Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Dian Xiao"'
Publikováno v:
Journal of Rock Mechanics and Geotechnical Engineering, Vol 16, Iss 7, Pp 2503-2515 (2024)
A growing rock engineering activity in cold regions is facing the threat of freeze-thaw (FT) weathering, especially in high mountains where the sunny-shady slope effects strongly control the difference in weathering behavior of rocks. In this paper,
Externí odkaz:
https://doaj.org/article/816ee4fdb0fb4338af48da8323eee486
Publikováno v:
Frontiers in Earth Science, Vol 12 (2024)
In the red-bed areas of southwestern China, subgrade uplift deformation poses a serious safety concern for high-speed trains. However, the subgrade uplift mechanisms are still not well-defined, and there is a lack of effective prediction methods for
Externí odkaz:
https://doaj.org/article/0a1b96a9901b466d8b63b0aa43e004e0
Publikováno v:
Drug Delivery, Vol 30, Iss 1 (2023)
AbstractAiming to address the insufficient endocytosis ability of traditional albumin drug conjugates, this paper reports elegant guanidine modification to improve efficacy for the first time. A series of modified albumin drug conjugates were designe
Externí odkaz:
https://doaj.org/article/0349dbb13e0a4bb4bd9747964596d3b2
Autor:
Mingxiao Yin, Jingwen Dong, Cuicui Sun, Xiaojia Liu, Zhirui Liu, Lu Liu, Zean Kuang, Na Zhang, Dian Xiao, Xinbo Zhou, Hongbin Deng
Publikováno v:
Advanced Science, Vol 10, Iss 13, Pp n/a-n/a (2023)
Abstract Immune checkpoint therapies (ICT) have achieved unprecedented efficacy in multiple cancer treatments, but are still limited by low clinical response rates. Identification of immunogenic cell death (ICD)‐inducing drugs that can induce tumor
Externí odkaz:
https://doaj.org/article/d42b462d1f7648eb8c2ea06bdd7bf67c
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3889-3907 (2021)
Antibody–drug conjugates (ADCs) are gradually revolutionizing clinical cancer therapy. The antibody–drug conjugate linker molecule determines both the efficacy and the adverse effects, and so has a major influence on the fate of ADCs. An ideal li
Externí odkaz:
https://doaj.org/article/c63ef4542405418fa2fd2886b82340e4
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/2f72519d89e24c8abc8700b938505623
Autor:
Lianqi Liu, Fei Xie, Dian Xiao, Xin Xu, Zheng Su, Yanming Wang, Shiyong Fan, Xinbo Zhou, Song Li
Publikováno v:
Drug Delivery, Vol 28, Iss 1, Pp 2603-2617 (2021)
Camptothecins, traditional chemotherapy drugs, have been clinically used in antibody-drug conjugates (ADCs), which refreshes the recognition that ADCs preferably incorporate highly potent payloads. However, SN-38, active metabolite of irinotecan from
Externí odkaz:
https://doaj.org/article/734e26563ba54e77b224f0fa0e7f421c
Publikováno v:
Frontiers in Environmental Science, Vol 9 (2021)
Phreatic groundwater plays a significant role in the water supply for human communities, especially in water scarce regions. This research was conducted to investigate the hydrochemistry and contamination of phreatic groundwater and their constraints
Externí odkaz:
https://doaj.org/article/c623fd679d944d099b7cc5ce8d56a499
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Analgesics and sedative hypnotics in clinical use often give rise to significant side effects, particularly respiratory depression. For emergency use, specific antagonists are currently administered to counteract respiratory depression. However, anta
Externí odkaz:
https://doaj.org/article/7a75f344444545f4b90ab49215d2992f
Publikováno v:
Cancers, Vol 12, Iss 3, p 744 (2020)
Monomethyl auristatin E (MMAE) is the most popular and widely used cytotoxin in the development of antibody-drug conjugates (ADCs). However, current MMAE-based ADCs are all constructed using cleavable linkers, and this design concept still has insurm
Externí odkaz:
https://doaj.org/article/7374f5d3d4084c8cbd4602030859a5b5