Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Dian Shi Wang"'
Autor:
Anthony Ariza, Setareh Malekian Naeini, Shahin Khodaei, Joycelyn Ba, Dian-Shi Wang, Beverley Anne Orser
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102450- (2023)
Summary: Here, we present a protocol for studying the cell-surface proteins in hippocampal slices after in vivo administration of sevoflurane, an inhaled general anesthetic drug, to mice. We describe steps for anesthetic delivery, hippocampal slice p
Externí odkaz:
https://doaj.org/article/abafcbdd1b5f4ba68eaeff08fcf1596c
Publikováno v:
BJA Open, Vol 6, Iss , Pp 100143- (2023)
Background: Inflammation and general anaesthesia likely contribute to perioperative neurocognitive disorders, possibly by causing a neuronal imbalance of excitation and inhibition. We showed previously that treatment with lipopolysaccharide (LPS) and
Externí odkaz:
https://doaj.org/article/89029342bed244378703f2ae61ccb5b7
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2022)
Background: Perioperative neurocognitive disorders (PNDs) occur commonly in older patients after anesthesia and surgery. Treating astrocytes with general anesthetic drugs stimulates the release of soluble factors that increase the cell-surface expres
Externí odkaz:
https://doaj.org/article/dc2734e62154459bb4a697529fb65d44
Autor:
Jieying Yu, Dian-Shi Wang, Robert P. Bonin, Antonello Penna, Ali Alavian-Ghavanini, Agnieszka A. Zurek, Gail Rauw, Glen B. Baker, Beverley A. Orser
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 203-213 (2019)
Background: Gabapentin is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). Its anticonvulsant, analgesic and anxiolytic properties suggest that it increases GABAergic inhibition; however, the molecular basis for the
Externí odkaz:
https://doaj.org/article/43c28ecae67b4c3abf95fe5bc1cb2ced
Autor:
Ling Yi Guo, Lilia Kaustov, Connor T.A. Brenna, Vikas Patel, Cheng Zhang, Stephen Choi, Stephen Halpern, Dian-Shi Wang, Beverley A. Orser
Publikováno v:
British Journal of Anaesthesia. 130:e351-e360
It remains controversial whether general anaesthetic drugs contribute to perioperative neurocognitive disorders in adult patients. Preclinical studies have generated conflicting results, likely because of differing animal models, study protocols, and
Publikováno v:
British Journal of Anaesthesia. 130:e7-e10
Publikováno v:
EBioMedicine, Vol 55, Iss , Pp - (2020)
Externí odkaz:
https://doaj.org/article/147663b097eb4cd89e50fd99601308e2
Autor:
Beverley A. Orser, Gang Lei, Paul D. Whissell, Michael Dewar, Irene Lecker, Dian-Shi Wang, Andrew J Baker, Heping Sheng, Alejandro Fernandez-Escobar, Nathan K. Chan, Sinziana Avramescu, Shahin Khodaei
Publikováno v:
Critical Care Medicine. 48:533-544
OBJECTIVES Cognitive deficits after traumatic brain injury are a leading cause of disability worldwide, yet no effective pharmacologic treatments exist to improve cognition. Traumatic brain injury increases proinflammatory cytokines, which trigger ex
Autor:
Dian-Shi Wang, Agnieszka A. Zurek, Irene Lecker, Jieying Yu, Armen M. Abramian, Sinziana Avramescu, Paul A. Davies, Stephen J. Moss, Wei-Yang Lu, Beverley A. Orser
Publikováno v:
Cell Reports, Vol 2, Iss 3, Pp 488-496 (2012)
Systemic inflammation causes learning and memory deficits through mechanisms that remain poorly understood. Here, we studied the pathogenesis of memory loss associated with inflammation and found that we could reverse memory deficits by pharmacologic
Externí odkaz:
https://doaj.org/article/1ebcc842bc7d408ba3898da64e571c56
Publikováno v:
Frontiers in Aging Neuroscience
Background: Perioperative neurocognitive disorders (PNDs) occur commonly in older patients after anesthesia and surgery. Treating astrocytes with general anesthetic drugs stimulates the release of soluble factors that increase the cell-surface expres