Cofilin dysregulation alters actin turnover in frataxin-deficient neurons

Autor: Diana C. Muñoz-Lasso, Belén Mollá, Pablo Calap-Quintana, José Luis García-Giménez, Federico V. Pallardo, Francesc Palau, Pilar Gonzalez-Cabo

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)

Abstract Abnormalities in actin cytoskeleton have been linked to Friedreich’s ataxia (FRDA), an inherited peripheral neuropathy characterised by an early loss of neurons in dorsal root ganglia (DRG) among other clinical symptoms. Despite all effort

Externí odkaz: https://doaj.org/article/1c2e1b48290849ff8db4190d1f6da79c

Two different pathogenic mechanisms, dying-back axonal neuropathy and pancreatic senescence, are present in the YG8R mouse model of Friedreich’s ataxia

Autor: Belén Mollá, Fátima Riveiro, Arantxa Bolinches-Amorós, Diana C. Muñoz-Lasso, Francesc Palau, Pilar González-Cabo

Publikováno v: Disease Models & Mechanisms, Vol 9, Iss 6, Pp 647-657 (2016)

Frataxin (FXN) deficiency causes Friedreich’s ataxia (FRDA), a multisystem disorder with neurological and non-neurological symptoms. FRDA pathophysiology combines developmental and degenerative processes of dorsal root ganglia (DRG), sensory nerves

Externí odkaz: https://doaj.org/article/e0d820fe447041b4905503918978bc04

Reversible Axonal Dystrophy by Calcium Modulation in Frataxin-Deficient Sensory Neurons of YG8R Mice

Autor: Belén Mollá, Diana C. Muñoz-Lasso, Fátima Riveiro, Arantxa Bolinches-Amorós, Federico V. Pallardó, Angel Fernandez-Vilata, María de la Iglesia-Vaya, Francesc Palau, Pilar Gonzalez-Cabo

Publikováno v: Frontiers in Molecular Neuroscience, Vol 10 (2017)

Friedreich’s ataxia (FRDA) is a peripheral neuropathy involving a loss of proprioceptive sensory neurons. Studies of biopsies from patients suggest that axonal dysfunction precedes the death of proprioceptive neurons in a dying-back process. We obs

Externí odkaz: https://doaj.org/article/3192ccb3674a4addb0e6c70b122d19d0

Much More Than a Scaffold: Cytoskeletal Proteins in Neurological Disorders

Autor: Carlos Romá-Mateo, Pilar Gonzalez-Cabo, Federico V. Pallardó, Diana C. Muñoz-Lasso

Publikováno v: Cells, Vol 9, Iss 2, p 358 (2020)
Cells

Recent observations related to the structure of the cytoskeleton in neurons and novel cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases are changing our view on the function of the cytoskeletal proteins in the n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9505d01f07a2de574e22c4fba9556d2
https://www.mdpi.com/2073-4409/9/2/358

Prehospital control of hemorrhage in trauma patients: a feasible secondary prevention strategy in countries of low and median income

Autor: Michael W. Parra, Carlos A. Ordoñez, Julian Chica, Ramiro Manzano-Nunez, Claudia P. Orlas, Juan José Meléndez, Juan Esteban Ruiz, Diana C. Muñoz, Edison Angamarca, Maria Alejandra Londoño, Camilo Jose Salazar, Alberto García, Juan Pablo Herrera, JJ Serna

Publikováno v: Revista Colombiana de Cirugía, Volume: 33, Issue: 4, Pages: 371-379, Published: DEC 2018
Revista Colombiana de Cirugía, Vol 33, Iss 4 (2019)
Redalyc

Resumen Introducción: La hemorragia no controlada es la principal causa prevenible de muerte en trauma. No hay precedentes locales que estimen el efecto de estrategias de prevención que involucren al público en la atención inicial de las víctima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22f93bad60382d8f2d7a290bcbb4178
http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S2011-75822018000400371&lng=en&tlng=en