Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Diana, Pendin"'
Autor:
Annamaria Lia, Gabriele Sansevero, Angela Chiavegato, Miriana Sbrissa, Diana Pendin, Letizia Mariotti, Tullio Pozzan, Nicoletta Berardi, Giorgio Carmignoto, Cristina Fasolato, Micaela Zonta
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Altered Ca2+ signaling is involved in the pathogenesis of Alzheimer’s disease. Here, the authors show Ca2+ hypoactivity in astrocytes at plaque deposition onset related to reduced expression of the Ca2+ sensor STIM1 and impaired synaptic plasticity
Externí odkaz:
https://doaj.org/article/2692d4385d9d452f9a4c2132e63f0f7d
Autor:
Javier Espadas, Diana Pendin, Rebeca Bocanegra, Artur Escalada, Giulia Misticoni, Tatiana Trevisan, Ariana Velasco del Olmo, Aldo Montagna, Sergio Bova, Borja Ibarra, Peter I. Kuzmin, Pavel V. Bashkirov, Anna V. Shnyrova, Vadim A. Frolov, Andrea Daga
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The endoplasmic reticulum (ER) is an intracellular network characterized by highly dynamic behavior whose control mechanisms are unclear. Here, the authors show that the ER-membrane protein Reticulon (Rtnl1) can constrict ER bilayers and lead to ER f
Externí odkaz:
https://doaj.org/article/10c1788afa3d49929d11bf1b49ae7042
Autor:
Elisa Greotti, Ilaria Fortunati, Diana Pendin, Camilla Ferrante, Luisa Galla, Lorena Zentilin, Mauro Giacca, Nina Kaludercic, Moises Di Sante, Letizia Mariotti, Annamaria Lia, Marta Gómez-Gonzalo, Michele Sessolo, Giorgio Carmignoto, Renato Bozio, Tullio Pozzan
Publikováno v:
iScience, Vol 16, Iss , Pp 340-355 (2019)
Summary: Genetically Encoded Ca2+ Indicators (GECIs) are extensively used to study organelle Ca2+ homeostasis, although some available probes are still plagued by a number of problems, e.g., low fluorescence intensity, partial mistargeting, and pH se
Externí odkaz:
https://doaj.org/article/68a895b0109142569ddc88129249e310
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
The endoplasmic reticulum (ER) is a highly dynamic network whose shape is thought to be actively regulated by membrane resident proteins. Mutation of several such morphology regulators cause the neurological disorder Hereditary Sp astic Paraplegia (H
Externí odkaz:
https://doaj.org/article/b8482dc739fb4e6ea19e6786f990583e
Publikováno v:
Cell Reports, Vol 23, Iss 6, Pp 1742-1753 (2018)
Summary: Mitochondria shape is controlled by membrane fusion and fission mediated by mitofusins, Opa1, and Drp1, whereas mitochondrial motility relies on microtubule motors. These processes govern mitochondria subcellular distribution, whose defects
Externí odkaz:
https://doaj.org/article/7895ab5fec1a401ebd2927f9a0e57277
Publikováno v:
Cells, Vol 10, Iss 11, p 2870 (2021)
The endoplasmic reticulum (ER) is the most abundant and widespread organelle in cells. Its peculiar membrane architecture, formed by an intricate network of tubules and cisternae, is critical to its multifaceted function. Regulation of ER morphology
Externí odkaz:
https://doaj.org/article/8fd07e3868d443a29590540751b68264
Publikováno v:
Cells, Vol 10, Iss 8, p 2133 (2021)
Calcium (Ca2+) signaling coordinates are crucial processes in brain physiology. Particularly, fundamental aspects of neuronal function such as synaptic transmission and neuronal plasticity are regulated by Ca2+, and neuronal survival itself relies on
Externí odkaz:
https://doaj.org/article/68d9e4f4e47d464cbfcc5b3c9cd1858f
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
The endoplasmic reticulum (ER) extends as a network of interconnected tubules and sheet-like structures in eukaryotic cells. ER tubules dynamically change their morphology and position within the cells in response to physiological stimuli and these n
Externí odkaz:
https://doaj.org/article/24159bd9fed94ceb9fe0d1c16a9d08c9
Autor:
Paola Pizzo, Emy Basso, Riccardo Filadi, Elisa Greotti, Alessandro Leparulo, Diana Pendin, Nelly Redolfi, Michela Rossini, Nicola Vajente, Tullio Pozzan, Cristina Fasolato
Publikováno v:
Cells, Vol 9, Iss 10, p 2166 (2020)
Presenilin-2 (PS2) is one of the three proteins that are dominantly mutated in familial Alzheimer’s disease (FAD). It forms the catalytic core of the γ-secretase complex—a function shared with its homolog presenilin-1 (PS1)—the enzyme ultimate
Externí odkaz:
https://doaj.org/article/77b7dcffd7784e8b81cd1a266393c925
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
Mitochondria are dynamic organelles whose morphology and activity are extremely variable, depending on the metabolic state of the cell. In particular, their shape and movements within the cell are finely regulated by an increasing number of proteins,
Externí odkaz:
https://doaj.org/article/c2a28675424c4fc9b5c6ff39b95cf4aa