Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Diana C. Rostirolla"'
Autor:
José Eduardo Sacconi Nunes, Diana C. Rostirolla, Jones Limberger, Diógenes Santiago Santos, Pablo Machado, Juleane Lunardi, Alessandra Silva Raupp, Anne Drumond Villela, Kenia Pissinate, Leonardo K. Martinelli, Osmar Norberto de Souza, Luis Fernando Saraiva Macedo Timmers, Luiz Augusto Basso
Publikováno v:
RSC Advances. 6:28406-28418
HisD-Encoded histidinol dehydrogenase (HisD) catalyzes the two last chemical reactions of the L-histidine biosynthetic pathway, namely the conversion of L-histidinol (L-Hol) to L-histidinaldehyde (L-Hal) and to L-histidine (L-His). The hisD gene prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ca2064771c2f16a452b1ca93b3a1e1e
https://doi.org/10.1039/c6ra03020c
https://doi.org/10.1039/c6ra03020c
Autor:
Diana C. Rostirolla, Luiz Augusto Basso, Cristiano Valim Bizarro, Thiago M. De Assuncao, Diógenes Santiago Santos
Publikováno v:
RSC Adv.. 4:26271-26287
Enzymes from the nucleotide biosynthesis pathway are potential targets for the development of novel anti-mycobacterial agents. Inosine 5′-monophosphate (IMP) dehydrogenase from Mycobacterium tuberculosis (MtIMPDH) catalyzes the oxidation of IMP to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86d3c62b13f2e940bd8bc439ab5ef723
https://doi.org/10.1039/c4ra02142h
https://doi.org/10.1039/c4ra02142h
Autor:
Luiz Augusto Basso, Kenia Pissinate, Dharmarajan Sriram, Perumal Yogeeswari, Diógenes Santiago Santos, Diana C. Rostirolla, Pablo Machado, Priyanka Suryadevara, Laura Miranda Pinheiro
Publikováno v:
Journal of the Brazilian Chemical Society.
Using an orthologue-based design approach, we synthesized and assayed a series of thiazolyl-1H-benzo[d]imidazole derivatives as inhibitors of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (MtIMPDH). From these experiments, a benzo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ced56f82defd7151807275420ee7765
https://doi.org/10.5935/0103-5053.20150104
https://doi.org/10.5935/0103-5053.20150104
Autor:
Cristiano Valim Bizarro, Candida Deves, Luiz Augusto Basso, Leonardo K. Martinelli, Diógenes Santiago Santos, Diana C. Rostirolla
Publikováno v:
Molecular bioSystems. 10(3)
Human Thymidine Phosphorylase (HTP), also known as the platelet-derived endothelial cell growth factor (PD-ECGF) or gliostatin, catalyzes the reversible phosphorolysis of thymidine (dThd) to thymine and 2-deoxy-α-D-ribose-1-phosphate (2dR1P). HTP is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985543dd667a9da3093ff7f1531ecdae
https://pubmed.ncbi.nlm.nih.gov/24407036
https://pubmed.ncbi.nlm.nih.gov/24407036
Autor:
Guilherme Oliveira Petersen, Diógenes Santiago Santos, Ana Paula de Souza, Cristiano Valim Bizarro, Jocelei Maria Chies, Diana C. Rostirolla, Juleane Lunardi, Gaby Renard, Luiz Augusto Basso, José Eduardo Sacconi Nunes, Laura S Marder, Ana Christina de Oliveira Dias
Publikováno v:
Repositório Institucional PUCRS
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
BMC Biotechnology
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
BMC Biotechnology
Background Annexin V, a 35.8 kDa intracellular protein, is a Ca+2- dependent phospholipid binding protein with high affinity to phosphatidylserine (PS), which is a well-known hallmark of apoptosis. Annexin V is a sensitive probe for PS exposure upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db127ab075fb8f64c86c52bc64e00f2c
Autor:
Diógenes Santiago Santos, Luiz Augusto Basso, Ricardo N. dos Santos, Luis Fernando Saraiva Macedo Timmers, Rafael Victorio Carvalho Guido, Leonardo K. Martinelli, Ivani Pauli, Osmar Norberto de Souza, Diana C. Rostirolla, Adriano D. Andricopulo, Rodrigo G. Ducati
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Mycobacterium tuberculosis InhA (MtInhA) is an attractive enzyme to drug discovery efforts due to its validation as an effective biological target for tuberculosis therapy. In this work, two different virtual-ligand-screening approaches were applied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6feff412ea1bfd2a04d849015cb129d
https://pubmed.ncbi.nlm.nih.gov/23889525
https://pubmed.ncbi.nlm.nih.gov/23889525
Autor:
Léia Jaskulski, Leonardo Astolfi Rosado, Diana C. Rostirolla, Luis Fernando Saraiva Macedo Timmers, Diógenes Santiago Santos, Osmar Norberto de Souza, Luiz Augusto Basso
Publikováno v:
Archives of biochemistry and biophysics. 536(1)
Cytidine monophosphate kinase from Mycobacterium tuberculosis (MtCMK) likely plays a role in supplying precursors for nucleic acid synthesis. MtCMK catalyzes the ATP-dependent phosphoryl group transfer preferentially to CMP and dCMP. Initial velocity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8f2aeae3d6e72da66641e27664c186
https://pubmed.ncbi.nlm.nih.gov/23756762
https://pubmed.ncbi.nlm.nih.gov/23756762
Autor:
Leonardo Astolfi Rosado, Diana C. Rostirolla, Diógenes Santiago Santos, Ardala Breda, Luiz Augusto Basso, Mario Sergio Palma
Publikováno v:
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
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Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c84d8503e4276b94deb290ba5fe203