Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Diana A Stavreva"'
Autor:
Benjamin P Flynn, Matthew T Birnie, Yvonne M Kershaw, Audrys G Pauza, Sohyoung Kim, Songjoon Baek, Mark F Rogers, Alex R Paterson, Diana A Stavreva, David Murphy, Gordon L Hager, Stafford L Lightman, Becky L Conway-Campbell
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009737 (2021)
Ultradian glucocorticoid rhythms are highly conserved across mammalian species, however, their functional significance is not yet fully understood. Here we demonstrate that pulsatile corticosterone replacement in adrenalectomised rats induces a dynam
Externí odkaz:
https://doaj.org/article/ebb7253002144d5885d6bce3701f46a0
Autor:
Diana A. Stavreva, Lyuba Varticovski, Razi Raziuddin, Gianluca Pegoraro, R. Louis Schiltz, Gordon L. Hager
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Progesterone receptor (PR)-interacting compounds in the environment are associated with serious health hazards. However, methods for their detection in environmental samples are cumbersome. We report a sensitive activity-based biosensor for
Externí odkaz:
https://doaj.org/article/22d46109ab134ab3baf024db0dc843bd
Autor:
Kaustubh Wagh, Diana A Stavreva, Rikke AM Jensen, Ville Paakinaho, Gregory Fettweis, R Louis Schiltz, Daniel Wüstner, Susanne Mandrup, Diego M Presman, Arpita Upadhyaya, Gordon L Hager
How transcription factors (TFs) navigate the complex nuclear environment to assemble the transcriptional machinery at specific genomic loci remains elusive. Using single-molecule tracking, coupled with machine learning, we examined the mobility of mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eab9acdd97e164006f26bf28f5e66e6a
https://doi.org/10.1101/2022.07.25.501476
https://doi.org/10.1101/2022.07.25.501476
Autor:
Paul M. Bradley, Dana W. Kolpin, Darrin A. Thompson, Kristin M. Romanok, Kelly L. Smalling, Sara E. Breitmeyer, Mary C. Cardon, David M. Cwiertny, Nicola Evans, R. William Field, Michael J. Focazio, Laura E. Beane Freeman, Carrie E. Givens, James L. Gray, Gordon L. Hager, Michelle L. Hladik, Jonathan N. Hofmann, Rena R. Jones, Leslie K. Kanagy, Rachael F. Lane, R. Blaine McCleskey, Danielle Medgyesi, Elizabeth K. Medlock-Kakaley, Shannon M. Meppelink, Michael T. Meyer, Diana A. Stavreva, Mary H. Ward
Publikováno v:
Science of The Total Environment. 868:161672
Autor:
Lorenzo Rinaldi, Gregory Fettweis, Sohyoung Kim, David A. Garcia, Saori Fujiwara, Thomas A. Johnson, Theophilus T. Tettey, Laurent Ozbun, Gianluca Pegoraro, Michele Puglia, Blagoy Blagoev, Arpita Upadhyaya, Diana A. Stavreva, Gordon L. Hager
Publikováno v:
Rinaldi, L, Fettweis, G, Kim, S, Garcia, D A, Fujiwara, S, Johnson, T A, Tettey, T T, Ozbun, L, Pegoraro, G, Puglia, M, Blagoev, B, Upadhyaya, A, Stavreva, D A & Hager, G L 2022, ' The glucocorticoid receptor associates with the cohesin loader NIPBL to promote long-range gene regulation ', Science Advances, vol. 8, no. 13, eabj8360 . https://doi.org/10.1126/sciadv.abj8360
The cohesin complex is central to chromatin looping, but mechanisms by which these long-range chromatin interactions are formed and persist remain unclear. We demonstrate that interactions between a transcription factor (TF) and the cohesin loader NI
Autor:
Eric A. Ortlund, Gordon L. Hager, Kendall W. Nettles, René Houtman, Donald G. Phinney, Tina Izard, Xu Liu, Zhuang Jin, Douglas J. Kojetin, Olivier Elemento, Jerome C. Nwachukwu, Diana A. Stavreva, Sathish Srinivasan, Jason Nowak, Michael D. Cameron, Charles C. Nettles, Nelson E Bruno, Theodore M. Kamenecka, Siddaraju V. Boregowda
Publikováno v:
Nat Chem Biol
Glucocorticoids display remarkable anti-inflammatory activity, but their use is limited by on-target adverse effects including insulin resistance and skeletal muscle atrophy. We used a chemical systems biology approach, ligand class analysis, to exam
Autor:
Matthew T. Birnie, Alex Paterson, Diana A. Stavreva, YM Kershaw, Becky L. Conway-Campbell, Audrys G Pauza, Songjoon Baek, David Murphy, Mark F. Rogers, Benjamin P. Flynn, Sohyoung Kim, Gordon L. Hager, Stafford L. Lightman
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009737 (2021)
Flynn, B P, Birnie, M T, Kershaw, Y M, Pauza, A G, Kim, S, Baek, S, Rogers, M F, Paterson, A R, Stavreva, D A, Murphy, D, Hager, G L, Lightman, S L & Conway-Campbell, B L 2021, ' Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver ', PLoS Genetics, vol. 17, no. 8, e1009737, pp. e1009737 . https://doi.org/10.1371/journal.pgen.1009737
PLoS Genetics
Flynn, B P, Birnie, M T, Kershaw, Y M, Pauza, A G, Kim, S, Baek, S, Rogers, M F, Paterson, A R, Stavreva, D A, Murphy, D, Hager, G L, Lightman, S L & Conway-Campbell, B L 2021, ' Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver ', PLoS Genetics, vol. 17, no. 8, e1009737, pp. e1009737 . https://doi.org/10.1371/journal.pgen.1009737
PLoS Genetics
Ultradian glucocorticoid rhythms are highly conserved across mammalian species, however, their functional significance is not yet fully understood. Here we demonstrate that pulsatile corticosterone replacement in adrenalectomised rats induces a dynam
Publikováno v:
Mol Cell Endocrinol
Sex hormones, such as androgens, estrogens and progestins are naturally occurring compounds that tightly regulate endocrine systems in a variety of living organisms. Uncontrolled environmental exposure to these hormones or their biological and synthe
Autor:
Thomas A. Johnson, David A. Garcia, Diego M. Presman, Ville Paakinaho, Gordon L. Hager, Lorenzo Rinaldi, Kaustubh Wagh, Grégory Fettweis, Susanne Mandrup, Rikke A.M. Jensen, Diana A. Stavreva, Arpita Upadhyaya
Publikováno v:
Garcia, D A, Johnson, T A, Presman, D M, Fettweis, G, Wagh, K, Rinaldi, L, Stavreva, D A, Paakinaho, V, Jensen, R A M, Mandrup, S, Upadhyaya, A & Hager, G L 2021, ' An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors ', Molecular Cell, vol. 81, no. 7, pp. 1484-1498 . https://doi.org/10.1016/j.molcel.2021.01.013
Mol Cell
Mol Cell
Transcription factors (TFs) regulate gene expression by binding to specific consensus motifs within the local chromatin context. The mechanisms by which TFs navigate the nuclear environment as they search for binding sites remain unclear. Here, we us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f161faca86b8e81444c1c50149dedf49
https://portal.findresearcher.sdu.dk/da/publications/fd6e8ddf-9c32-4533-bf0c-0734c797c6cd
https://portal.findresearcher.sdu.dk/da/publications/fd6e8ddf-9c32-4533-bf0c-0734c797c6cd
Autor:
René Houtman, Eric A. Ortlund, Xu Liu, Olivier Elemento, Zhuang Jin, Charles C. Nettles, Jerome C. Nwachukwu, Kendall W. Nettles, Diana A. Stavreva, Sathish Srinivasan, Nelson E Bruno, Gordon L. Hager, Theodore M. Kamenecka, Donald G. Phinney, Tina Izard, Douglas J. Kojetin, Siddaraju V. Boregowda
Glucocorticoids display remarkable anti-inflammatory activity, but their use is limited by on-target adverse effects including insulin resistance and skeletal muscle atrophy. We used a chemical systems biology approach, Ligand Class Analysis (LCA), t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faa6458e62476dbf8e06fab9bb336542
https://doi.org/10.1101/2020.06.15.153270
https://doi.org/10.1101/2020.06.15.153270