Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis

Autor: Diana Caridha, Brian Vesely, Katrien van Bocxlaer, Byron Arana, Charles E. Mowbray, Sima Rafati, Silvia Uliana, Rosa Reguera, Mara Kreishman-Deitrick, Richard Sciotti, Pierre Buffet, Simon L. Croft

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 11, Iss , Pp 106-117 (2019)

Although there have been significant advances in the treatment of visceral leishmaniasis (VL) and several novel compounds are currently in pre-clinical and clinical development for this manifestation of leishmaniasis, there have been limited advances

Externí odkaz: https://doaj.org/article/e8feae56d3084dfcba7c0b0f20b1a9bd

Updating the modified Thompson test by using whole-body bioluminescence imaging to replace traditional efficacy testing in experimental models of murine malaria

Autor: Diana Caridha, Mark Hickman, Lisa Xie, Franklyn Ngundam, Erin Milner, Amanda Schenk, Kirk Butler, Dylan Nugent, Patricia Lee, Norma Roncal, Susan Leed, Eve Hosford, Jangwoo Lee, Richard J. Sciotti, Gregory Reichard, Chad Black, Mara Kreishman-Deitrick, Qigui Li, Brian Vesely

Publikováno v: Malaria Journal, Vol 18, Iss 1, Pp 1-15 (2019)

Abstract Background Rodent malaria models are extensively used to predict treatment outcomes in human infections. There is a constant need to improve and refine these models by innovating ways to apply new scientific findings and cutting edge technol

Externí odkaz: https://doaj.org/article/b2caeece80d94ce2ab66bc1e98c7f17b

Combination of Subtherapeutic Doses of Tretazicar and Liposomal Amphotericin B Suppresses and Cures Leishmania major-Induced Cutaneous Lesions in Murine Models

Autor: Mara Kreishman-Deitrick, Richard J. Sciotti, Brian Vesely, Jason C. Sousa, Elizabeth R. Sharlow, Patricia J. Lee, Tesfaye Teshome, John S. Lazo, Mozna Khraiwesh, Erica Penn, Brandon S. Pybus, Chau Vuong, Susan E. Leed, Diana Caridha, Gustave Bonkoungou

Publikováno v: ACS Infectious Diseases. 7:506-517

Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis affecting human populations, yet CL remains largely ignored in drug discovery programs. CL causes disfiguring skin lesions and often relapses after "clinical cure" using existing t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27d57831295a01ada44f84b2b146bb61
https://doi.org/10.1021/acsinfecdis.0c00886

Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases

Autor: Glen Spraggon, Smith Jeffrey M, Chianelli Donatella, Advait Nagle, Christian Wiesmann, Xiaodong Liu, Yongping Xie, Richard J. Sciotti, Todd Groessl, Kevin Johnson, Xianzhong Liu, Celine Be, Christopher Thompson, Yin H. Lai, Jan Jiricek, Patrick J Rudewicz, Brandon S. Pybus, Casey J. N. Mathison, Valentina Molteni, Honnappa Srinivas, Richard Glynne, Jaime Ballard, Agnes Biggart, Diana Caridha, Andreas Hein, Ashley Mitchell Berman, Mu-Yun Gao, Lauren C. Davis, Michael Shapiro, Michael Gibney, Yen Liang Chen, Vince Yeh, Fabian K. Eggimann, Badry Bursulaya, Mara Kreishman-Deitrick, Lerario Isabelle K, Fang Liang, Shilpi Khare, Wendy Richmond, Srinivasa P. S. Rao, Frantisek Supek, Tove Tuntland, Alexandre Luneau

Publikováno v: Journal of Medicinal Chemistry

Visceral leishmaniasis is responsible for up to 30,000 deaths every year. Current treatments have shortcomings that include toxicity and variable efficacy across endemic regions. Previously, we reported the discovery of GNF6702, a selective inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37584f6654d3dc34b0710ef1ed444634
https://doi.org/10.1021/acs.jmedchem.0c00499

Novel benzoxaborole, nitroimidazole and aminopyrazoles with activity against experimental cutaneous leishmaniasis

Autor: Gert-Jan Wijnant, Charles E. Mowbray, Diana Caridha, Katrien Van Bocxlaer, Simon L. Croft, Richard J. Sciotti, Brian Vesely, Vanessa Yardley, Jean-Robert Ioset, Chad C. Black, Susan E. Leed, Stéphanie Braillard

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 11, Iss, Pp 129-138 (2019)
International Journal for Parasitology: Drugs and Drug Resistance

Objectives Drugs for Neglected Diseases initiative (DNDi) has identified three chemical lead series, the nitroimidazoles, benzoxaboroles and aminopyrazoles, as innovative treatments for visceral leishmaniasis. The leads discovered using phenotypic sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dfdf3e2478376cfadde6d14cd3d0e8b
http://www.sciencedirect.com/science/article/pii/S2211320718301854