Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Diana Bachran"'
Autor:
Begoña López, Javier Díez, Susana Ravassa, Gerd Hasenfuss, Tobias Daniel Trippel, Anna F. Dominiczak, Rolf Wachter, Diana Bachran, Frank T. Edelmann, Arantxa González, Doris Bach, Burkert Pieske, Christian Delles
Publikováno v:
European Journal of Heart Failure. 20:1290-1299
Background: Myocardial fibrosis is characterized by excessive cross‐linking and deposition of collagen type I and is involved in left ventricular stiffening and left ventricular diastolic dysfunction (LVDD). We investigated whether the effect of sp
Autor:
Susana, Ravassa, Tobias, Trippel, Doris, Bach, Diana, Bachran, Arantxa, González, Begoña, López, Rolf, Wachter, Gerd, Hasenfuss, Christian, Delles, Anna F, Dominiczak, Burkert, Pieske, Javier, Díez, Frank, Edelmann
Publikováno v:
European journal of heart failure. 20(9)
Myocardial fibrosis is characterized by excessive cross-linking and deposition of collagen type I and is involved in left ventricular stiffening and left ventricular diastolic dysfunction (LVDD). We investigated whether the effect of spironolactone o
Autor:
Christopher Bachran, Patricia Fasold, Peter M. Deckert, Hendrik Fuchs, Diana Bachran, N. Schellmann, Hossein Panjideh
Publikováno v:
Journal of Immunotherapy. 35:570-578
In adults, endothelial cell division occurs only in wound healing, during menstruation, or in diseases such as wet age-related macular degeneration or development of benign or malignant tissues. Angiogenesis is one of the major requirements to supply
Autor:
Alexander Weng, Katharina Mergel, Mayank Thakur, Diana Bachran, Matthias F. Melzig, Roger Gilabert-Oriol, Stefanie Frech, Hendrik Fuchs
Publikováno v:
Biosensors and Bioelectronics. 35:503-506
This work describes the application of an impedance-based measurement for the real time evaluation of targeted tumor therapies in cell culture (HeLa cells). We used a treatment procedure that is well established in cells and mice. Therein, tumor cell
Autor:
Roger Gilabert-Oriol, Sebastian B. Riese, Matthias F. Melzig, Figen Beceren-Braun, Hendrik Fuchs, Kristina Jenett-Siems, Alexander Weng, Christopher Bachran, Mayank Thakur, Diana Bachran
Publikováno v:
Molecular Oncology. 6:323-332
Tumor-targeting protein toxins are composed of a toxic enzyme coupled to a specific cell binding domain that targets cancer-associated antigens. The anti-tumor treatment by targeted toxins is accompanied by dose-limiting side effects. The future pros
Autor:
Annabelle Bertin, Regina Bleul, Raphael Thiermann, Hendrik Fuchs, Michael Maskos, Diana Bachran
Publikováno v:
Macromolecular Symposia. :134-140
Developing polymersomes for drug delivery purposes requires a deeper understanding of their behavior in physiological environment. We performed the self-assembly and in-situ loading of polybutadiene-block-polyethyleneoxide (PB-b-PEO) polymersomes in
Autor:
Matthias F. Melzig, Christopher Bachran, Alexander Weng, Stefanie Schneider, Hendrik Fuchs, Diana Bachran
Publikováno v:
Molecular Pharmaceutics. 8:2262-2272
The expression of the epidermal growth factor (EGF) receptor is upregulated in many human tumors. We developed the targeted toxin SE, consisting of the plant toxin saporin-3 and human EGF. The cytotoxic effect of SE drastically increases in a synergi
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 999:1-18
The cure of cancer is still a formidable challenge in medical science. Long-known modalities including surgery, chemotherapy and radiotherapy are successful in a number of cases; however, invasive, metastasized and inaccessible tumors still pose an u
Autor:
Diana Bachran, Alexander Weng, Romy Urban, Christopher Bachran, Hendrik Fuchs, Stefanie Schneider, Corinna Hoffmann, Andreas M. Kaufmann, Matthias F. Melzig
Publikováno v:
International Journal of Cancer. 127:1453-1461
Cervical cancer is the second most common cancer in women worldwide. Targeting the epidermal growth factor receptor (EGFR) is a very promising approach since it is overexpressed in about 90% of cervical tumors. Here, we quantified the toxic effect of
Autor:
Diana Bachran, Sebastian B. Riese, N. Schellmann, Christopher Bachran, Hendrik Fuchs, Matthias F. Melzig, Alexander Weng
Publikováno v:
British Journal of Pharmacology. 159:345-352
Background and purpose: Certain saponins synergize with antitumour drugs to enhance their efficacy, but the mechanisms underlying this synergy in vivo are not well studied. Here, we describe the distribution of Saponinum album (Spn) from Gypsophila p