; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Medical University-Sofia, 1000 Sofia, Bulgaria.

Publikováno v: Gels (Basel, Switzerland) [Gels] 2024 May 22; Vol. 10 (6). Date of Electronic Publication: 2024 May 22.

Hypomyelination with Atrophy of Basal Ganglia and Cerebellum (HABC) Due to UFM1 Mutation in Roma Patients - Severe Early Encephalopathy with Stridor and Severe Hearing and Visual Impairment. A Single Center Experience.

Autor: Ivanov I; Department of Pediatrics, Saint George University Hospital, Plovdiv, Bulgaria.; Department of Pediatrics and Medical Genetics, Medical University of Plovdiv, Plovdiv, Bulgaria.; Research Institute, Medical University of Plovdiv, Plovdiv, Bulgaria., Pacheva I; Department of Pediatrics, Saint George University Hospital, Plovdiv, Bulgaria.; Department of Pediatrics and Medical Genetics, Medical University of Plovdiv, Plovdiv, Bulgaria.; Research Institute, Medical University of Plovdiv, Plovdiv, Bulgaria., Yordanova R; Department of Pediatrics, Saint George University Hospital, Plovdiv, Bulgaria.; Department of Pediatrics and Medical Genetics, Medical University of Plovdiv, Plovdiv, Bulgaria.; Research Institute, Medical University of Plovdiv, Plovdiv, Bulgaria., Sotkova I; Department of Pediatrics, Saint George University Hospital, Plovdiv, Bulgaria.; Department of Pediatrics and Medical Genetics, Medical University of Plovdiv, Plovdiv, Bulgaria., Galabova F; Department of Pediatrics, Saint George University Hospital, Plovdiv, Bulgaria., Gaberova K; Department of Pediatrics, Saint George University Hospital, Plovdiv, Bulgaria.; Department of Pediatrics and Medical Genetics, Medical University of Plovdiv, Plovdiv, Bulgaria.; Research Institute, Medical University of Plovdiv, Plovdiv, Bulgaria., Panova M; Department of Pediatrics, Saint George University Hospital, Plovdiv, Bulgaria.; Department of Pediatrics and Medical Genetics, Medical University of Plovdiv, Plovdiv, Bulgaria., Gheneva I; Department of Pediatrics, Saint George University Hospital, Plovdiv, Bulgaria.; Department of Pediatrics and Medical Genetics, Medical University of Plovdiv, Plovdiv, Bulgaria., Tsvetanova T; Department of Pediatrics, Saint George University Hospital, Plovdiv, Bulgaria.; Department of Pediatrics and Medical Genetics, Medical University of Plovdiv, Plovdiv, Bulgaria., Noneva K; Department of Pediatrics, University Hospital 'St. Marina', Medical University of Varna, Varna, Bulgaria., Dimitrova D; Department of Radiology, Saint George University Hospital, Plovdiv, Bulgaria., Markov S; ENT Clinic, Saint George University Hospital, Plovdiv, Bulgaria.; Department of Otorhinolaryngology Medical Faculty, Medical University of Plovdiv, Plovdiv, Bulgaria., Sapundzhiev N; Department of Otorhinolaryngology, University Hospital 'St. Marina', Medical University of Varna, Varna, Bulgaria., Bichev S; National Genetic Laboratory, Maichin Dom University Hospital, Sofia, Bulgaria., Savov A; National Genetic Laboratory, Maichin Dom University Hospital, Sofia, Bulgaria.

Publikováno v: CNS & neurological disorders drug targets [CNS Neurol Disord Drug Targets] 2023; Vol. 22 (2), pp. 207-214.