Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Diana B. Schramm"'
Autor:
Annelies Müller, Diana B. Schramm, Jackie Kleynhans, Linda de Gouveia, Susan Meiring, Alban Ramette, Anne von Gottberg, Lucy Jane Hathaway
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Streptococcus pneumoniae causes life-threatening meningitis. Its capsular polysaccharide determines the serotype and influences disease severity but the mechanism is largely unknown. Due to evidence of elevated cytokines levels in the mening
Externí odkaz:
https://doaj.org/article/35c3be3933c84aeabf61e94a6c87c84b
Autor:
Avy Violari, Mark F. Cotton, Louise Kuhn, Diana B. Schramm, Maria Paximadis, Shayne Loubser, Sharon Shalekoff, Bianca Da Costa Dias, Kennedy Otwombe, Afaaf Liberty, James McIntyre, Abdel Babiker, Diana Gibb, Caroline T. Tiemessen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Some perinatally HIV infected children who have received early antiretroviral therapy (ART) show long-term sustained virological control after ART cessation. Here the authors describe a case who, at age 9.5 years, shows normal CD4:CD8 T cell ratios a
Externí odkaz:
https://doaj.org/article/0442ca91087b4ff58b5ff26e9317a03a
Autor:
Louise Kuhn, Gayle G. Sherman, Ashraf Coovadia, Megan Burke, Yanhan Shen, Renate Strehlau, Diana B. Schramm, Sharon Shalekoff, Caroline T. Tiemessen, Stephanie Shiau, Karl-Günter Technau, Elaine J. Abrams, Maria Paximadis, Faeezah Patel
Publikováno v:
Pediatr Infect Dis J
BACKGROUND With expansion of antiretroviral therapy (ART) programs, transmission rates are low but new infant infections still occur. We investigated predictors of pre-ART viral load (VL) and CD4+ T-cell counts and percentages in infants diagnosed wi
Autor:
Maria Paximadis, Gregory Minevich, Robert Winchester, Diana B Schramm, Glenda E Gray, Gayle G Sherman, Ashraf H Coovadia, Louise Kuhn, Caroline T Tiemessen
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16541 (2011)
Numerous studies have suggested a role for natural killer (NK) cells in attenuation of HIV-1 disease progression via recognition by killer-cell immunoglobulin-like receptors (KIRs) of specific HLA class I molecules. The role of KIR and HLA class I ha
Externí odkaz:
https://doaj.org/article/176f224334cc4f4783e62aefb37487b6
Autor:
Karl Technau, Stephanie Shiau, Diana B. Schramm, Elaine J. Abrams, Renate Strehlau, Ashraf Coovadia, Louise Kuhn, Francoise Pinillos, Adrian Puren, Caroline T. Tiemessen
Publikováno v:
AIDS. 29:1053-1060
Negative results on standard HIV antibody tests have been described among HIV-infected children suppressed on antiretroviral therapy (ART) started early in life. Here, we describe the frequency and predictors of this phenomenon in a well characterize
Autor:
Louise Kuhn, Ashraf Coovadia, Busani Mathebula, Glenda Gray, Diana B. Schramm, Caroline T. Tiemessen, Gayle G. Sherman, Fiona Anthony
Publikováno v:
The Open AIDS Journal
Maternal HIV-1 status and antiretroviral drug exposure may influence the haematological profiles of infants. We recruited infants from 118 uninfected control women and from 483 HIV-1 infected women who received no antiretroviral drugs (n=28), or rece
Autor:
Gayle G. Sherman, Stephen Meddows-Taylor, Caroline T. Tiemessen, Maria A. Papathanasopoulos, Diana B. Schramm, Glenda Gray, Sharon Shalekoff, Louise Kuhn, Ashraf Coovadia
Publikováno v:
The Journal of Immunology. 182:5914-5918
Most infants exposed to HIV-1 in utero and at delivery do not acquire infection. We show that mothers and infants who have CD3-negative cells that respond to HIV-1 peptides are substantially less likely to transmit and acquire infection, respectively
Autor:
Louise Kuhn, Gayle G. Sherman, Ashraf Coovadia, Stephen Meddows-Taylor, Diana B. Schramm, Glenda Gray, Samantha L. Donninger, Caroline T. Tiemessen, Sharon Shalekoff
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 48:245-254
HIV-specific T-cell responses play an important role in control of infection. Because CCL3 has immune modulatory and antiviral activities, we hypothesized that host CCL3 genotype (CCL3L1 gene duplications) would influence the development of effective
Publikováno v:
Clinical and Vaccine Immunology. 14:348-354
Human immunodeficiency virus type 1 (HIV-1)-specific cellular immune responses are elicited in a proportion of infants born to HIV-1-infected mothers and are associated with protection against vertical transmission. To investigate correlates of these
Autor:
Caroline T. Tiemessen, Anabela C.P. Picton, Sharon Shalekoff, Ria Lassaunière, Diana B. Schramm
Publikováno v:
Cytokine. 61(3)
The G-protein-coupled receptor, CXCR4, is highly expressed on a number of cell types, and together with its ligand, CXCL12, plays an important role in immune development and trafficking of cells. CXCR4 promotes tumor growth, angiogenesis and metastas